Acute aortic syndromes (AASs) are diseases involving the thoracic aorta, with variable involvement of the abdominal aorta and the main aortic branches, sharing common etiological, pathophysiological, clinical, and therapeutic features. AASs have unspecific clinical presentations requiring large diagnostic differential, engage organ malperfusion syndromes, inflammation, and coagulation pathways, and require targeted medical treatments with multiorgan monitoring. In the last decade, huge advances in diagnostic and therapeutic strategies have been achieved [1–3].