Polymyalgia rheumatica (PMR) is a relatively common disease among European patients older than 50 years [1]. It is an inflammatory disorder characterized by severe pain and stiffness affecting mainly the shoulders and pelvic girdle that may be also associated with systemic features [2].PMR is often a tricky condition in which diagnosis and differentiation from other entities can be challenging. PMR and giant cell arteritis (GCA) are often concurrent and overlapping conditions [3]. In fact, in some cases PMR is the presenting manifestation of GCA, particularly in patients with predominant extracranial large-vessel involvement (LV-GCA) [1,4].