The coronavirus disease 2019 (COVID-19) pandemic had a tremendous impact on almost all aspects of life. More than 776 million confirmed cases of COVID-19 globally have resulted in 7 million deaths, while million others are dealing with the prolonged aftereffects of the COVID-19 infection (long COVID syndrome) [1]. Different variants have succeeded one another, with eminent variations in transmission and clinical presentation [2], with Delta and Omicron being the dominant ones. The majority of existing data, especially early upon Omicron predominance, associated Omicron with lower severity and risk of unfavorable outcomes (hospitalization, oxygen requirements, admission into intensive care unit (ICU) and death) [3–6].