Sarcoidosis is a chronic multisystem inflammatory disorder characterized by noncaseating granulomas. The exact etiology and underlying mechanisms of sarcoidosis have not been fully elucidated. It is postulated that environmental antigenic stimulation of CD4+ T cells through the major histocompatibility complex (MHC) II receptor leads to the production of inflammatory cytokines and macrophage activation [1,2]. Macrophage activation causes the release of cytokines, like tumor necrosis factor-alpha (TNF-α), which in turn stimulates the activation of more CD4+ T cells [3,4].
