Published: 19 August 2019
Author(s): Daniel Shepshelovich, Dafna Yahav, Ariadna Tibau, Eitan Amir
Issue: August 2019
Section: Original Article

Modifications of primary outcome measures after trial initiation can undermine their scientific validity. We aimed to quantify these changes and to characterize potential predictors in clinical drug trials published in high impact factor general medicine journals.

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