August 2022

105 Articles

No Section

Angiographic and clinical outcome of SARS-CoV-2 positive patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: a collaborative, individual patient data meta-analysis of six registry-based studies

17 August 2022
Author(s): Giuseppe De Luca, Angelo Silverio, Monica Verdoia, Zbigniew Siudak, Tomasz Tokarek, Thomas A. Kite, Anthony H. Gershlick, Oriol Rodriguez-Leor, Belen Cid-Alvarez, Daniel A. Jones, Krishnaraj S. Rathod, José M Montero-Cabezas, Alfonso Jurado-Roman, Matteo Nardin, Gennaro Galasso

Coronavirus disease 2019 (COVID-19) has strongly impacted on worldwide healthcare systems with significant resources diverted to deal with this unforeseeable modern pandemic. Several reports have... more

Validation of anti-neutrophil cytoplasm antibodies associated vasculitides diagnosis codes from the electronic health records of two French university hospitals

18 May 2022
Author(s): Camille Mettler, Samir Bouam, Sandra Liva-Yonnet, Gregory Pugnet, Benjamin Terrier

ANCA-associated vasculitides (AAV) are necrotizing vasculitis, with few or no immune deposit, predominantly affecting small vessels. Among AAV, granulomatosis with polyangiitis (GPA) is characterized... more

Clinical Insights

Structural evolution of severe acute respiratory syndrome coronavirus 2: Implications for adhesivity to angiotensin-converting enzyme 2 receptors and vaccines

11 August 2022
Author(s): Martina Zappa, Paolo Verdecchia, Antonio Spanevello, Fabio Angeli

The Omicron BA.5 variant currently accounts for the majority of cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection ( more


Ultrafiltration in decompensated heart failure: Is time to look forward?

16 August 2022
Author(s): Gianfranco Sinagra, Enrico Fabris

Heart failure (HF) is a chronic condition resulting in more than 1 million hospitalizations annually in both the United States and Europe [1]. Because the natural history of HF is characterised by... more

Assessment of cardiovascular risk with C-reactive protein in rheumatoid arthritis patients

13 August 2022
Author(s): Rita Queirós, Fernando Salvador

Over the past decades, it has become increasingly accepted that the risk of cardiovascular (CV) morbidity and mortality is noticeably augmented in rheumatoid arthritis (RA) patients [1]. When... more

Not all the eggs and the chickens are the same: The case of uric acid and metabolic syndrome

20 July 2022
Author(s): Claudio Borghi, Federica Fogacci, Federica Piani

Uric acid represents the end-product of purine metabolism in humans and the great apes where it has played some evolutive roles over the time [1]. The production of uric acid is largely regulated by... more

Renin-angiotensin-aldosterone inhibition in chronic heart failure: From theory into practice

1 July 2022
Author(s): Raúl Ramos, Pedro Moliner, Josep Comin-Colet

Heart failure (HF) is an extremely relevant chronic disease impacting on quality of life and prognosis. Furthermore, the increasing prevalence of HF leads to a huge number of admissions and entails... more

The case of diabetes mellitus and atrial fibrillation: Underlining the importance of non-cardiovascular comorbidities

27 June 2022
Author(s): Marco Proietti, Giulio Francesco Romiti, Stefania Basili

In the currently changing scenario, in which our patients are progressively older and more likely burdened by concomitant chronic long-term conditions [1], diabetes mellitus (DM) play a prominent... more

High risk of complications and mortality in cirrhotic patients with acute pancreatitis

17 June 2022
Author(s): Karel J. van Erpecum, Paul Didden, Robert C. Verdonk

Acute pancreatitis is one of the most common gastrointestinal diseases requiring acute hospital admission. Gallstones (50%) and alcohol (20%) are the most frequent underlying causes. Medication,... more

Lights and shadows on JAK inhibitors for Ankylosing Spondylitis

20 May 2022
Author(s): Giovanni Benanti, Lorenzo Dagna, Corrado Campochiaro

Ankylosing Spondylitis (AS) is an autoimmune disease characterized by inflammation of the spine and sacroiliac joints, historically described in young males with progressive structural damage of the... more

Ideas and Opinions

Participants’ informed consent in adaptive, platform drug trials in hospitalized COVID-19 patients: Not all approaches are ethically acceptable

27 June 2022
Author(s): Rafael Dal-Ré, Arthur L Caplan, Teck Chuan Voo

One of the most exciting bits of news that the COVID-19 pandemic has provided in the clinical research arena is demonstrating that adaptive, platform randomized controlled trials (ad-RCTs) provided... more

Internal Medicine Flashcard

A « tipical » but rare cause of neck pain

16 August 2022
Author(s): Quentin Richier, Jean-Yves Travers, Loïc Raffray

A 34-year-old man with medical history of familial deafness presented to the emergency department for an acute left cervicalgia and painful jaw for one week. He reported a context of recent physical... more

Not always “straight ahead” – A surprising cause of acute kidney injury

16 August 2022
Author(s): Meidad Greenberg, Alon Bnaya, Keren Cohen-Hagai

A 16-year-old girl presented with a complaint of vomiting and abdominal pain, which appreared immediately following hair straightening treatment. Her medical history was remarkable for untreated... more

