August 2023

31 Articles

No Section

Ocular surface manifestations and SARS-CoV-2 RNA detection in conjunctival swabs of patients hospitalized for COVID-19 pneumonia

22 May 2023
Author(s): Zsuzsanna Valyi, Maria Khalil, Sigi Van den Wijngaert, François Willermain, Marie Bruyneel, COVID-19 Ocular Surface Study Group

Coronavirus disease 2019 (COVID-19) can appear with a wide range of clinical manifestations including respiratory, cardiovascular, gastrointestinal, neurological, dermatological, and ocular... more

Characteristics and clinical outcomes of patients with COVID-19 recurrent infection during the omicron variant predominance

15 May 2023
Author(s): Ran Abuhasira, Nitzan Burrack, Lior Nesher, Daniel Ostrovsky, Victor Novack

Reinfections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), were considered an uncommon event during the pre-omicron... more

Clinical Insights

Understanding the biological success of SARS-CoV-2: Immunoevasion strategies and beyond

2 June 2023
Author(s): Giuseppe Lippi, Brandon M. Henry

Although the epidemiology of Coronavirus Disease 2019 (COVID-19) has considerably changed over time, displaying a substantial decline in severe forms of illness and death rate [1], a recent claim by... more

Metabolically healthy obesity: does it exist?

5 May 2023
Author(s): Paolo Sbraccia

Excessive and/or abnormal adipose tissue accumulation due to positive energy balance leads to a chronic and progressive disease: obesity [1]. Its clinical impact due to the many disabling and deadly... more


The main thing is to keep the main thing as the main thing

17 July 2023
Author(s): José L. Zamorano

Medicine is the privilege of being able to help our patients with their illness. There is no doubt that this implies a huge continuous effort to keep up to date with medical knowledge. These advances... more

New therapeutic options for IgA nephropathy: Balancing risks and benefits

19 June 2023
Author(s): Roberto Pontremoli, Maria Carla Ghinatti

IgA nephropathy (IgAN), also known as Berger disease, is currently the most common primary glomerular disease worldwide, its prevalence and incidence varying significantly from 30 to 40 cases per... more

SGLT2-inhibitors: Should they be considered anti-remodeling drugs?

22 May 2023
Author(s): Enrico Fabris, Gianfranco Sinagra, Stefan D. Anker

Heart failure (HF) is a complex syndrome characterized by multiple aetiologies and a progressive clinical course with a strong impact in terms of morbidity, mortality and public health costs [1].

Uric acid and left ventricular mass in prediction of cardiovascular risk—New insight from the URRAH study

11 May 2023
Author(s): Sverre E. Kjeldsen, Julian E. Mariampillai, Aud Høieggen

The association between serum uric acid (SUA) levels and cardiovascular diseases has been investigated through decades. A large number of epidemiological studies have suggested an unfavorable impact... more

Internal Medicine Flashcard

Red eye and joint pain

9 May 2023
Author(s): Quentin Richier, Arthur Dubernet, Loïc Raffray

A 61-year-old woman reported a right ocular painful redness with photophobia, two weeks after a rheumatoid arthritis flare. She was daily treated with leflunomide. Visual acuity was at 20/250 on the... more

Massive splenomegaly

2 May 2023
Author(s): Moshe Giladi, Kenneth Hennrick, Daniel Shepshelovich

A 31-year-old Ashkenazi Jewish male presented to his primary care physician due to early satiety, nausea, abdominal discomfort, and occasional vomiting. Laboratory tests were within normal limits,... more

Hyperpigmentation on the dorsal tongue

2 May 2023
Author(s): Toshiki Namiki, Yuichiro Takeshita, Tomohiko Yoshida

A 73-year-old man diagnosed with brain metastasis from non-small cell lung carcinoma, not otherwise specified (NSCLC-NOS), was hospitalized for 1 week due to anorexia. A computed tomography revealed... more

Letter to the Editor

The lean paradox in pulmonary embolism: Beyond the estimated plasma volume?

29 May 2023
Author(s): Ivana Jurin, Marin Pavlov, Sime Manola, Vedran Radonic, Irzal Hadzibegovic

Dear Editor,

Prognostic value of left atrial strain in multiple myeloma

20 May 2023
Author(s): Pamela Piña, Daniel Lorenzatti, Patricia A. Pellikka, Nishi Shah, Leandro Slipczuk

The clonal proliferation of neoplastic plasma cells and the overproduction of monoclonal immunoglobulins promote the multi-system consequences of multiple myeloma (MM), which confers a high-risk of... more

Spironolactone is associated with reduced white matter lesion progression in patients with hypertension

15 May 2023
Author(s): Yujuan Yuan, Mulalibieke Heizhati, Yan Liu, Nanfang Li

White matter lesions (WMLs) in the brain are mostly caused by cerebral small vessel disease linked to traditional cardiovascular risk factors, which increase the risk of dementia, depression, stroke... more

Therapeutic challenges and cardiovascular risk in patients with HMGCR-associated immune-mediated necrotizing myopathy (HMGR-IMNM) secondary to statins

11 May 2023
Author(s): Jorge Álvarez-Troncoso, Sergio Carrasco Molina, Ángel Robles-Marhuenda, Elena Martínez-Robles, Juan José Ríos-Blanco

Idiopathic inflammatory myopathies (IIM) are connective tissue diseases (CTD) that involve muscle with varying severity [1]. They include polymyositis, dermatomyositis, overlap myositis, inclusion... more

Furosemide-associated hyponatremia in internal medicine patients: Analysis of epidemiological and biochemical profiles

10 May 2023
Author(s): Josef Klhůfek, Martin Vodička

the role of furosemide in the development of hyponatremia seems ambiguous. The data coming from a large retrospective population-based case-control study, focused on hospitalization due to... more

Chronic cough in very old patients on long-term therapy with angiotensin converting enzyme inhibitors and new-onset cancer

9 May 2023
Author(s): Antonella Gallo, Maria Grazia Massaro, Sara Camilli, Elena Verrecchia, Massimo Montalto

Dear editor

Pulmonary embolism, is it healthy to be volume expanded?

