The use of more than one drug in the initial management of hypertension under certain instances has been recognized as paramount and is featured in several clinical guidelines for high blood pressure management and treatment, including those in the United States, Canada, Latin America, the United Kingdom, and Europe [1–5]. In fact, the European Guidelines states: “…the most effective evidence-based treatment strategy to improve BP control is one that: (i) encourages the use of combination treatment in most patients, especially in the context of lower BP targets; (ii) enables the use of single-pill combinations therapy for most patients, to improve adherence to treatment; and (iii) follows a treatment algorithm that is simple, applies to all patients, and is pragmatic, with the use of single-pill combinations therapy as initial therapy for most patients, except those with BP in the high–normal range and in frail older patients” [2].