Dorsal pigmentation of tongue

12 August 2022
Author(s): Takeshi Onda, Kamichika Hayashi, Masayuki Takano

A 56-year-old male patient with diabetes presented with black discolouration of the tongue 7 days after extraction of two mandibular molars (Fig. 1). Prophylactic oral amoxicillin 750 mg was started... more

A red herring electrocardiogram

12 August 2022
Author(s): Anish Kapil

A gentleman in his 50s presented with atypical chest pain for the last 3 months. He had no prior comorbidities. Cardiovascular system examination was unremarkable. Baseline electrocardiogram is shown... more

“Milking” the way to diagnosis

11 August 2022
Author(s): Andreína Vasconcelos, Bárbara Rodrigues, Pedro Gonçalo Ferreira

A 43-year-old non-smoker man presented to the emergency department with exertional dyspnoea and left pleuritic pain lasting for 3 days. He denied fever and cough and described a history of pulmonary... more

Generalized erythematous scaly rash after glucocorticoids

10 August 2022
Author(s): Miguel Sogbe, Andrés Blanco-Di Matteo, José Luis Del Pozo

A 65-years-old woman with a medical history of idiopathic thrombocytopenic purpura and psoriasis in treatment with topical glucocorticoids presented with a three-month history of burning, generalized... more

Interstitial pneumonia with subpleural sparing and weight loss

13 July 2022
Author(s): Federico Vanoni, Andrea Caccioppo, Fabrizio Elia

A 36-years-old man from West Africa was admitted to our ED with respiratory failure and a 15 days history of fatigue and peevish cough. He reported watery diarrhea and a 30 kg weight loss in the last... more

Malar rash with pancytopenia

4 July 2022
Author(s): Hiroshi Hori, Takahiko Fukuchi, Hitoshi Sugawara

A 35-year-old Japanese man presented with a four-month history of persistent flushing and persistent high fever (≥38 °C) for the past several weeks.

The hardest pill to swallow: A freak of nature

29 June 2022
Author(s): Eloy F. Ruiz, Muhammad Ahsan, Mehak M. Laharwal

Not required

A diabetic patient with finger gangrene

20 May 2022
Author(s): Sho Osonoi, Kiho Hamaura, Hiroshi Murakami

A 72-year-old male with type 2 diabetes and end-stage renal disease (ESRD) receiving hemodialysis (HD) for 10 months presented to hospital with one week of worsening pain, swelling, and bluish-black... more

Necrotic ulcers in an immunocompromised patient

19 May 2022
Author(s): Wan Syazween Lyana Wan Ahmad Kammal, Nur Shairah Mohamad Fazial, Adawiyah Jamil

A 68-year-old man presented to dermatology clinic with extensive ulcers for one-week duration. Patient had underlying uncontrolled Type II Diabetes Mellitus and pemphigus foliaceous. His medications... more

An unusual cause of severe watery diarrhea

16 May 2022
Author(s): Yusaku Kajihara

A 75-year-old man presented to the gastroenterology department with a 4-week history of severe watery diarrhea (at least 20 times a day) and appetite loss. He had been taking amlodipine 5 mg once... more

A HIV-positive subject with dermatomal and generalized vesicular skin lesions

13 May 2022
Author(s): Andrea Poloni, Maria Vittoria Cossu, Spinello Antinori

A 58-year old man with HIV infection diagnosed in 2018 presented in July 2021 with a 7-day history of vesicular skin lesions localized to the right side of abdomen and diffuse vesicular lesions on... more

Skin rash following amoxicillin treatment

13 May 2022
Author(s): Yuya Ando, Satoko Senda, Yosuke Ono

A 26-year-old woman presented with a chief complaint of nausea for 2 days. On the previous day, she had been diagnosed with tonsilitis by her previous doctor because of fever and sore throat, and had... more

Letter to the Editor

Publication and citation inequalities faced by African researchers

17 August 2022
Author(s): Paul Sebo

The study of discrimination in research focused primarily on gender inequalities [1,2], and programs were launched in many countries to increase representation of women in key-positions and improve... more

Is the benefit of sodium-glucose cotransporter inhibitors over heart failure progression on the kidney side?

16 August 2022
Author(s): Edoardo Gronda, Massimo Iacoviello, Domenico Gabrielli, Pasquale Caldarola, Luigi Tavazzi, CArdiac REnal MEtabolic (CARE ME) Scientific Area, Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO)

Dear Editor,

Gastrointestinal adverse events of semaglutide in patients with overweight or obesity

16 August 2022
Author(s): Muhammad Ali Tariq, Hamza Amin, Qazi Shurjeel, Ahmed Gang, Ashar Mohiuddin

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) and is a well-established, safe, and effective treatment for type 2 diabetes mellitus (T2DM) with favorable effects on glycemic... more

A Reappraisal of Corticosteroids use for COVID-19

15 August 2022
Author(s): Ilaria Pati, Francesca Masiello, Simonetta Pupella, Mario Cruciani, Vincenzo De Angelis

The current evidence suggests that the rapid clinical progression of the Coronavirus Disease 2019 (COVID-19) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is... more

Inhaled triple therapy in individuals with Chronic Obstructive Pulmonary Disease and indications of pulmonary rehabilitation

15 August 2022
Author(s): Michele Vitacca, Mara Paneroni, Antonio Spanevello, Piero Ceriana, Nicolino Ambrosino

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease, characterized by persistent and progressive airflow limitation, worsening reduced exercise capacity, and health-... more

