Since the beginning of the SARS-CoV-2 pandemic earthquake (more than 1.8 million infected subjects worldwide as of mid-April), differences across countries with regard to hospitalization and death rate are currently emerging, and a series of hypotheses reporting to dissimilarities according to clinical features of patients have been carried out. Given that smoking habit prevalence actually differs according to countries exposed to infection, we explored the prevalence of smoking among hospitalized individuals affected by Coronavirus Disease 2019 (COVID-19).