Published: 24 February 2024
Author(s): Luisa Canè, Remo Poto, Francesco Palestra, Marinella Pirozzi, Seetharaman Parashuraman, Ilaria Iacobucci, Anne Lise Ferrara, Antonello La Rocca, Edoardo Mercadante, Piero Pucci, Gianni Marone, Maria Monti, Stefania Loffredo, Gilda Varricchi
Issue: May 2024
Section: Original Article

The human lung is a remarkable organ that filters up to 10,000 liters of air daily, interfacing with the exposome [1]. Several environmental factors, including airborne pollutants, particulate matter, allergens, and microbial proteins, are sensed and/or metabolized by immune and structural cells of the lung [2]. Macrophages, the predominant immune cells in the human lung [3–6], sense a wide spectrum of signals within their microenvironment. In response to external and endogenous signals, macrophages express genes that confer distinct functional attributes, which can cause disease when inappropriately elicited [7].

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