Knowing the new Omicron BA.2.75 variant (‘Centaurus’): A simulation study

15 August 2022
Author(s): Martina Zappa, Paolo Verdecchia, Fabio Angeli

Dear Editor,

Pitfalls for blood culture diagnostic stewardship

1 August 2022
Author(s): Hiroshi Ito

According to Dräger S and colleagues [1], about half of the blood culture tests were not indicated according to the guidelines in a Swiss university hospital. They concluded that implementing a... more

Influenza vaccine among patients with coronary artery disease

1 August 2022
Author(s): Hamed Mohamed, Al-Azizi Karim, Jneid Hani, Khalife Wissam, Elbadawi Ayman, on behalf of INFCAD

Infection has been proposed to be a possible risk factor for the process of atherosclerosis [1]. Influenza virus infection has been temporally associated with cardiovascular morbidity and mortality,... more

Alzheimer's disease and increasing the uptake of influenza vaccination

29 July 2022
Author(s): Ami Schattner

Despite unequivocal research and guidelines, the uptake of influenza vaccination remains markedly suboptimal even among older adults whose risk of substantial influenza-associated morbidity and... more

Serum cystatin C, cystatin C level change and risk of atrial fibrillation

20 July 2022
Author(s): Odong Christopher, Yiquan Huang, Zhenyu Xiong, Xiaodong Zhuang, Xinxue Liao

Dear Editor,

Gadolinium deposition disease (GDD): Does the missing link exist? -A suggested pathologic model

18 July 2022
Author(s): Ingrid B. Boehm

Initially, gadolinium-based contrast agents (GBCAs) have been considered as inert compounds without any potential to induce adverse side effects. Now, more than three decades after their introduction... more

COVID-19 mRNA vaccination in patients with previous myocarditis

17 July 2022
Author(s): Maurizio Pieroni, Michele Ciabatti, Elisa Saletti, Emanuele D'Aniello, Leonardo Bolognese, on-behalf-of-the-COVID-Vaccine-in-myocarditis-study-group

Dear Editor,

Causal effect of non-alcoholic fatty liver disease on atrial fibrillation

15 July 2022
Author(s): Jun Chen, Ziwei Mei, Yimin Wang, Yijie Chen, Qiang Liu

Non-alcoholic fatty liver disease (NAFLD) includes a range of liver pathologies based on non-alcoholic fatty liver, defined by the presence of fat accumulation in more than 5% of hepatocytes by non-... more

Janus kinase inhibitors in patients with ankylosing spondylitis: Great news, but some concerns on cardiovascular disease risk still exist. Author's reply

12 July 2022
Author(s): Shu Li, Fen Li, Ni Mao, Jia Wang, Xi Xie

We appreciate the opportunity to reply to the Letter to the Editor by Dimosiari and colleagues [1], commenting on our work [2]. We concur with them that the cardiovascular disease (CVD) risk of Janus... more

Association of tenofovir and entecavir use with prognosis after surgical resection for hepatitis B virus-related hepatocellular carcinoma

11 July 2022
Author(s): Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin-Ha Yoon, Beom Kyung Kim

Potent antiviral therapy (AVT) against hepatitis B virus (HBV) can induce regression of liver fibrosis, thereby reducing the development of liver cirrhosis and hepatocellular carcinoma (HCC) [1]. A... more

Ultrasound assessment of splanchnic circulation in Systemic Sclerosis: a non-invasive approach for the study of bowel vasculopathy?

9 July 2022
Author(s): Giulia Bandini, Esterita Accogli, Laura Cometi, Marco Matucci-Cerinic, Alberto Moggi Pignone

Dear editor,

The impact of co-working with an Internist in a high-speciality division of cardiology in a third-level centre. Experience with a new organization model

5 July 2022
Author(s): Valentina Scheggi, Lorenzo Righi, Guia Moschi, Maria Teresa Mechi, Niccolò Marchionni

Despite remarkable international differences, most European health care systems rely on a primary care, a secondary care and more specialized or tertiary institutions, which often focus mainly on one... more

Olmesartan-induced enteropathy: More than one entity?

4 July 2022
Author(s): Giuseppe Famularo, Andrea Aglitti, Laura Magrini

Dear Editor,

Sodium-glucose cotransporter 2 inhibitors reduce cardiovascular events in acute heart failure. A real-world analysis

27 June 2022
Author(s): Raquel López-Vilella, Víctor Donoso Trenado, Borja Guerrero Cervera, Ignacio Sánchez-Lázaro, Luis Almenar Bonet

Since the recent past, sodium-glucose cotransporter type 2 inhibitors (SGLT2i) have been recommended as mainstay therapy for patients with chronic heart failure (HF) and reduced ejection fraction (... more

Serum and urine angiopoietin-like protein 4 levels correlate with different degrees of dislipidemea and proteinuria in patients with primary nephrotic syndrome

24 June 2022
Author(s): Yue Li, Huajie Liu, Jingzhi Wang, Wangqiu Gong, Xia Gao

Primary nephrotic syndrome (PNS) is characterized by massive proteinuria, hypoproteinemia, edema and hyperlipidemia. Angiopoietin like protein 4 (ANGPTL4) is a secretory glycoprotein and belongs to... more

Supine vs prone position in mild to moderate COVID-19 pneumonia: The impact of proning on computed tomography findings

