July 2025

117 Articles

No Section

Refining the predictive value of nasal pressure swing in acute hypoxemic respiratory failure management. Author's reply

24 May 2025
Author(s): Roberto Tonelli, Riccardo Fantini, Luca Tabbì, Ivana Castaniere, Alessandro Marchioni, Enrico Clini

Dear Editor,

Diagnostic contribution of minor salivary glands biopsy in clinical practice

16 May 2025
Author(s): Marion Mauclin, Anh-Tuan Nguyen, Hubert Nielly, Hélène Vanquaethem, Weniko Caré

Dear Editor,

The role of achieving blood pressure targets in renal protection: Insights from the VALUE trial

12 April 2025
Author(s): Yong Wang, Mingzhu Jiang, Wei Zhou

We have read with great interest the article by Olsen et al. on the VALUE trial [1], which investigated the comparative effectiveness of valsartan versus amlodipine in reducing the incidence of end-... more

Demographic features in patients with acute mountain sickness

28 March 2025
Author(s): Haitong Zhao, Hao Wang, Chao Wang, Lei Chen, Fengming Luo

Dear editor,

The Declaration of Helsinki protects clinical trial participants

9 March 2025
Author(s): Rafael Dal-Ré, Søren Holm

Dear Editor,

Some comments on Tecovirimat and mpox

1 March 2025
Author(s): Salvatore Chirumbolo, Umberto Tirelli

The paper by Rizk et al., "Tecovirimat and mpox: A regulatory balancing act between hope, hurdles, and high-risk populations," presents a detailed discussion on the antiviral Tecovirimat (TPOXX) and... more

Commentary

Vitamin D supplements for prevention of diseases

28 June 2025
Author(s): Paul Lips, Renate T de Jongh, Natasja M van Schoor

Vitamin D supplementation is still a cause of considerable controversy. The recent articles of Cimminiello [1], Grant [2] and Cimminiello [3] on the effect of vitamin D supplementation on... more

Community-acquired pneumonia: The burden echoes well beyond discharge

23 June 2025
Author(s): Andrei M. Darie, Daiana Stolz

There is an immense burden associated with pneumonia worldwide. The global incidence of lower respiratory tract infections (LRTI) is estimated to be well over 340 million cases annually with >2... more

Challenges in the diagnosis of coeliac disease in primary care: Serology, biopsy, and administrative data

31 May 2025
Author(s): Marco Vincenzo Lenti, Giovanni Santacroce, Antonio Di Sabatino

Coeliac disease (CD) is a common, lifelong, immune-mediated condition characterised by villous atrophy resulting from the ingestion of dietary gluten [1], which leads to malabsorption and various... more

Intermediate care units in internal medicine – From concept to consolidation

21 May 2025
Author(s): Fredrik von Wowern, George N Dalekos, Ricardo Gómez-Huelgas

The traditional organization of hospital care along rigid specialty lines is increasingly challenged by the complex clinical profiles of today’s inpatients. Multimorbidity, polypharmacy and... more

Predicting the unpredictable: Personalizing VTE risk in cancer with the Caravaggio Score

21 May 2025
Author(s): Elena Butera, Roberto Pola, Marc Carrier

Patients with cancer account for >20 % of all patients newly diagnosed with venous thromboembolism (VTE), which remains a leading cause of morbidity and mortality in this patient population [1].... more

The oldest old and critical care: a potentially successful binomial

20 May 2025
Author(s): Raffaele Antonelli Incalzi, Claudio Pedone

Very old people are frequently denied advanced care on the assumption that they will not benefit from such interventions, even in absence of coexisting conditions that may impact their prognosis [1... more

Editorial

Phenomena and noumena in nephrology: Beyond the illusion of precision in kidney function assessment

3 June 2025
Author(s): Diego Moriconi

In his Critique of Pure Reason, Immanuel Kant famously distinguished between phenomena, the world as it appears to us, and noumena, the thing-in-itself, which eludes direct human comprehension.... more

Ideas and Opinions

Fast versus slow fibrosers: Risk factors for fibrosis progression in eosinophilic oesophagitis

8 May 2025
Author(s): Giovanni Santacroce, Antonio Di Sabatino

Oesophageal fibrosis is a progressive and severe complication of long-standing, T-helper type 2-driven, allergen-mediated inflammation in untreated patients with eosinophilic oesophagitis (EoE) [1].... more

Internal Medicine Flashcard

Progressive skin thickening in a young adult

18 June 2025
Author(s): Thomas Didier, Sophie Leducq, Boris Laure

A 22-year-old man was referred to the dermatology service for the appearance of thickening of the skin, predominantly on the hands, feet and face, accentuation of the folds of the forehead and... more

Inverted V sign

9 June 2025
Author(s): Satoshi Hayano, Yuki Toyama, Masayuki Kashima

A 79-year-old woman visited with a 3-week history of tingling sensation of the tongue. Physical examination showed smooth back ground of tongue with scattered reddish lesions (Fig. 1A). Results of... more

Atypical and fatal presentation of acute liver failure

2 June 2025
Author(s): Ana Pérez González, Javier Martín López, Jesus Rivera-Esteban

A 44-year-old female presented to the emergency department with fever (38 °C) and general malaise three days after an elective hysterectomy for bleeding uterine fibroids. The procedure was... more

Electrocardiographic changes associated with hypothermia

30 May 2025
Author(s): Koji Takahashi, Shigeki Uemura, Katsuji Inoue

A 69-year-old Japanese man, who lived alone and was undergoing treatment for diabetes at another hospital was found unconscious in an unheated room at his residence in February 2025. He was... more

Black discoloration of the esophageal mucosa

22 April 2025
Author(s): Junichi Murakami, Hiroyuki Ariga, Kazuya Nagasaki

A 66-year-old man with type 2 diabetes mellitus and chronic alcohol consumption presented to an acute care hospital with generalized fatigue, anorexia, and melena. On arrival, he was in hypovolemic... more

A protrusion of the left abdominal wall

21 April 2025
Author(s): Li Chai, Ze-Hu Liu

A 73-year-old male presented to the dermatology department following a 5-day history of vesicular rash accompanied with serious pain in the left waist and abdomen. Constipation-associated symptom... more

A man with chronic progressive mucositis and extensive skin detachment

18 April 2025
Author(s): Shohei Kitayama, Teruhiko Makino, Tadamichi Shimizu

A 62-year-old man was referred to our department with a 6-week history of a progressively worsening rash. Three weeks earlier, he had been admitted for gastric perforation, which was ultimately... more

