Thickened left ventricle (LV) is the hallmark of amyloid cardiomyopathy (AC) and results from progressive amyloid deposition in the myocardial extracellular space rather than myocyte hypertrophy [1]. When combined with other echocardiographic typical structural and functional features, it may raise suspicion of AC [2,3]. We recently reported an AC prevalence of 28.6 % among subjects with hypertrophic, non-dilatated hearts with preserved LV ejection fraction (EF) and at least one echocardiographic red flag (RF) of AC, identified from an unselected general population, within the “National Survey of Prevalence and Accuracy of Echocardiographic Red Flags of Amyloid Cardiomyopathy in Consecutive Patients Undergoing Routine Echocardiography” (AC-TIVE) study [4].
