Diagnostic tools are essential, expensive, and limited hospital's resources. Inappropriate use of blood tests or diagnostic imaging during the medical investigation compromises dramatically the efficiency of the organization (in terms of costs, utilization of human resources and overload on service providers within the hospital) and quality of care (in terms of the effectiveness of the diagnostic processes and patients' safety). The SMART Medicine initiative dealt with the development and implementation of a defined methodology for judicious use of diagnostic tools, aimed at raising the level of performance of the diagnostic process, neither the clinical part nor the use of diagnostic tools, in terms of quality and efficiency [1].