Omalizumab-associated purpura fulminans

17 April 2025
Author(s): Lan Li, Jie Chen, Kun Yang

A 27-year-old male with chronic urticaria began omalizumab treatment. Before treatment, blood count, coagulation profile, and liver function were normal. After one dose, he developed chest, back, and... more

Letter to the Editor

Extended anticoagulation therapy on clinical outcomes in patients with gastrointestinal cancer and isolated distal deep vein thrombosis: Insights from the ONCO DVT Study

30 June 2025
Author(s): Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Koh Ono, Takeshi Kimura, ONCO DVT Study Investigators

The current guidelines have recommended prolonged anticoagulation therapy with direct oral anticoagulants (DOACs) as a potential treatment option for patients with cancer-associated venous... more

Cancer treatment-associated hypomagnesemia: Analysis from a large pharmacovigilance database

30 June 2025
Author(s): Nattawat Klomjit, Richard Evans, Meghan E. Sise, Kenar D. Jhaveri, Shruti Gupta, on behalf of the Hypomagnesemia in Cancer Treatment Working Group

Hypomagnesemia is common among patients with cancer, and can lead to increased morbidity and mortality as well as discontinuation of potentially life-saving treatments. Hypomagnesemia may occur due... more

Are ACE2 rs2285666 and TMPRSS2 rs12329760 polymorphisms a risk factor for the development of Post-COVID-19 condition?

28 June 2025
Author(s): César Fernández-de-las-Peñas, Lars Arendt-Nielsen, Antonio Gil-Crujera, Stella M. Gómez-Sánchez, Gema Díaz-Gil

Evidence on viral mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent causing the coronavirus disease, 2019 (COVID-19), suggests the involvement of several receptors... more

Efficacy and safety of beta-blockers in patients with comorbid chronic obstructive pulmonary disease and cardiovascular disease

20 June 2025
Author(s): Tejuss Kakarla, Yash Vardhan Trivedi, Parth Munjal, Avi Kumar, Rohit Jain

To the editor: Chronic Obstructive Pulmonary Disease (COPD) and cardiovascular disease (CVD) often co-occur, presenting complex management challenges due to concerns over the effects of beta-blockers... more

Addressing unmet needs in the use of SGLT2 inhibitors in critical and acute care setting

16 June 2025
Author(s): Damiano D’Ardes, Fabrizio Ricci, Paola Simeone, Andrea Boccatonda, Francesca Santilli

Despite mounting evidence of benefit in acute heart failure (AHF), acute myocardial infarction (AMI), arrhythmias, and even intensive care settings, there remains a significant lack of clear guidance... more

Role of 12-lead electrocardiogram for identifying very low mortality risk patients with non-hypotensive acute pulmonary embolism

7 June 2025
Author(s): Crhistian-Mario Oblitas, Francisco Galeano-Valle, Luis-Antonio Alvarez-Sala Walther, Pablo Demelo-Rodríguez

Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality and a significant global health issue [1]. The simplified Pulmonary Embolism Severity Index (sPESI) is a practical tool... more

Real-world glucose-lowering strategies for managing glucocorticoid-induced diabetes in non-intensive hospital settings

5 June 2025
Author(s): Michela Vergani, Matteo Conti, Alessia Lari, Federico Bertuzzi, Basilio Pintaudi

A prolonged administration of glucocorticoids (GCs) can lead to side effects such as glucocorticoid-induced diabetes (GC-DM), a form of secondary diabetes, namely drug- or chemical-induced diabetes [... more

Gastroenteritis caused by Shiga-toxigenic Escherichia coli. Are antibiotics always prohibited in this disease?

4 June 2025
Author(s): Juan Gabriel Sánchez-Cano, Ana Belén Mecina-Gutiérrez, Carolina Campelo-Gutiérrez, María Velasco-Arribas, Leonor Moreno-Núñez

Dear Editor-in-Chief and editorial team,

Validation of different acute kidney injury scores in patients undergoing transcatheter aortic valve implantation

29 May 2025
Author(s): Andrea Milzi, Antonio Landi, Daniel Sürder, Giovanni Pedrazzini, Marco Valgimigli

Contrast-associated acute kidney injury (CA-AKI) remains one of the most relevant procedural complications in patients undergoing transcatheter aortic valve implantation (TAVI). Beyond contrast dye... more

Drug-induced hyponatremia in clinical care

28 May 2025
Author(s): Chaker Ben Salem, Dhouha Sahnoun

In their excellent literature review, Mannheimer B et al. do not include several drugs that may induce hyponatremia [1]. Various dopaminergic agents are associated with hyponatremia.

Unmasking atrial cardiomyopathy in middle-aged patients with AF: A call for early detection

27 May 2025
Author(s): A. Borizanova, E. Kinova, A. Goudev

Atrial cardiomyopathy (AtCM) has emerged as a critical clinical entity in recent years, encompassing structural, architectural, electrical, and functional abnormalities in the atria [1]. Atrial... more

Nonarteritic anterior ischemic optic neuropathy and glucagon-like peptide-1 receptor agonists: Evaluating a potential association

21 May 2025
Author(s): Laşin Özbek, Mustafa Güldan, Derya G. Fidan, Sama Mahmoud Abdel-Rahman, Mehmet Kanbay

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for type 2 diabetes mellitus (T2DM) and obesity due to their efficacy in glycemic control, weight reduction, and... more

The role of the hospitalist in Europe: results by EFIM multimorbidity working group survey

21 May 2025
Author(s): Ombretta Para, Flora Kisuule, Arántzazu Álvarez-de Arcaya, Antonio Gonzalez Fernandez, Maximo Bernabeu-Wittel

The increasing prevalence of chronic diseases has led to a population with a higher level of care complexity. Multimorbidity (MM) has emerged as the most prevalent patient profile in both outpatient... more

Insights from the VALUE Trial: Achieving blood pressure targets for renal protection

15 May 2025
Author(s): Eirik Olsen, Camilla L. Søraas, Julian E. Mariampillai, Sverre E. Kjeldsen, Anne C.K. Larstorp, Morten Rostrup

We thank Wang, Jiang and Zhou [1] for their interest in our paper [2]. We agree in their conclusions that the VALUE Trial [2,3] provides critical evidence to guide antihypertensive therapy in high-... more

Hyponatremia and mortality: Marker of disease or modifiable risk? Rethinking causality in large-scale observational research. Authors’ reply

