On March 23, 2020, the Bergamo hospital team, one of the most challenged teams fighting against COVID-19 web-broadcasted a 1-hour conference on the state of their experience, seeking for discussion and suggestions (https://memorialhermann.zoom.us/j/9270060244). The attendance was about 250 contacts, with many questions raised during the conference. The presentation was very instructive and brain storming. After the conference, and based on current evidence, we developed the hypothesis that the general management of the infection of SARS-CoV-2 should be revised.