Existing studies have illustrated that the coronavirus disease 2019 (COVID-19) infection is an independent risk factor for pulmonary embolism (PE) [1–4]. However, longitudinal trends in incidence of acute PE hospitalizations across different waves of the COVID-19 pandemic is unknown. Therefore, we performed this study to determine trends in incidence of PE hospitalizations and associated mortality in pre-pandemic and pandemic periods with a focus on the Omicron wave.