13 May 2025
Author(s): Buster Mannheimer, Jonatan D. Lindh, Issa Issa, Henrik Falhammar, Jakob Skov

We would like to thank Xia et al. for their thorough evaluation of our recent work based on the Stockholm Sodium Cohort (SSC) [1,2], in which they raise several concerns, some of which are inherent... more

Genotype-phenotype correlations and resistance to colchicine in a familial Mediterranean fever cohort in southwestern Spain

13 May 2025
Author(s): Carlos Hernández Quiles, Ana Casado Díaz, Aurora González Estrada, Marco Antonio Montes Cano, José Salvador García Morillo

Familial Mediterranean Fever (FMF) is the most frequent autoinflammatory disease, characterized by recurrent episodes of fever, abdominal pain, arthritis, and rash. It primarily affects people in the... more

Abrupt fluoroquinolone-associated suicides: a SONAR report from North America, Europe, Australia, and Asia

13 May 2025
Author(s): Charles L. Bennett, Mia Lynch, Gretchen LeFever Watson, Linda Martin, June M. McKoy, for the Southern Network and Advserse Reactions

One billion doses of fluoroquinolone (FQ) antibiotics have been administered since 1987. In 1998, the German Pharmaceutical Regulatory Agency received “a few” suicide reports that occurred shortly... more

Disabling hearing loss in ischemic stroke: Prevalence, predictors, and prognostic implications

30 April 2025
Author(s): Angeline Yi Ling Teo, Hazel Kai Hui Yeo, Amy May Lin Quek, Jenny Hooi Yin Loo, Raymond Chee Seong Seet, Hearing in Stroke Study Group

Growing evidence suggests that hearing loss may be an overlooked risk factor and consequence of ischemic stroke [1]. Several large-scale cohort analyses indicate that individuals with hearing loss... more

Serum IL-18 in autoinflammatory diseases diagnosis: unresolved challenges

28 April 2025
Author(s): Hongxin Shu, Mingyu Liang

We read with great the article by Elhani et al. recently published in the European Journal of Internal Medicine [1]. This study attempts to establish the relationship between interleukin-18 (IL-18)... more

Hyponatremia and mortality: Marker of disease or modifiable risk? Rethinking causality in large-scale observational research

25 April 2025
Author(s): Xin Xia, Tao Zhang, Kai Zhao, Kun Huang

We read with great interest the article by Mannheimer et al. investigating mortality and causes of death in patients hospitalized with hyponatremia using a large propensity-matched cohort from the... more

Prognostic impact of bone scintigraphy in elderly patients with hypertrophic cardiomyopathy

21 April 2025
Author(s): Younes Kamal, Lisa Lochon, Anne Bernard, Arnaud Bisson, Laurent Fauchier

Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition that may result from sarcomeric mutations or infiltrative disorders such as transthyretin amyloid cardiomyopathy (ATTR-CM) [1].... more

Prevalence, awareness, and control of cardiovascular risk factors among specialists in cardiovascular field: A survey

19 April 2025
Author(s): Claudia Agabiti Rosei, Rita Del Pinto, Maria Lorenza Muiesan, Claudio Ferri, Guido Grassi, PROTECTO study group

Dear Editor,

Short term variability of peripheral blood eosinophil count in individuals with stable COPD

16 April 2025
Author(s): Claudio Candia, Claudia Merola, Salvatore Fuschillo, Pasquale Ambrosino, Nicolino Ambrosino, Mauro Maniscalco

Chronic obstructive pulmonary disease (COPD) is typically considered a neutrophil-driven inflammatory disease [1], but some individuals, particularly those with frequent exacerbations, show... more

Trends in cardiovascular disease-related mortality among adults with sleep apnea in the United States from 1999-2020

15 April 2025
Author(s): Usama Qamar, Siddharth Agarwal, Maaz Asif, Waleed Qamar, Zain Ul Abideen Asad

Cardiovascular disease-related mortality in adults with comorbid sleep apnea in the United States from 1999 to 2020.

Cardiovascular safety and efficacy of intensive blood pressure control: how low should we go?

14 April 2025
Author(s): Paschalis Karakasis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis, Ricardo Gómez-Huelgas

Dear Editor,

Excess risk or misestimated baseline? Reconsidering relative survival in the oldest ICU patients

11 April 2025
Author(s): Juan Ye, Kun Huang

We commend Weller et al. for their important and timely contribution, which provides a rigorous and impressively sized analysis of 1076 ICU patients aged 90 years and older, using relative survival... more

Clinical epidemiological characteristics of BRASH syndrome

5 April 2025
Author(s): Junji Kaneyama, Yoshihito Goto, Maki Murata, Tadanobu Irie, Takashi Kawamura

BRASH syndrome—characterized by bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia—has recently been recognized as a distinct clinical entity. This syndrome is... more

Protected discharge and combined interventions: A viable path to reduce hospital readmissions

2 April 2025
Author(s): Gianluca Azzellino, Ernesto Aitella, Mauro Passamonti, Lia Ginaldi, Massimo De Martinis

Hospital readmissions within 30 days continue to be a challenge for healthcare systems, particularly in the case of frail, elderly patients and those with chronic diseases. From international studies... more

Clinical trial landscape for pulmonary arterial hypertension targeted therapy: Beyond vasodilators

1 April 2025
Author(s): Si Pang, Haobo Huang, Hui Luo, Huibing Peng, Mingxing Wu

Pulmonary arterial hypertension (PAH) is a multifaceted and lethal disorder characterized by elevated pulmonary pressures and right ventricular failure, ultimately leading to premature death. With an... more

Thromboembolic and bleeding risks in patients on anticoagulation after noncardiac surgery for malignancy

1 April 2025
Author(s): Satoshi Higuchi, Yusuke Kabeya, Hiroshi Hasegawa, Hideaki Yoshino, Takeaki Matsuda

Atrial fibrillation (AF) and pulmonary embolism/deep vein thrombosis (DVT), all of which have an indication for anticoagulation, are observed commonly in patients with malignancy, regardless of... more

Refining the predictive value of nasal pressure swing in acute hypoxemic respiratory failure management

27 March 2025
Author(s): Danyang Liu

With great interest, we read about the study by Tonelli et al. on the predictive value of nasal pressure swing (Pnose) in assessing respiratory support dependency among patients with acute hypoxemic... more

Efficacy and safety of crinecerfont for the treatment of congenital adrenal hyperplasia

