Pruritic wrinkling of the palmar skin following brief contact with water, aka aquagenic wrinkling of the palms (AW), has been repeatedly described as a clinical manifestation of cystic fibrosis (CF), the most frequent severe autosomal recessive disease in caucasians. AW has been reported also in individuals where a single mutation of the gene responsible for CF (CF Transmembrane Regulator, CFTR) had been detected. A study on a small population reported a 1 in 4 frequency of AW among carriers [1,2], and it has been suggested that this dermatological manifestation is a signal of CF carriership [3].
