Nonvariceal gastrointestinal (GI) bleeding is common and one of the most frequent medical events which determine hospitalizations worldwide. Death rates (5-12%) in patients with GI bleeding are resistant to decrease despite the new advances in diagnosis and therapy, which is probably linked to a higher proportion of elderly patients with significant comorbidities who suffer from this complication [1]. However, the number of hospitalizations due to GI bleeding is decreasing over time in many countries with a sharp reduction of upper GI bleeding events, which is not compensated by the observed increase in the number of hospitalizations due to lower GI bleeding events [2].