25 March 2025
Author(s): André Saad Cleto, João Matheus Schirlo, Janete Machozeki, Camila Marinelli Martins

Congenital adrenal hyperplasia (CAH) is an autosomal recessive genetic disease that leads to an enzyme deficiency, the main consequence of which is the reduction in the production of cortisol and... more

Clinical factors associated with limited therapeutic implementation in patients with heart failure and reduced ejection fraction hospitalized in internal medicine wards

24 March 2025
Author(s): Arianna Bartoli, Mattia Donadoni, Elisa Ceriani, Chiara Cogliati, DRY-OFF study group

Heart failure (HF) affects over 56 million people globally and accounts for 1–2 % of all hospitalizations in the Western world [1]. Prevalence of HF rises with age, as patients over 70 years of age... more

Accuracy of glomerular filtration rate estimating equations in systemic sclerosis

19 March 2025
Author(s): Chiara Pellicano, Valeria Carnazzo, Umberto Basile, Edoardo Rosato, Antonietta Gigante, Scleroderma Renal Study Group

Kidney involvement in Systemic Sclerosis (SSc) is primarily due to vasospasm induced by renal Raynaud's phenomenon, leading to hypoxia, impaired angiogenesis and microvascular dysfunction. Renal... more

Serum angiopoietin-like protein 4 levels correlate with hypertriglyceridemia and renal function decline in pediatric patients with lupus nephritis

17 March 2025
Author(s): Wangqiu Gong, Guanyu Li, Di Lu, Ming Liu, Xia Gao

Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE), with up to 70 % of pediatric SLE patients experiencing kidney involvement, and LN also aggravates the... more

Atrial fibrillation ablation versus medical therapy in heart failure with preserved ejection fraction

14 March 2025
Author(s): Xin Liu, Wulamiding Kaisaier, Kai Chen, Beibei Yu, Wengen Zhu

Heart failure with preserved ejection fraction (HFpEF) is a multifaceted and increasingly prevalent clinical syndrome that presents significant challenges in both diagnosis and management. Its... more

Why did it take forty years to uncover long-term fluoroquinolone associated toxicities?

14 March 2025
Author(s): Charles L Bennett, Linda Martin, Gretchen LeFever Watson, Steven T Rosen, David Aboulafia, SONAR Pharmacovigilance Group

Since fluoroquinolones (FQs) were introduced in 1986, 1 billion courses have been administered [1]. Safety announcements have been disseminated since 2016 in the United States (US), European Union (... more

Diastolic blood pressure variability predicts adverse outcomes in stabilized acute heart failure patients

13 March 2025
Author(s): Hyung Joon Joo, Soon Jun Hong, Cheol Woong Yu, Yong Hyun Kim, Eung Ju Kim

Blood pressure variability; heart failure; Cardiovascular outcome; Diastolic blood pressure

Utilizing D-dimer levels for predicting survival probability in unplanned hospital admissions: Insights from a 5-year nationwide population-based register study

4 March 2025
Author(s): Mikkel Brabrand, Marianne Fløjstrup, Søren Bie Bogh, Tim Cooksley, Christian Hans Nickel

Although the most common clinical use of D-dimer measurements is to rule out thromboembolic disease [1], it is also elevated in several other serious illnesses and raised levels are associated with a... more

Why doesn't sepsis rhyme with Internal Medicine?

26 February 2025
Author(s): Chiara Casarsa, Filippo Mearelli, Alessio Nunnari, Francesca Spagnol, Stefano Di Bella

I am writing to share some reflections on the challenges that internists face in the management of sepsis, a complex and multifactorial condition requiring a multidisciplinary approach. Despite the... more

Hemoglobin levels for the diagnosis of polycythemia vera: How high is high enough?

17 February 2025
Author(s): Ugur Koca, Enes Seyda Sahiner, Ozge Soyer Kosemehmetoglu, Tekin Guney, Betul Erismis

The World Health Organization (WHO) diagnostic criteria for Polycythemia Vera (PV), initially published in 2001 and 2008, were last revised in 2016. According to these criteria, evaluation for PV is... more

Evolution of care pathways in clinical practice guidelines for heart failure

17 February 2025
Author(s): Quirós-López R, Estupiñán-Romero F, Millán-Ortuondo E, Bernal-Delgado E, Jiménez-García N

In the context of the increasing complexity of patients with heart failure (HF) and the rapid expansion of available therapies, clinical practice guidelines (CPGs) have become indispensable for... more

Direct oral anticoagulants guided by CHA2DS2-VASc stratification for stroke prevention in patients with device-detected atrial fibrillation

15 February 2025
Author(s): Zhengbiao Xue, Song Liao, Haiye Fan, Yu Shen, Zhi Nie

Atrial fibrillation (AF) significantly increases stroke risk, with affected individuals having a fivefold higher likelihood compared to the general population. Oral anticoagulation (OAC),... more

Sodium-glucose cotransporter2 inhibitor-associated ketoacidosis in nondiabetic patients

14 February 2025
Author(s): Claudia Stöllberger, Raphael Wilfing, Josef Finsterer, Birke Schneider

Sodium-Glucose Cotransporter2-inhibitors (SGLT2i) were developed for treating diabetic patients. Empagliflozin and dapagliflozin, frequently prescribed SGLT2i, are now also recommended for... more

Factor XI/XIa inhibitors versus direct oral anticoagulants in atrial fibrillation

9 February 2025
Author(s): Shan Zeng, Wulamiding Kaisaier, Chen Liu, Wengen Zhu

Dear Editor,

Original Article

Modulation of hypoxia-sensitive non-coding RNAs following continuous positive airway pressure therapy in obstructive sleep apnea in peripheral blood

2 July 2025
Author(s): Francesco Fanfulla, Veronica Barbi, Tiziana Bachetti, Roberto Maestri, Elena Robbi, Alessia Mongelli, Teresa Lucia Aloi, Caterina Pronzato, Michela Gottardi Zamperla, Simona Greco, Fabio Martelli, Maria Teresa La Rovere, Carlo Gaetano

Obstructive sleep apnea (OSA) is a chronic clinical condition characterized by recurrent apnea or hypopnea during sleep, leading to intermittent hypoxemia, arousal, and sleep fragmentation. OSA... more

Sex-related differences in the management and outcome of intubated adults with community-acquired pneumonia in Europe: A multicentre study

