Frailty is a biological syndrome of decreased physiological reserves with incremented vulnerability to stressors and its prevalence among older adults has been estimated at ∼10% [1]. Hypertension is a prevailing comorbidity in older adults and its incidence increases with age [2,3]. Vascular dementia (VD) and Alzheimer's Disease (AD) are among the main causes of dementia and/or mild cognitive impairment (MCI) in older adults with or without frailty [4]. Despite these shreds of evidence and despite the emerging interest in geriatric conditions, the actual correlation between physical and cognitive impairment in physically frail patients remains unclear.