Published: 10 May 2019
Author(s): Paolo Gallo, Antonio De Vincentis, Claudio Pedone, Alessandro Nobili, Mauro Tettamanti, Umberto Vespasiani Gentilucci, Antonio Picardi, Pier Mannuccio Mannucci, Raffaele Antonelli Incalzi, REPOSI Investigators
Issue: May 2019
Section: Original article

Polypharmacy is very common in older patients and may be associated with drug-drug interactions. Hepatic cytochrome P450 (notably 3A4 subtype, CYP3A4) is a key enzyme which metabolizes most drugs; P-glycoprotein (P-gp) is a transporter which significantly influences distribution and bioavailability of many drugs. In this study, we assess the prevalence and patterns of potential interactions observed in an hospitalized older cohort (Registro Politerapia Società Italiana di Medicina Interna) exposed to at least two interacting drugs involving CYP3A4 and P-gp at admission, during hospitalization and at discharge.

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