1 July 2025
Author(s): Nicolas Garin, Despoina Koulenti, Virginie Prendki, Jordi Rello

Sex and gender are increasingly recognized determinants in the epidemiology, clinical presentation, management, response to treatment, and prognosis of chronic and acute diseases [1]. Sex refers to... more

Incidence and prevalence of systemic lupus erythematosus across Italian referral centers and its clinical burden in terms of disease severity, treatment and hospitalization: The ESCULAPIO study

28 June 2025
Author(s): Irene Mattioli, Michela Gasparotto, Alberto Bergamini, Alessandra Bortoluzzi, Francesco Ciccia, Fabrizio Conti, Maria Antonietta D'agostino, Micaela Fredi, Roberto Giacomelli, Florenzo Iannone, Ilaria Mormile, Matteo Piga, Luca Quartuccio, Gian Domenico Sebastiani, Chiara Tani, Angelo Vacca, Margherita Zen, Alessandra Bettiol, Giacomo Emmi, ESCULAPIO consortium

Systemic Lupus Erythematosus (SLE) is a multifaceted systemic autoimmune disorder distinguished by a diverse array of clinical manifestations that can potentially impact any organ or system in the... more

Neurologic and psychiatric disorders following correction of profound hyponatremia - A cohort study

25 June 2025
Author(s): Henrik Falhammar, Mikael Andersson Franko, Jonatan D. Lindh, Jakob Skov, Buster Mannheimer

Hyponatremia, defined as a serum sodium concentration <135 mmol/L, is the most common electrolyte imbalance, seen in 15–20 % of all acute hospital admissions [1]. Women, elderly, and individuals... more

Survival effect of early high-flow nasal oxygen after the extubation of patients in the intensive care unit

24 June 2025
Author(s): Atsushi Ishihara, Hideshi Okada, Teruki Mori, Takashi Yoshizane, Kentaro Morishita, Takuji Yamamoto, Izumi Toyoda, Toshiyuki Noda

Spontaneous awakening trial (SAT) and spontaneous breathing trial (SBT) protocols for mechanically ventilated patients in the intensive care unit (ICU) have been shown to reduce the duration of... more

Prognostic value of N-terminal prohormone B-type natriuretic peptide modified by renal function in patients with acute heart failure

21 June 2025
Author(s): Rui Zhu, Yaoyao Wang, Lili Liu, Xuejiao Liu, Zhanyuan Chen, Yu Wei, Weifeng Lin, Lihua Zhang, Guangda He, Jianfang Cai

Heart failure (HF), as the final phase of various cardiovascular disorders, imposes a formidable global healthcare challenge due to its diverse morbidity and high rate of mortality [1]. HF and kidney... more

Determinants of time to first palliative care consultation in hospitalized patients with advanced or terminal illness – A retrospective analysis

19 June 2025
Author(s): Christopher Paschen, Franziska Ecker, Patrick Haider, Claudia Wenzel, Eva Katharina Masel

The Yentl Syndrome, a term coined by Dr. Bernadine Healy in 1991, refers to the phenomenon that women are less likely to receive accurate diagnosis and treatment because their symptoms do not align... more

Blood pressure values in healthy normal weight children and adolescents in eight European countries: auscultatory and oscillometric measurements

19 June 2025
Author(s): Lurbe E, Regueiro-Ons C, Mancia G, Düzova A, Erdine S, Herceg-Cavrak V, Kulaga Z, Litwin M, Pall D, Petricevic N, Seeman T, Simão C, Stabouli S, Redon J, González López-Valcarcel B

The importance of high blood pressure (BP) as a modifiable risk factor for early disability and death is well established [1]. Although the majority of adverse outcomes occur in adulthood, high BP is... more

Long-term quality of life after sleeve gastrectomy vs Roux-en-Y Gastric Bypass in patients with severe obesity: Results from the SleeveBypass multicentre randomised controlled trial

19 June 2025
Author(s): J.W.H. ‘t Hart, B.J. Noordman, E. Birnie, J.F. Smulders, S. Nienhuijs, M. Dunkelgrün, J.F. Zengerink, I.A.M. Friskes, G.H.H. Mannaerts, C. Verhoef, J.A. Apers, L.U. Biter

Obesity is a chronic condition and a worldwide problem that poses health risks, reduces quality of life (QoL), contributes to psychosocial issues and increases public healthcare costs [1]. While,... more

Efficacy and safety of once-daily oral semaglutide in patients with heart failure with preserved ejection fraction, type 2 diabetes and obesity: a real-world study

14 June 2025
Author(s): Alicia Trenas, Miguel A. Pérez-Velasco, Maria-Rosa Bernal-López, María-Dolores López-Carmona, Juan J. Gómez-Doblas, María-Dolores Martínez-Esteban, Oumayma Bouarich, Natalia García-Casares, Diego Fernández-García, María-Dolores García de Lucas, Ricardo Gómez-Huelgas, Luis M. Pérez-Belmonte

Heart failure with preserved ejection fraction (HFpEF) is a complex and multifactorial heart disease. It has become the most common type of heart failure (HF), which can be explained in part by its... more

Identification of risk factors for permanent visual loss in patients with giant cell arteritis

14 June 2025
Author(s): Roser Solans-Laqué, Begoña de Escalante-Yanguela, Eva Fonseca, Guadalupe Fraile, Ferran Martínez-Valle, Luis Caminal, Manuel Monteagudo, Mercedes Pérez-Conesa, Borja Gracia-Tello, Monica Abdilla, Sergio Prieto-González, Aleida Martínez-Zapico, Borja de Miguel-Campo, Jaume Mestre-Torres, REVAS-Registry, from the Systemic Autoimmune Diseases Study Group (GEAS) of the Spanish Society of Internal Medicine (SEMI)

Giant cell arteritis (GCA) is the most common systemic vasculitis affecting older people in Western countries, being more prevalent in females [1–4]. Vascular inflammation predominantly affects the... more

Current epidemiology, risk factors and influence on prognosis of multidrug resistance in Klebsiella spp. bloodstream infection. Insights from a prospective cohort

12 June 2025
Author(s): Jorge Calderón-Parra, María Teresa Carretero-Henriquez, Gabriela Escudero, Elena Suances-Martin, Marta Murga de la Fuente, Patricia González-Merino, Ane Andrés-Eisenhofer, Ana Visedo-Colino, Ana Rodríguez, Ana Rojo-Reyes, Itziar Diego-Yagüe, Andrea Gutiérrez-Villanueva, Isabel Sánchez-Romero, Antonio Ramos-Martinez

