Published: 8 March 2024
Author(s): Emma Diletta Stea, Giuseppina D'Ettorre, Adele Mitrotti, Loreto Gesualdo
Issue: May 2024
Section: Review Article

The Complement System is an evolutionarily conserved component of immunity that plays a key role in host defense against infections and tissue homeostasis. However, the dysfunction of the Complement System can result in tissue damage and inflammation, thereby contributing to the development and progression of various renal diseases, ranging from atypical Hemolytic Uremic Syndrome to glomerulonephritis. Therapeutic interventions targeting the complement system have demonstrated promising results in both preclinical and clinical studies.

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