I read with great interest the paper by Zucchelli et al. [1], which is a cohort study to determine the effect of frailty on mortality in adults aged 60+ without multi-morbidity. Within the first 5 years of follow-up, adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of pre-frail and frail participants for mortality were 2.08 (1.15–3.76) and 2.69 (1.22–5.97), respectively. In contrast, the significance disappeared beyond 5 years, and frailty and pre-frailty were closely related to relatively short-term mortality in older adults free from multi-morbidity.