16 June 2022
Author(s): S Piciucchi, ML Garo, S Tomassetti, C Ravaglia, V Poletti

Dear Editor,

Blood pressure increase during hospitalization for COVID-19

15 June 2022
Author(s): Fabio Angeli, Martina Zappa, Federico Mattia Oliva, Antonio Spanevello, Paolo Verdecchia

The first report of a rise in blood pressure (BP) associated with vaccination for coronavirus disease 2019 (COVID-19) was provided by Meylan et al. [1]. These authors published a series of subjects... more

Effects of statins on clinical outcomes in hospitalized patients with COVID-19

8 June 2022
Author(s): Paulo Ricardo Martins-Filho, José Augusto Soares Barreto-Filho, Antônio Carlos Sobral Sousa

Statins are lipid-lowering drugs that have been evaluated as a potential treatment for COVID-19 due to their pleiotropic effects, including anti-inflammatory, immunomodulatory, antioxidant,... more

Trends of thrombo-inflammation biomarkers after Tocilizumab predict treatment failure better than scores in patients with severe SARS-CoV2 related respiratory failure

5 June 2022
Author(s): Luca Masotti, Elisa Cioni, Elisa Grifoni, Francesco Cei, Roberto Tarquini

Cytokine antagonists are now concrete therapeutic options in patients with severe SARS-CoV2 respiratory failure. The Interleukin-6 (IL-6) inhibitor tocilizumab (TCZ) has shown to significantly reduce... more

Janus kinase inhibitors in patients with ankylosing spondylitis: Great news, but some concerns on cardiovascular disease risk still exist

3 June 2022
Author(s): Athina Dimosiari, Theodoros Michailidis, Dimitrios Patoulias

We have read with great interest the results of the meta-analysis conducted by Li and colleagues [1], demonstrating that Janus kinase (JAK) inhibitors are a safe treatment option for patients with... more

Systemic diseases associated with a diagnosis of achalasia: A case-control study with the All of Us research program

1 June 2022
Author(s): Erik Almazan, Gayane Yenokyan, Kenneth Ng

Esophageal achalasia is an idiopathic disorder characterized by degeneration of neurons in the myenteric plexus of the esophagus [1]. Enteric neuropathies, primary and secondary, have been proposed... more

Ten year anniversary of choosing wisely campaigns

31 May 2022
Author(s): Omar Kherad, Antonio Vaz Carneiro, Choosing Wisely Working Group of the European Federation of Internal Medicine

We read with interest the perspective letter “Ten Years of Choosing Wisely to Reduce Low-Value Care” by Elizabeth J. Rourke [1]. As campaign leaders and members of the Choosing Wisely (CW) working... more

Syndrome of inappropriate antidiuresis as a maladaptive stress response shared by coronavirus disease 2019 and other cytokine storm disorders

30 May 2022
Author(s): Lorenzo Muccioli, Umberto Pensato, Maria Guarino, Francesca Bisulli, Marco Faustini Fustini

Dear Editor,

The Omicron wave and the waning of COVID-19 vaccine effectiveness. Influence of vaccine booster and age on confirmed infection incidence

26 May 2022
Author(s): Luis Corral-Gudino, María Piedad Del-Amo-Merino, José María Eiros-Bouza, Jesús Fernando García-Cruces-Méndez, Marta Domínguez-Gil González

Dear Editor,

Personal protective equipment portraits in the era of COVID-19

26 May 2022
Author(s): Christopher Hansen-Barkun, Omar Kherad, Adamo A Donovan, Anupa J Prashad, Maida J Sewitch

Use of personal protective equipment (PPE) aims to prevent SARS CoV-2 transmission in the healthcare setting. However, PPE limits human connection and non-verbal communication by masking individuals... more

Efficacy and safety of molnupiravir for COVID-19 patients

25 May 2022
Author(s): Maurish Fatima, Saleha Azeem, Junaid Saeed, Abia Shahid, Huzaifa Ahmad Cheema, COVID-19 Therapeutics Study Group

Dear Editor,

Disease phenotype and outcomes of very early-onset inflammatory bowel disease

6 May 2022
Author(s): Valeria Dipasquale, Giovanna Lo Presti, Claudio Romano

Dear Editor,

Risk factors for chronic thromboemboli after pulmonary thromboembolism

22 April 2022
Author(s): N Leal, A Freitas, F Leal, J Pimenta, T Gregório

Pulmonary thromboembolism is the third leading cause of cardiovascular death, after coronary artery disease and stroke [1].

General practitioner agreement and adherence to the Swiss Choosing wisely top 5 list: A cross-sectional survey

21 April 2022
Author(s): Mae Cuérel, Marc-André Raetzo, Kevin Selby, Omar Kherad

Choosing Wisely (CW) campaigns have spread around the world to stimulate conversations between physicians and patients about unnecessary tests, treatments, and procedures that account for up to 20%... more

Serum-ascites albumin gradient – A false dichotomy in the approach to ascites

15 April 2022
Author(s): Isaac Núñez, Fernando Solis-Huerta, Adrian Soto-Mota

Ascites is a clinical scenario frequently encountered in primary care, internal medicine and gastroenterology. Formal guidelines on its approach and management exist and recommend measuring the serum... more

