Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease compared with the general population [1]. The increased risk of cardiovascular disease in patients with RA is due to the composite effect of genetic predisposition, traditional cardiovascular risk factors, and the presence of chronic oxidative stress [2–4] and systemic pro-inflammatory state. Cardiovascular disease in RA population develops through multiple mechanisms, including accelerated endothelial dysfunction, early arterial stiffening, modifications of central hemodynamics, and premature atherosclerosis [5–7].