Klebsiella spp. are the third most common cause of bloodstream infections, only after Escherichia coli and Staphylococcus aureus, both in the community and nosocomial infections [1]. Usually arising... more

Systemic markers of inflammation and immune activation in patients with obstructive sleep apnea and paroxysmal atrial fibrillation

12 June 2025
Author(s): TE Hunt, GM Traaen, L Aakerøy, B Øverland, C Bendz, AE Michelsen, S Steinshamn, KH Haugaa, OG Anfinsen, P Aukrust, K Broch, H Akre, JP Loennechen, L Gullestad, T Ueland

Sleep apnea and AF are both associated with adverse cardiovascular outcomes [1,2]. Obstructive sleep apnea (OSA) is more prevalent in patients with atrial fibrillation (AF) than in patients with... more

Gamma-glutamyltransferase independently predicts mortality and heart failure hospitalization in cardiac transthyretin amyloidosis

11 June 2025
Author(s): Alberto Aimo, Vincenzo Castiglione, Daniela Tomasoni, Giovanni Battista Bonfioli, Giorgia Panichella, Giulio Sinigiani, Alessandro Lupi, Aldostefano Porcari, Navneet Kaur, Marco Merlo, Alberto Cipriani, Gianfranco Sinagra, Maria Franzini, Giuseppe Vergaro, Michele Emdin

Transthyretin cardiac amyloidosis (ATTR-CA) is an infiltrative cardiomyopathy caused by extracellular deposition of misfolded transthyretin (TTR) fibrils within the myocardium, leading to progressive... more

The approach to triglyceride levels in patients with coronary heart disease

11 June 2025
Author(s): Ilay Shani, Avishay Elis

Hypercholesterolemia is one of the major modifiable cardiovascular risk factors, while current guidelines mark the low-density lipoprotein cholesterol (LDL-C) levels as the primary target of... more

Hypochloremia in chronic and acute heart failure scenarios: Prevalence and risk factors

11 June 2025
Author(s): Pau Llàcer, Marta Cobo Marcos, François Croset, Isabel Zegrí-Reiriz, Rafael de la Espriella, Jara Gayán Ordás, Aleix Fort, Jorge Rubio-Gracia, Zorba Blázquez-Bermejo, Ana Méndez, Adriana Rodríguez, Pedro Caravaca-Pérez, Josep Comín-Colet, Jose Luis Morales-Rull, Luis Manzano, Julio Núñez

Traditionally, sodium and potassium disorders have been considered the most relevant ionic disturbances in heart failure (HF)., [1] However, in recent years, hypochloremia has emerged as a critical... more

Long-term secondary prevention with colchicine in patients with CAD: an updated systematic review and meta-analysis

6 June 2025
Author(s): Patrizia Boracchi, Giuseppe Marano, Ester Luconi, Claudio Cimminiello

Randomized clinical trials (RCTs) for the prevention of vascular events in patients with coronary artery disease (CAD) over the past decade have clearly demonstrated that colchicine is able to reduce... more

Different loop diuretic dosing and administration in acute heart failure (DIUR-AHF): a multicenter prospective observational open-label study

3 June 2025
Author(s): Alberto Palazzuoli, Filippo Pirrotta, Andrea Stefanini, Antonio Pagliaro, Paolo Severino, Andrea D’Amato, Dario Vizza, Andrea Salzano, Giulia Crisci, Marco Guazzi, Simone Frea, Guido Pastorini, Mauro Feola, Francesco Fedele

Acute heart failure (AHF) is a clinical syndrome characterized by progressive or sudden and rapid onset of signs and symptoms of HF, related to hemodynamic and neurohormonal derangement [1,2]. AHF... more

Prevalence of malnutrition and its impact on clinical outcomes in internal medicine wards: The SIMI-NUTRO study

2 June 2025
Author(s): Maurizio Muscaritoli, Maria Ida Amabile, Carmen Gallicchio, Giovanni Imbimbo, Caterina Conte, Elisa Ceriani, Antonello Pietrangelo, Elena Corradini, Giuseppe Mandraffino, Gaetano Serviddio, Silvio Buscemi, Ferdinando Carlo Sasso, Clara Balsano, Alberto Moggi Pignone, Alessio Molfino

Screening for malnutrition is recommended for all hospitalized patients and can be performed using tools such NRS-2002, MUST, and MNA-SF. Patients at risk should undergo further evaluation for the... more

Recombinant human hyaluronidase-facilitated subcutaneous immunoglobulin (hf-SCIg) for inflammatory myositis: a multicenter retrospective real-world observational study

31 May 2025
Author(s): Adalgisa Palermo, Edoardo Biancalana, Alessandra Bettiol, Luisa Brussino, Corrado Campochiaro, Valentina Canti, Marco Capassoni, Chiara Cardelli, Linda Carli, Lorenzo Dagna, Maria Giovanna Danieli, Giacomo De Luca, Serena Guiducci, Marta Mosca, Patrizia Rovere-Querini, Maria Letizia Urban, Giacomo Emmi,  

The spectrum of idiopathic inflammatory myositis (IIM) includes a heterogeneous group of diseases that share chronic inflammation of skeletal muscle, mainly characterized by proximal muscle weakness... more

Latent class analysis identifies novel coeliac disease subgroups with distinctive clinical features: a multicentric study

30 May 2025
Author(s): Marco Vincenzo Lenti, Daniele Pala, Nicola Aronico, Arianna Dagliati, Paola Ilaria Bianchi, Giovanni Santacroce, Silvana Quaglini, Giordano Lanzola, Gino Roberto Corazza, Antonio Di Sabatino, Coeliac Disease Study Group

Coeliac disease (CD) is a chronic, lifelong, immune-mediated disorder causing villous atrophy in genetically susceptible individuals upon the ingestion of gluten in the diet [1,2]. It has been... more

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: A comprehensive review of cases across different ethnicities

28 May 2025
Author(s): Yixiang Yves-Jean Zhu, David Benjamin Beck, Yannick Dieudonné, Sophie Georgin-Lavialle

Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome is a recently described somatic autoinflammatory disease [1]. A genetic mutation in the UBA1 gene results in a deficiency of... more

Natural history of the severe subtype of MYH9-related disease (Epstein syndrome)

28 May 2025
Author(s): Kazuma Shinno, Shinji Kunishima, Atsushi Sakamoto, Toru Uchiyama, Akira Ishiguro

Congenital thrombocytopenia, giant platelets, and Döhle-like bodies in granulocytes characterize MYH9-related disease (MYH9-RD). Clinical manifestations include deafness, nephritis, and cataracts [1,... more