Experience with procalcitonin use during the COVID-19 pandemic

13 April 2022
Author(s): Laura Gonzalez, Thomas Holman, Daniel Wait, Pearl Abenojar

Procalcitonin (PCT) is a protein precursor of calcitonin that has been proposed to differentiate systemic inflammation of bacterial origin from viral. The lack of rise in viral infections may be due... more

Hospitalized patients are needlessly over-tested for heparin induced thrombocytopenia

11 April 2022
Author(s): Udhayvir Singh Grewal, Shiva Jashwanth Gaddam, Sahith Reddy Thotamgari, Tyiesha Brown, Kavitha Beedupalli, Glenn Morris Mills

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Patients with HIT present with a decline... more

Original Article

Screening for atrial fibrillation in the elderly: A network meta-analysis of randomized trials

8 August 2022
Author(s): Ayman Elbadawi, Ramy Sedhom, Mohamed Gad, Mohamed Hamed, Amr Elwagdy, Amr F. Barakat, Umair Khalid, Mamas A. Mamas, Yochai Birnbaum, Islam Y. Elgendy, Hani Jneid

Atrial fibrillation (AF) is a prevalent and common treatable risk factor for ischemic stroke [1]. The prevalence of AF increases with aging. It has been estimated that the lifetime risk of AF is 1 in... more

Incidence, risk factors, and evolution of venous thromboembolic events in patients diagnosed with pancreatic carcinoma and treated with chemotherapy on an outpatient basis

2 August 2022
Author(s): Silvia García Adrián, Adán Rodríguez González, Eva Martínez de Castro, Vanessa Pachón Olmos, Laura Ortega Morán, Purificación Martínez del Prado, Mercedes Salgado Fernández, José David Cumplido Burón, Ignacio García Escobar, Joaquina Martínez Galán, Ana Isabel Ferrer Pérez, Fernando Neria, Diego Cacho Lavin, Borja López de San Vicente Hernández, Paula Jiménez-Fonseca, Andrés J. Muñoz Martín

Venous thromboembolic disease is considered one of the leading causes of morbi-mortality [1,2]. in oncological patients. Cancer multiplies the risk of thromboembolic events 6- or 7-fold compared to... more

Varicella-Zoster virus reactivation following severe acute respiratory syndrome coronavirus 2 vaccination or infection: New insights

31 July 2022
Author(s): Raquel Martinez-Reviejo, Sofia Tejada, Ganiyat A.R. Adebanjo, Camilla Chello, Miriam C. Machado, Francesca R. Parisella, Magda Campins, Antonella Tammaro, Jordi Rello

Coronavirus disease-2019 (COVID-19) is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1]. The systemic manifestations of COVID-19 comprise respiratory,... more

A machine learning approach to characterize patients with asthma exacerbation attending an acute care setting

31 July 2022
Author(s): Maria D'Amato, Pasquale Ambrosino, Francesca Simioli, Sarah Adamo, Anna Agnese Stanziola, Giovanni D'Addio, Antonio Molino, Mauro Maniscalco

Asthma is a respiratory disease with a wide spectrum of clinical presentations. The prevalence in adults is 8.2% and 9.4% in children in the European Union [1]. Severe asthma is a clinical condition... more

Host response dysregulations amongst adults hospitalized by influenza A H1N1 virus pneumonia: A prospective multicenter cohort study

30 July 2022
Author(s): Blanca Valenzuela-Méndez, Francisco Valenzuela-Sánchez, Juan Francisco Rodríguez-Gutiérrez, Rafael Bohollo-de-Austria, Ángel Estella, Pilar Martínez-García, María Ángela González-García, Grant Waterer, Jordi Rello

The influenza virus affects the respiratory tract through direct damage, or indirectly through the inflammatory response. While the inflammatory and immune response produced after influenza infection... more

Nutritional status in patients with hepatocellular carcinoma: Potential relevance for clinical outcome

26 July 2022
Author(s): Anne M. van Dijk, Bart J.P. Coppens, Maartje A. van Beers, Alexandra S. Bruins Slot, Carina J.R. Verstraete, Joep de Bruijne, Frank P. Vleggaar, Karel J. van Erpecum


Different profiles of advanced heart failure among patients with and without diabetes mellitus. Findings from the EPICTER study

22 July 2022
Author(s): José Carlos Arévalo Lorido, Juana Carretero Gómez, Miriam Romero Correa, Jesus Recio Iglesias, Teresa Choucino Fernández, Rosa Jordana Camajuncosa, Margarita Carrera Izquierdo, Carlos Jiménez Guardiola, Lucía Fuentes Pardo, Esther Piniella Ruiz, Francesc Formiga, Prado Salamanca Bautista

Heart failure (HF), the representative end-stage of most heart diseases, has a heterogeneous course that makes it difficult to know with certainty whether a patient is in the advanced stage of the... more

Autoantibody positivity predicts severity of rheumatic immune-related adverse events to immune-checkpoint inhibitors

9 July 2022
Author(s): Corrado Campochiaro, Nicola Farina, Alessandro Tomelleri, Roberto Ferrara, Silvia Viola, Chiara Lazzari, Giacomo De Luca, Daniele Raggi, Alessandra Bulotta, Marco Matucci-Cerinic, Andrea Necchi, Marina Garassino, Vanesa Gregorc, Lorenzo Dagna

In the last decade, immune checkpoint inhibitors (ICIs) have become a therapeutic tool of paramount importance when managing malignancies. ICIs currently represent the standard of care for several... more

