Published: 27 December 2021
Author(s): Andrés González-García, José Luis Callejas-Rubio
Issue: March 2022
Section: Clinical Insights

Systemic sclerosis (SSc) is an autoimmune systemic disease of unknown origin, characterized by sclerosis of the skin and internal organs associated with endothelial dysfunction, immune dysregulation, and autoantibody [1]. The most common manifestations are Raynaud's phenomenon (RP), digital ulcers, interstitial lung disease (ILD), pulmonary arterial hypertension (PAH), gastrointestinal disorders, scleroderma renal crisis (SRC), heart problems, and musculoskeletal symptoms. Nevertheless, SSc may be a clinically heterogeneous disease that ranges from a milder form to more rapid widespread internal organ involvement with different clinical features at onset.


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