Human albumin is the most abundant circulating protein and accounts for approximately 50–60% of all total plasma proteins in healthy individuals. The molecule is composed of 585 amino acids organised into three homologous domains (I, II and III), each of which containing two distinct subdomains. The liver is the only site of production, with the hepatocytes entering into the blood circulation about 9–12 gs of albumin every day [1,2]. In physiological conditions, albumin synthesis involve only 20–30% of hepatocytes, therefore there is a large functional reserve allowing to increase it by 3–4 times when needed.