C-reactive protein and 10-year cardiovascular risk in rheumatoid arthritis

9 July 2022
Author(s): Gian Luca Erre, Fabio Cacciapaglia, Garifallia Sakellariou, Andreina Manfredi, Elena Bartoloni, Ombretta Viapiana, Marco Fornaro, Alberto Cauli, Arduino Aleksander Mangoni, Richard John Woodman, Bianca Lucia Palermo, Elisa Gremese, Giacomo Cafaro, Valeria Nucera, Caterina Vacchi, Francesca Romana Spinelli, Fabiola Atzeni, Matteo Piga, “Cardiovascular, Obesity and Rheumatic Disease Study (CORDIS) Group” of the Italian Society of Rheumatology (SIR)

Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease compared with the general population [1]. The increased risk of cardiovascular disease in patients with RA is... more

Epidemiology of subclinical atrial fibrillation in patients with cardiac implantable electronic devices: A systematic review and meta-regression

8 July 2022
Author(s): Marco Proietti, Giulio Francesco Romiti, Marco Vitolo, Marco Borgi, Arianna Di Rocco, Alessio Farcomeni, Kazuo Miyazawa, Jeff S Healey, Deirdre A Lane, Giuseppe Boriani, Stefania Basili, Gregory Y.H. Lip

In 1958 Senning and Elmqvist implanted the first permanent cardiac pacemaker (PM) to Arne Larsson, who survived for more than 40 years and ultimately died from different causes [1]. Since then, the... more

IgA nephropathy with acute kidney disease: Characteristics, prognosis, and causes

28 June 2022
Author(s): Xutong Wang, Zuishuang Guo, Bo Huang, Minhua Xie, Jingjing Ren, Yuze Zhu, Haonan Guo, Yongli Wang, Dan Yu, Junjun Zhang, Linqi Zhang

The clinical manifestations and prognosis of IgA nephropathy (IgAN) are diverse. Some patients may present with kidney dysfunction lasting shorter than 3 months and meet the acute kidney disease (AKD... more

Nebivolol protects erectile functions compared to Metoprolol in hypertensive men with atherogenic, venogenic, psychogenic erectile dysfunction: A prospective, randomized, cross-over, clinical trial

23 June 2022
Author(s): Gokhan Gungor, Hakki Perk, Sedat Soyupek, Bahattin Baykal, Murat Demir, Mehmet Tugrul Sezer

Erectile dysfunction (ED) is defined as the inability to achieve or maintain a sufficient erection to engage in sexual intercourse [1]. Erectile functions are related to the quality of life of... more

Durable functional limitation in patients with coronavirus disease-2019 admitted to intensive care and the effect of intermediate-dose vs standard-dose anticoagulation on functional outcomes

19 June 2022

Coronavirus disease-2019 (COVID-19) has post-acute manifestations that may impact the everyday life functional and the mental health status of the affected patients [1]. In a cross-sectional global... more

Physician care access plays a significant role in extending global and regional life expectancy

14 June 2022
Author(s): Wenpeng You, Frank Donnelly

Life expectancy is a statistical measure for the average number of years a person in a population could expect to live based on current age and sex-specific death rates [1]. It has been the most... more

Do we need blood culture stewardship programs? A quality control study and survey to assess the appropriateness of blood culture collection and the knowledge and attitudes among physicians in Swiss hospitals

14 June 2022
Author(s): Sarah Dräger, Céline Giehl, Kirstine Kobberøe Søgaard, Adrian Egli, Mirjam de Roche, Lars C. Huber, Michael Osthoff

As bloodstream infections (BSI) are associated with a mortality of 14% and up to 35% in critically ill patients, physicians often have a low threshold to collect blood cultures (BC) [1–3]. But... more

External validation of risk scores to predict in-hospital mortality in patients hospitalized due to coronavirus disease 2019

7 June 2022
Author(s): Shermarke Hassan, Chava L. Ramspek, Barbara Ferrari, Merel van Diepen, Raffaella Rossio, Rachel Knevel, Vincenzo la Mura, Andrea Artoni, Ida Martinelli, Alessandra Bandera, Alessandro Nobili, Andrea Gori, Francesco Blasi, Ciro Canetta, Nicola Montano, Frits R. Rosendaal, Flora Peyvandi, LUMC‐COVID‐19 Research Group, COVID-19 Network working group

The coronavirus disease 2019 (COVID-19) epidemic, which started in early December 2019, presents an important threat to global health. As of October 18th 2021, the number of patients confirmed to... more

Clinical characteristics of BRASH syndrome: Systematic scoping review

5 June 2022
Author(s): Parthav Shah, Maan Gozun, Koichi Keitoku, Nobuhiko Kimura, Jihun Yeo, Torrey Czech, Yoshito Nishimura

Bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia (BRASH) syndrome is a recently-established entity precipitated by medication-induced AV nodal blockade.... more

High risk of complications and acute-on-chronic liver failure in cirrhosis patients with acute pancreatitis

4 June 2022
Author(s): Michael Vogel, Hanno Ehlken, Stefan Kluge, Thomas Roesch, Ansgar W. Lohse, Samuel Huber, Martina Sterneck, Peter Huebener

Lay summary: Acute pancreatitis (AP) and advanced chronic liver disease are severe and increasingly prevalent disorders with overlapping risk factors. We demonstrate for the first time that the... more

T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patients

2 June 2022
Author(s): Maxime Samson, Barbara Nicolas, Marion Ciudad, Hélène Greigert, Alexandre Guilhem, Claudie Cladiere, Cécile Straub, Mathieu Blot, Lionel Piroth, Thomas Rogier, Hervé Devilliers, Patrick Manckoundia, Thibault Ghesquiere, Stéphanie Francois, Daniela Lakomy, Sylvain Audia, Bernard Bonnotte

Assessment of Th17 cells could help target patients in need of anti-IL6R therapy.

