Dealing with patients with multiple chronic conditions (MCC) is certainly one of the most compelling healthcare challenges [1]. Most of the available data about MCC derive from large administrative databases [2] with limited clinical transferability [3], and from the primary care [4,5], with a consequent lack of information in hospitalized patients who represent the distinctive setting of internal medicine [6]. Finally, there are still uncertainties about the clinical usefulness of splitting MCC into either comorbidity, i.e., any additional entity in reference to a single condition under study, or multimorbidity, i.e., the stochastic co-occurrence in the same patient of multiple conditions in which no single one holds priority [7].
