Published: 1 March 2024
Author(s): Albrecht Betrains, Lien Moreel, Catharina M. Mulders-Manders, Paul G. Auwaerter, Joaquim Torné-Cachot, Friedrich Weitzer, Teruhiko Terasawa, Kim H. Ly, Verena Schönau, Daniel Blockmans, William F. Wright, Chantal Rovers, Steven Vanderschueren
Issue: May 2024
Section: Original Article

Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are two clinical syndromes that are separated by an arbitrary temperature threshold. They share a common spectrum of underlying causes, which are typically categorized as infectious disorders, malignancies, noninfectious inflammatory disorders, and miscellaneous disorders [1]. The most recent definition defines FUO as an illness with a 3-week duration, fever of ≥38.3 °C on several occasions, and uncertain diagnosis despite a predefined work-up [2].

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