Safety and efficacy of ultrafiltration versus diuretics in patients with decompensated heart failure: A systematic review and meta-analysis

27 May 2022
Author(s): Waqas Ullah, Muhammad Khawar Sana, Hamza Usman Mustafa, Harigopal Sandhyavenu, Alexander Hajduczok, Tanveer Mir, David L. Fischman, Mahek Shah, Yevgeniy Brailovsky, Indranee N. Rajapreyar

Acute decompensated heart failure, a constellation of dyspnea, edema, and fatigue due to volume overload, accounts for the high healthcare costs, projected to increase from $21 billion in 2012 to $70... more

Diagnostic approaches to syncope in Internal Medicine Departments and their effect on mortality

20 May 2022
Author(s): Ehud Galron, Orli Kehat, Ahuva Weiss-Meilik, Raffaello Furlan, Giris Jacob

Syncope is defined as a transient loss of consciousness (TLOC) due to cerebral hypoperfusion, characterized by a rapid onset, short duration, and spontaneous complete recovery [1]. The main... more

Impact of cardiac amyloidosis on outcomes of patients hospitalized with heart failure

16 May 2022
Author(s): Sebastian Göbel, Lukas Hobohm, Alexander Desuki, Tommaso Gori, Thomas Münzel, Rapezzi Claudio, Philip Wenzel, Karsten Keller

Amyloidosis is a multi-systemic disease resulting from deposition of misfolded proteins as insoluble fibrils in the interstitium of affected organs, subsequently leading to organ failure. Cardiac... more

Developing a simple and practical decision model to predict the risk of incident type 2 diabetes among the general population: The Study

12 May 2022
Author(s): Sergio Martínez-Hervás, María M. Morales-Suarez-Varela, Irene Andrés-Blasco, Francisco Lara-Hernández, Isabel Peraita-Costa, José T. Real, Ana-Bárbara García-García, F. Javier Chaves

The prevalence and incidence of type 2 diabetes mellitus (T2DM) are increasing worldwide, and an estimated 50% of patients remain unaware of their disease [1]. T2DM is a highly prevalent chronic... more

Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

5 May 2022
Author(s): Wern Yew Ding, Agnieszka Kotalczyk, Giuseppe Boriani, Francisco Marin, Carina Blomström-Lundqvist, Tatjana S. Potpara, Laurent Fauchier, Gregory.Y.H. Lip, ESC-EHRA EORP-AF Long-Term General Registry Investigators

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, frequently associated with other conditions such as diabetes mellitus [1,2], and confers major healthcare costs [3]. Given... more

Atrial cardiomyopathy markers and new-onset atrial fibrillation risk in patients with acute myocardial infarction

2 May 2022
Author(s): Zhitong Li, Quanbo Liu, Fei Liu, Tesfaldet H. Hidru, Yiheng Yang, Shihao Wang, Lan Bai, Jing Chen, Xiaolei Yang, Yunlong Xia

Acute myocardial infarction (AMI) remains one of the leading causes of mortality globally, new-onset AF (NOAF) after AMI is a common complication of AMI, with an incidence of 6% to 21% [1], which is... more

Efficacy and safety of Janus kinase inhibitors in patients with ankylosing spondylitis: A systematic review and meta-analysis

20 April 2022
Author(s): Shu Li, Fen Li, Ni Mao, Jia Wang, Xi Xie

Ankylosing spondylitis (AS), also known as radiographic axial spondyloarthritis, is the advanced disease stage of axial spondyloarthritis (axSpA) [1]. It was characterized by enthesitis involving the... more

Review Article

Identification and management of acute alcohol intoxication

16 August 2022
Author(s): Antonio Mirijello, Luisa Sestito, Mariangela Antonelli, Antonio Gasbarrini, Giovanni Addolorato

Alcohol is the oldest and most common psychoactive and addictive substance used in our society: it has been estimated that about 90% of people consume alcohol at some stage in their lives and up to... more

Potential mechanisms of vaccine-induced thrombosis

8 August 2022
Author(s): Marco Marietta, Valeria Coluccio, Mario Luppi

COVID-19 has so deeply impacted in every aspect of the human existence that most of us in the next years will reconsider its life as “before” and “after” the pandemic. At the time of writing, more... more

POCUS in dyspnea, nontraumatic hypotension, and shock; a systematic review of existing evidence

1 August 2022
Author(s): Bram Kok, David Wolthuis, Frank Bosch, Hans van der Hoeven, Michiel Blans

Point-of-care ultrasound (POCUS) is defined as the integration of ultrasound imaging into the physical examination by the treating physician. It has shown to speed up the diagnostic process, and to... more

Mycobacterium marinum: A brief update for clinical purposes

19 July 2022
Author(s): Diana Canetti, Niccolò Riccardi, Roberta Maria Antonello, Silvia Nozza, Giovanni Sotgiu

Incident cases of non-tuberculous mycobacteria (NTM) are steadily increasing worldwide [1]. Among NTM, Mycobacterium marinum (M. marinum) is one of the causes of extrapulmonary mycobacterial... more

The COVID-19 pandemic – How many times were we warned before?

