Sepsis is defined as a dysregulated host response to several types of infections [1], still representing a challenging issue in Medicine. Atrial Fibrillation (AF) frequently occurs in patients with sepsis and septic shock [2], representing one difficult challenge for treating physicians: increased heart rate and loss of atrial kick worsen myocardial function and cardiac output [3]. Unsurprisingly, AF has been consistently associated with worse outcomes in sepsis patients [3].