Published: 5 January 2023
Author(s): Dimitrios Patoulias
Issue: May 2023
Section: Letter to the Editor

Macrophage activation syndrome (MAS) is a serious, life-threatening, complication, characterized by generalized, multisystem, inflammatory response, which can affect almost every organ system, resulting in multiple organ dysfunction [1]. Rheumatic diseases, infections, hematologic malignancies, and certain drug classes have been identified as potential triggers of MAS [1,2]. Interleukin (IL)−1β over-secretion provokes to cytokine storm, involving IL-6, IL-18 and interferon-γ, which contribute to multiple organ dysfunction [2].


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