Hyperuricemia and hypertension are important risk factors for cardiovascular disease (CVD), which is the leading cause of death in China and accounts for more than 40% of all deaths in both rural and urban areas [1]. Although the significant positive correlation between hyperuricemia and hypertension has been documented [2–6], it is still unknown which one is the precursor or whether the temporal relationship between them is bidirectional. Therefore, it is necessary to clarify the temporal relationship between them in order to provide an early and effective prevention strategies for preventing CVD.
