We are glad to share with Corredoira and colleagues the interest for our recently published work regarding the relationship between Enteroccocus spp infective endocarditis (EIE) and colorectal neoplasm (CRN) [1]. In their letter to the Editor, entitled “Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory?” [2], Correidora et al. highlight some of the key clinical features we also deem of utmost importance when approaching a patient with EIE. Indeed, as underscored by our Spanish colleagues, accumulating evidence from several retrospective studies supports the usefulness of colonoscopy not only in Streptococcus gallolyticus endocarditis but also in EIE, irrespective of whether the focus of infection is obvious or unknown [1,2].