Published: 17 November 2023
Author(s): Matteo Pagnesi, Filippo Calì, Mauro Chiarito, Davide Stolfo, Luca Baldetti, Carlo M. Lombardi, Daniela Tomasoni, Ferdinando Loiacono, Marta Maccallini, Alessandro Villaschi, Daniele Cocianni, Maria Perotto, Adriaan A. Voors, Daniela Pini, Marco Metra, Marianna Adamo, HELP-HF Registry investigators
Issue: May 2024
Section: Original article

Mitral regurgitation (MR) is the most common valvular heart disease in patients with heart failure (HF) [1]. Left ventricular remodeling, left atrial enlargement, and cardiac dyssynchrony leading to leaflet tethering and/or annular dilatation are the main mechanisms behind secondary MR [2]. Secondary MR is associated with poor outcome in patients with HF and an incremental effect was observed with increasing of MR severity independently from other clinical and echocardiographic parameters [3–7].


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