Published: 4 November 2024
Author(s): Thomas van Sloten, Willem Pieter Brouwer, Jurgen H. Runge, Karel J. van Erpecum
Section: Commentary

Metabolic dysfunction-associated liver disease (MASLD) is the most common chronic liver disease worldwide and a leading cause of liver-related morbidity and mortality, affecting one-third-of the global population. According to a recent meta-analysis, global incidence of MASLD is 4.6 per 100 person years [1]. In the Western world, decompensated cirrhosis and hepatocellular disease due to underlying MASLD have become a major indication for liver transplantation [2]. Also, concomitant MASLD is a risk factor for progressive liver disease in patients with chronic liver disease due to other causes.

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