17 July 2022
Author(s): Naim Mahroum, Isa Seida, Sevval Nil Esirgün, Nicola Luigi Bragazzi

As the pandemic of coronavirus disease 2019 (COVID-19) continues to emerge worldwide with no country being spared [1], scientists and researchers are relentlessly looking for the origin of SARS-CoV-2... more

COVID-19, vaccines and deficiency of ACE2 and other angiotensinases. Closing the loop on the "Spike effect"

21 June 2022
Author(s): Fabio Angeli, Gianpaolo Reboldi, Monica Trapasso, Martina Zappa, Antonio Spanevello, Paolo Verdecchia

The role of a dysregulated renin-angiotensin system (RAS) in the pathogenesis of COVID-19 is well recognized. The imbalance between angiotensin II (Ang II) and Angiotensin1-7 (Ang1,7) caused by the... more

Sudden death in young athletes: Is it preventable?

17 June 2022
Author(s): Pietro Amedeo Modesti, Giancarlo Casolo, Iacopo Olivotto, Alessio Pellegrino

Sudden deaths in athletes (SDA) are rare but devastating events, with huge social impact and vast echo in the media. Elite athletes are contemporary icons epitomizing health and success, promoting... more

Adult-onset type 1 diabetes: A changing perspective

16 June 2022
Author(s): J Burahmah, D Zheng, RD Leslie

Diabetes represents a disease state, irrespective of the presence of clinical symptoms, determined by raised glucose or HbA1c levels. Diabetes has surged in prevalence in recent years, whether type 1... more

From mid-range to mildly reduced ejection fraction heart failure: A call to treat

13 June 2022
Author(s): Davide Stolfo, Enrico Fabris, Lars H. Lund, Gianluigi Savarese, Gianfranco Sinagra

The historical classification of heart failure (HF) has considered two distinct subgroups, HF with reduced ejection fraction (HFrEF), generally classified as EF below 40%, and HF with preserved... more

Epidemiology of portal vein thrombosis in liver cirrhosis: A systematic review and meta-analysis

7 June 2022
Author(s): Jiahui Pan, Le Wang, Fangbo Gao, Yang An, Yue Yin, Xiaozhong Guo, Filipe Gaio Nery, Eric M. Yoshida, Xingshun Qi

Liver cirrhosis is the 11th most common cause of death worldwide [1]. The number of deaths from liver cirrhosis increased from 899,000 in 1990 to 1,320,000 in 2017, constituting 2.4% of total deaths... more

Perspectives on the pharmacological management of alcohol use disorder: Are the approved medications effective?

18 May 2022
Author(s): Mariangela Antonelli, Luisa Sestito, Claudia Tarli, Giovanni Addolorato

Alcohol use disorder (AUD) is characterized by a large consumption of alcoholic beverages, which can determine the onset of alcohol-related diseases and an overall increase of morbidity and mortality... more

Treatment strategies of COVID-19: A rheumatology perspective

11 May 2022
Author(s): Alexandros A. Drosos, Eleftherios Pelechas, Paraskevi V. Voulgari

Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China at the end of 2019 and has developed into a pandemic. The disease has... more

Low serum albumin: A neglected predictor in patients with cardiovascular disease

7 May 2022
Author(s): Antonis A. Manolis, Theodora A. Manolis, Helen Melita, Dimitri P. Mikhailidis, Antonis S. Manolis

Albumin, the most abundant circulating protein in blood (accounting for 50% of the plasma proteins), composed of 585 amino acids with a molecular weight of 66 kDa, binds and transports various drugs... more

Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond

6 May 2022
Author(s): Cristina Morelli, Gessica Ingrasciotta, Daniel Jacoby, Ahmad Masri, Iacopo Olivotto

In recent years, constant progress in science and technology has resulted in innovative molecules addressing core mechanisms of myocardial disease affecting millions worldwide [1]. A targeted... more

Uric acid in metabolic syndrome: Does uric acid have a definitive role?

1 May 2022
Author(s): Sidar Copur, Atalay Demiray, Mehmet Kanbay

The final product of purine metabolism is uric acid (UA) which is produced by xanthine oxidase (XO). Although most mammalian species can also oxidize UA to allantoin via uricase, humans are thought... more

Renin-angiotensin-aldosterone system inhibition in patients affected by heart failure: efficacy, mechanistic effects and practical use of sacubitril/valsartan. Position Paper of the Italian Society of Cardiology

22 April 2022
Author(s): Pasquale Perrone-Filardi, Stefania Paolillo, Piergiuseppe Agostoni, Christian Basile, Cristina Basso, Francesco Barillà, Michele Correale, Antonio Curcio, Massimo Mancone, Marco Merlo, Marco Metra, Saverio Muscoli, Savina Nodari, Alberto Palazzuoli, Roberto Pedrinelli, Roberto Pontremoli, Michele Senni, Massimo Volpe, Ciro Indolfi, Gianfranco Sinagra

Renin-angiotensin-aldosterone system (RAAS) activation is one the main pathophysiological mechanisms involved in the development and progression of heart failure (HF) and its inhibition is a mainstay... more


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