Metabolic dysfunction-associated steatotic liver disease (MASLD). Assessing metabolic dysfunction, cardiovascular risk factors, and lifestyle habits

27 May 2025
Author(s): Hala Abdallah, Mohamad Khalil, Ewa Awada, Elisa Lanza, Agostino Di Ciaula, Piero Portincasa

Steatotic liver disease (SLD), a hallmark of metabolic dysfunction, is closely associated with atherosclerotic cardiovascular disease (ASCVD). This study investigated gender differences, metabolic... more

Effectiveness and safety of telemonitoring compared with standard of care in people with type 2 diabetes treated with insulin: a national multicenter randomized controlled trial

24 May 2025
Author(s): Stine Hangaard, Thomas Kronborg, Sarah Rüdiger Cohen, Allan Kofoed-Enevoldsen, Camilla Heisel Nyholm Thomsen, Tinna Björk Aradóttir, Sika Nuunu Slobodziuk Kristensen, Anne Kaas, Henrik Bengtsson, Peter Vestergaard, Claus Dethlefsen, Ole Hejlesen, Morten Hasselstrøm Jensen

The trial demonstrated that telemonitoring is superior to standard of care in T2D for improving glycemic control.

PEPPER – Prehospital prediction in pulmonary embolism: The association of the national early warning score with mortality, thrombolysis, and clinical outcomes

12 May 2025
Author(s): Alexandra J. Lipa, Karin Janata-Schwatczek, Anne E. Merrelaar, Marieke Merrelaar, Max Sterz, Ursula Azizi-Semrad, Christian Schoergenhofer, Harald Herkner, Michael Schwameis, Juergen Grafeneder

Pulmonary embolism (PE) requires careful risk assessment for informed care decisions. We evaluated the value of the National Early Warning Score (NEWS) in patients with PE when used by emergency... more

New onset left atrial dilatation in the general population: A quarter-century follow-up

11 May 2025
Author(s): Cesare Cuspidi, Rita Facchetti, Fosca Quarti-Trevano, Raffaella Dell’Oro, Andrea Faggiano, Giuseppe Mancia, Guido Grassi

Left atrial (LA) anatomical remodeling, detected by measuring the diameter or, more comprehensively, the volume with echocardiography is regarded as a marker of left ventricular (LV) diastolic... more

The effects of sleep improving interventions in medical hospital wards: the WEsleep study - A randomized clinical trial

9 May 2025
Author(s): C.J. de Gans, A.J.G. Meewisse, E.S. van den Ende, M.L. van Zuylen, P.W.B. Nanayakkara, J. Hermanides, D.J. Stenvers, WE Sleep Study Group

Multiple studies indicate that sleep in hospitals is suboptimal.1,2 Disturbed and inadequate sleep occurs in 48 to 77 % of hospitalized patients.3,4 Sleep-disturbing factors in hospitals include... more

Difficult-to-treat rheumatoid arthritis among elderly patients from the KOBIO registry

5 May 2025
Author(s): Ju-Yang Jung, Eunyoung Lee, Ji-Won Kim, Chang-Hee Suh, Kichul Shin, Jinhyun Kim, Hyoun-Ah Kim

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by systemic inflammation the primarily affects the joints, resulting in pain, swelling, stiffness, and functional impairment [... more

Cost-effectiveness of daily home haemodialysis versus in-centre haemodialysis: A propensity score matching analysis based on real-world data from the French healthcare system

3 May 2025
Author(s): Guy Rostoker, Jean-Jacques Dumas, Benoît Thomé, Victor-Alexandre Aragno, Michel Thomas, Bernard Canaud

Home haemodialysis (HD) offers several advantages over conventional in-centre 3-times-weekly HD which have been summarised in recent reviews [1,2]. Among them are better preservation of health-... more

NT-proBNP to guide risk stratification after cardiac rehabilitation in patients with ST-segment elevation myocardial infarction

1 May 2025
Author(s): Nerea Pérez-Solé, Elena de Dios, José Gavara, César Ríos-Navarro, Víctor Marcos-Garces, Héctor Merenciano, Josefina I Climent, Laura López-Bueno, Alfonso Payá, Rafael de la Espriella, Antoni Bayés-Genís, Manuel Jiménez-Navarro, Francisco Marín, Julio Núnez, Juan Sanchis, Vicente Bodí

The use of N-terminal pro-brain natriuretic peptide (NT-proBNP) after ST-segment elevation acute myocardial infarction (STEMI) is unclear. We evaluated its prognostic significance after post-STEMI... more

Burden and risk factors for 30-day readmission and mortality after CAP hospitalization: A population-based cohort study

22 April 2025
Author(s): Fabian Reichel, Falko Tesch, Saskia Berger, Martin Seifert, Dirk Koschel, Jochen Schmitt, Martin Kolditz

Community-acquired pneumonia (CAP) is considered the world’s most fatal infectious disease and is associated with a fundamental burden in healthcare and society [1]. 30-day mortality ranges from <... more

ICD-10-CM coding uncovers the gap between serological and clinically identified coeliac disease prevalence: A population-based study

22 April 2025
Author(s): Ivan Villar-Balboa, Meritxell Regí-Bosque, Jesús Almeda-Ortega, Oriol Cunillera-Puértolas, Yolanda Rando-Matos, Ivan Valencia-Pedraza, Montserrat Merino-Audí, Ivan Arapovic-Amat, Natalia Sánchez-Gómez, Ana Fernández-Gómez, Betlem Salvador-González, Emma Sudrià-Lopez, Albert Martín-Cardona, Fernando Fernández-Bañares, Maria Esteve

Coeliac disease (CD) is one of the most common lifelong disorders and affects people of all ages worldwide [1]. A systematic review and meta-analysis reported that the global CD seroprevalence was 14... more

Derivation and validation of the Caravaggio score for the risk stratification for recurrence in patients with cancer-associated venous thromboembolism

18 April 2025
Author(s): Maria Cristina Vedovati, Andrés J. Muñoz Martín, Michela Giustozzi, Paula Jimenez-Fonseca, Cecilia Becattini, Maria Purificación Martínez del Prado, Francesco Dentali, Menno V. Huisman, Alexander T. Cohen, Rupert Bauersachs, Alberto Carmona-Bayonas, Giancarlo Agnelli

