The evidence that DNA was organized in a peculiar structure named "chromatin" and associated with proteins of unknown function was a very early finding. The term "chromatin" was first introduced by the German biologist Walther Flemming in the late 19th century [1]. He observed thread-like structures within the cell nucleus during cell division and named them "chromatin" due to their ability to be stained by certain dyes. Although Flemming's observations were fundamental to the study of chromatin, the detailed structure and function were unraveled much later through the collective work of numerous scientists in genetics, biochemistry, and molecular biology.
