The use of cannabis for medical purposes is increasing worldwide [5,32]. With the changing public and political opinion, more countries are implementing medical cannabis legalization. Although approved in many regions, safety data from clinical trials are not as robust for medical cannabis as for other pharmacotherapies. The focus of this piece will be on herbal medical cannabis, not pharmaceutical cannabis-based medicines (e.g. Sativex, Nabilone, Dronabinol), as the safety considerations for herbal cannabis are less clear in the current literature.