Published: 30 November 2019
Author(s): Antonis A. Manolis, Theodora A. Manolis, Helen Melita, Niki Katsiki, Antonis S. Manolis

Proton pump inhibitors (PPIs) are among the most widely prescribed agents [1]. For over 30 years, guidelines promote PPIs as the best treatment of gastroesophageal reflux disease (GERD), esophagitis, and peptic ulcer disease [2]. Importantly, PPIs are increasingly prescribed for prolonged, even lifelong, prophylactic use, often without a compelling indication [3]. However, over the last several years there is a growing number of reports associating chronic PPI use with a variety of serious adverse effects [4].

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