Good syndrome is a rare adult-onset immunodeficiency syndrome, typically characterized by thymoma and hypogammaglobulinemia. Its clinical manifestations are highly variable, and concurrent non-infectious organ involvements secondary to immune dysregulation have been increasingly recognized, such as myasthenia gravis and immune-mediated cytopenias [1]. Among them, gastrointestinal manifestations resembling inflammatory bowel diseases or celiac disease were only described in case reports or small series; however, their clinical features, endoscopic and histologic findings remain largely undefined, and the optimal treatment as well as long-term outcomes are also not established given the rarity.