Cancer associated venous thromboembolism (CAT) has a high risk of recurrence and treatment-emergent bleeding [1–4]. The identification of risk factors for venous thromboembolic (VTE) recurrence and... more

Mortality and causes of death in patients hospitalized with hyponatremia – a propensity matched cohort study

15 April 2025
Author(s): Buster Mannheimer, Jonatan D. Lindh, Issa Issa, Mikael Andersson Franko, Henrik Falhammar, Jakob Skov

Hyponatremia is the commonest electrolyte imbalance, affecting more than one in 10 patients admitted to hospital [1]. Women, elderly, and individuals with comorbid burdens are generally at greater... more

Intermediate Care Units in Internal Medicine

4 April 2025
Author(s): Ciro Canetta, Silvia Accordino, Fabiola B. Sozzi

A cornerstone of the reorganization challenge of hospital systems has been provided by the Progressive Patient Care (PPC) model [1], lying on the concept of pooling patients around the acuity of... more

The role of an intermediate care unit in reducing intensive care unit admissions and improving patient outcomes in internal medicine: A quasi-experimental study

28 March 2025
Author(s): Gianni Turcato, Arian Zaboli, Paolo Ferretto, Lucia Filippi, Daniela Milazzo, Marta Parodi, Michael Maggi, Alessandro Cipriano, Massimo Marchetti, Christian Josef Wiedermann, Lorenzo Ghiadoni

The optimal management of non-intensive critical patients remains a debated topic. This debate is further complicated by the fact that Intensive Care Units (ICUs) bed availability is regulated by... more

Excess mortality of critically ill patients aged ≥90 years in intensive care units: A retrospective cohort study

25 March 2025
Author(s): Jan Frederic Weller, Kevin Roedl, Rikus Daniels, Pauline Theile, Jakob Müller, Frederik Peters, Claudia Lengerke, Carsten Bokemeyer, Liesbeth de Wreede, Stefan Kluge, Maximilian Christopeit

We live in an aging society, which is foremost caused by increasing life expectancy, next other factors. In concordance, at least the sheer number of older patients increases, too. When those older... more

R202Q homozygosity of Mediterranean fever gene is associated with atypical clinical phenotype of familial Mediterranean fever

21 March 2025
Author(s): Dimitrios Sagris, Christina Antoniadou, Nikolaos K. Gatselis, Efstratios Gavriilidis, Vasileios Papadopoulos, Sarah Georgiadou, Stella Gabeta, Victoria Tsironidou, Konstantinos P. Makaritsis, Panagiotis Skendros, Eirini I. Rigopoulou, Konstantinos Ritis, George N. Dalekos

Autoinflammatory disorders represent a heterogenous group of genetic or acquired systemic diseases characterized by febrile episodes and chronic inflammation, due to dysregulation of innate immunity... more

Review Article

When inflammatory bowel disease meets pregnancy

19 June 2025
Author(s): Shiqing Zhao, Shengpu Zhou, Junmei Wang, Yanyan Shi

Inflammatory bowel disease (IBD) is a group of chronic and relapsing inflammatory conditions of the gastrointestinal tract with two major forms: Crohn’s disease (CD) (affecting any segment of the... more

Point of care ultrasound: focus on evidence for a critical appraisal

16 June 2025
Author(s): E. Ceriani, R. Schiavon, L. La Cava, C. Ruscitti, C. Cogliati

The term point of care ultrasound (POCUS) refers to a sonographic examination directly performed at the patient’s bedside, ideally by the treating physician, to interpret and integrate images into... more

A holistic view of SGLT2 inhibitors: From cardio-renal management to cognitive and andrological aspects

13 June 2025
Author(s): Rossella Cannarella, Michele Rubulotta, Vittorio Cannarella, Sandro La Vignera, Aldo E. Calogero

Type 2 diabetes mellitus (T2DM) is a multifactorial disease associated with complications that significantly affect both survival and quality of life, including cardiovascular, renal, cognitive,... more

Artificial intelligence and the electrocardiogram: A modern renaissance

20 May 2025
Author(s): Stefano Palermi, Marco Vecchiato, Fu Siong Ng, Zachi Attia, Youngjin Cho, Matteo Anselmino, Gaetano Maria De Ferrari, Andrea Saglietto, on behalf of the International AI-ECG Working Group

The electrocardiogram (ECG) is a fundamental, non-invasive diagnostic tool in cardiology, widely accessible and crucial for assessing the heart's electrical and structural conditions [1].... more

Cogan's syndrome. A comprehensive review

17 May 2025
Author(s): Nabil Belfeki, Nouha Ghriss, Sonia Kammoun, Arsene Mekinian

Cogan Syndrome (CS) is a rare systemic vasculitis affecting the inner ear and the eye with systemic manifestations described first in 1945 by David G. Cogan as a “syndrome of non-syphilitic... more

The medical ward round: evidence, pitfalls, and tips

17 May 2025
Author(s): Stefano Bassetti, Armon Arpagaus, Flavio Gössi, Christoph Becker, Sabina Hunziker

Ward rounds are pivotal for patient-centered care and bedside teaching. In today’s hospitals, care is provided by multidisciplinary and multiprofessional teams. To conduct an effective and efficient... more

Drug-induced hyponatremia in clinical care

5 May 2025
Author(s): Buster Mannheimer, Jonatan D. Lindh, Cecilia Bergh Fahlén, Issa Issa, Henrik Falhammar, Jakob Skov

Over the last decades, advances in understanding of previously described associations have important implications for diagnosis and workup of hyponatremia. In addition, new drug groups potentially... more

Tailoring non-invasive respiratory supports in acute hypoxemic respiratory failure: A practical approach for clinicians

2 May 2025
Author(s): Maria Laura Vega Pittao, Stefano Nava, Nicholas S Hill, Lara Pisani

The use of non-invasive respiratory support (NIRS) for acute respiratory failure (ARF), particularly hypoxemic respiratory failure, has advanced in recent years, especially during the COVID-19... more

A physico-chemical explanation for the litho-protective effects of obeticholic acid in low phospholipid-associated cholelithiasis

16 April 2025
Author(s): Karel J. van Erpecum, Piero Portincasa, Gerard P. van Berge Henegouwen, Antonio Moschetta

Prevalence of gallstones in the adult European population is ̴20 % (mostly cholesterol stones in the gallbladder). Obesity, metabolic syndrome, type 2 diabetes, female sex, pregnancy, multiparity and... more

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