Lay summary: Acute pancreatitis (AP) and advanced chronic liver disease are severe and increasingly prevalent disorders with overlapping risk factors. We demonstrate for the first time that the presence of liver cirrhosis (LC) constitutes a major risk factor for adverse outcomes of AP, and that cirrhosis patients with AP (LC-AP) are at high risk for infections, periprocedural complications and death. We also demonstrate that common AP scoring systems fail to identify LC-AP patients at risk, and that portal hypertension and liver disease severity are the main determinants of patient outcomes.
