The first report of a rise in blood pressure (BP) associated with vaccination for coronavirus disease 2019 (COVID-19) was provided by Meylan et al. [1]. These authors published a series of subjects vaccinated with ‘Comirnaty’ (by Pfizer-BioNtech) or ‘Spikevax’ (by Moderna) [1]. Unexpectedly, hours or days after vaccination, BP in these subjects rose considerably up to levels of 220/115 mmHg [1]. Although subsequent studies substantially confirmed this finding, evidence remains limited [2,3]. The potential basic mechanisms of the BP rise associated with COVID-19 vaccination are elusive, although some possibilities look reasonable.
