Adiponectin is a circulating cytokine produced by the adipose tissue. Experimental data suggest that adiponectin exerts beneficial effects on insulin sensitivity, chronic low-grade inflammation, oxidative stress and atherosclerotic process [1]. Paradoxically, the majority of studies that addressed the association of circulating adiponectin levels with cardiovascular (CV) or total mortality, have found a positive, rather than the expected negative, relationship between adiponectin and mortality [2].
