Pre-frailty is a condition that precedes frailty; in 2001, Linda Fried and colleagues defined pre-frailty as the presence of 1 or 2 out of the 5 Fried criteria [1]. Hence, pre-frail older adults represent an intermediate category between normal and frail older adults. Comorbidities are known to play a pivotal role in frailty, in addition to contributing to increasing healthcare costs [2–4]. Hypertension is one of the most common conditions in pre-frailty, and its role in the onset of frailty remains debated [5–7].
