Mastocytosis is a heterogeneous, rare disease associated with uncontrolled proliferation, accumulation, and increased survival of mast cells (MCs) in different organs [1]. This pathological condition is related to gain-of-function pathogenic variants of the c-kit gene that encodes for KIT (CD117), a transmembrane tyrosine kinase receptor largely expressed on MC surface [2,3]. These variants lead to autophosphorylation of the KIT receptor causing spontaneous MC proliferation also in absence of the KIT ligand, stem cell factor (SCF) [3,4].
