Tuberculosis (TB) can complicate the course of various autoimmune diseases, especially with prolonged use of immunosuppressive treatment [1–9]. Limited data are currently available regarding risk factors for, and clinical presentation of, TB in patients with autoimmune diseases. We performed an observational study of all cases of TB diagnosed during years 1992–2012 within a cohort of patients followed for autoimmune diseases in a 1800-bed university hospital, which serves as a referral center for autoimmune diseases in Western France (population catchment area, one million inhabitants).