Since the beginning of the SARS-CoV-2 pandemic and its disease (COVID-19), over 200 million cases of infection and 4.37 million deaths have been reported world-wide [1,2]. While the most common acute phase symptoms include cough, fatigue, fever, dyspnea, musculoskeletal disorders, gastrointestinal symptoms, anosmia and dysgeusia [3,4], data on Long-COVID, defined as the persistence of symptoms after 12 weeks from hospital discharge [5,6], is limited and its relevance is still unclear. Early reports suggest that as many as 60–80% of patients with critical COVID-19 show symptoms at 1 month from hospital discharge, with fatigue and dyspnea being the most frequent ones [7].
