The choice of optimal antithrombotic therapy for patients undergoing percutaneous coronary interventions (PCI) with an indication for long-term oral anticoagulation (OAT) is challenging. Atrial fibrillation (AF) is one of most frequent indication for OAT, its prevalence is likely to increase in next decades with aging of world population [1]. Recent data showed an increased prevalence of cardiovascular morbidity among patients with AF [2]. Approximately 5–8% of patients treated with PCI have a concomitant atrial fibrillation (AF) [3,4].