7 May 2023
Author(s): Marko Lucijanic, Ivan Krecak

We have read with great interest the paper by Jurin et al. [1] reporting adverse survival in pulmonary embolism (PE) patients belonging to the first body mass index (BMI) quartile. As the authors... more

Tirzepatide decreases systolic and diastolic blood pressure

10 April 2023
Author(s): Sidar Copur, Atalay Demiray, David Cherney, Katherine Tuttle, Mehmet Kanbay

Tirzepatide is a newer glucose-lowering medication with agonist activity on the glucagon-like peptide (GLP)−1 receptor as well as on the glucose-dependent insulinotropic polypeptide (GIP) receptor.... more

Original Article

Evaluation of machine learning algorithms for renin-angiotensin-aldosterone system inhibitors associated renal adverse event prediction

20 May 2023
Author(s): Alper Tuna Güven, Murat Özdede, Yusuf Ziya Şener, Ali Osman Yıldırım, Sabri Engin Altıntop, Berkay Yeşilyurt, Oğuz Abdullah Uyaroğlu, Mine Durusu Tanrıöver

Renin-angiotensin-aldosterone system inhibitors (RAASi) are a group of drugs that include angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB). Numerous randomized... more

Short sleep duration and atrial fibrillation risk: A comprehensive analysis of observational cohort studies and genetic study

13 May 2023
Author(s): Jun Chen, Fuhao Li, Yucheng Wang, Dongsheng Cai, Yijie Chen, Ziwei Mei, Lei Chen

Short sleep duration has a significant influence on individual health. Sleep duration can be affected by many factors, such as lifestyle, environmental factors, and sleep disorders (e.g., common... more

Comparative effectiveness and safety for the treatments despite optimized renin-angiotensin system blockade among IgA nephropathy patients at high-risk of disease progression: A network meta-analysis of randomized controlled trials

11 May 2023
Author(s): Qiong Tan, Hui Xue, Xiaoyan Ni, Lijun Fan, Wei Du

IgA nephropathy (Berger's disease) is the most common glomerular disease worldwide and often diagnosed in young adults, [1] with a heavy social and economic burden on our society [2,3]. It... more

Contribution of low skeletal muscle mass in predicting cardiovascular events: A prospective cohort study

8 May 2023
Author(s): Yiting Xu, Tingting Hu, Yun Shen, Yufei Wang, Yuqian Bao, Xiaojing Ma

Cardiovascular disease (CVD) is the largest single contributor to global mortality and accounts for more than 40% of deaths in China [1,2]. In China, there were estimated 93.8 million prevalent cases... more

Role of systemic immunosuppression on subglottic stenosis in granulomatosis with polyangiitis: Analysis of a single-centre cohort

6 May 2023
Author(s): Luca Moroni, Laura Giudice, Marco Lanzillotta, Adriana Cariddi, Giuseppe A. Ramirez, Enrica P. Bozzolo, Bruno Germinario, Gabriele Gallina, Stefano Viscardi, Angelo Carretta, Lorenzo Dagna

Subglottic stenosis (SGS) is defined as narrowing of the airway below the vocal cords and is a potentially life-threatening condition. Many aetiologies have been proposed in the literature for... more

Renal hyperfiltration revisited—Role of the individual body surface area on mortality

6 May 2023
Author(s): Päivi E. Korhonen, Mikael O. Ekblad, Hannu Kautiainen, Satu Mäkelä

Renal hyperfiltration (RHF) has been associated with mortality in several studies which have estimated glomerular filtration rate (eGFR) with the creatinine-based Chronic Kidney Disease Epidemiology... more

The impact of HCV chronic positivity and clearance on extrahepatic morbidity in thalassemia major patients: an observational study from MIOT Network

5 May 2023
Author(s): Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Anna Spasiano, Liana Cuccia, Massimo Allò, Giuseppe Messina, Valerio Cecinati, Calogera Geraradi, Rosamaria Rosso, Cristina Vassalle, Riccardo Righi, Stefania Renne, Massimiliano Missere, Vincenzo Positano, Alessia Pepe, Filippo Cademartiri, Paolo Ricchi

In the general population hepatitis C virus (HCV) infection is commonly correlated with the development of liver complication such as fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) [1,2].... more

Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project

23 April 2023
Author(s): Maria Lorenza Muiesan, Claudia Agabiti Rosei, Anna Paini, Edoardo Casiglia, Massimo Cirillo, Guido Grassi, Guido Iaccarino, Francesca Mallamaci, Alessandro Maloberti, Alberto Mazza, Alessandro Mengozzi, Paolo Palatini, Gianfranco Parati, Gianpaolo Reboldi, Giulia Rivasi, Elisa Russo, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Claudio Borghi, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

The association between serum uric acid levels (SUA) and cardiovascular (CV) disease has been extensively investigated in the last 3 decades. A large number of epidemiological studies have confirmed... more

The effect of sodium-glucose cotransporter-2 inhibitors on cardiac structure remodeling and function: A meta-analysis of randomized controlled trials

14 April 2023
Author(s): Gang Fan, Dian-Long Guo

Adverse cardiac remodeling (ACR) is not only one of the most important mechanisms of heart failure, but also the independent risk factor of mortality and morbidity for patients with cardiovascular... more

Review Article

Insight into increased risk of portal vein thrombosis in nonalcoholic fatty liver disease

15 June 2023
Author(s): Hang Gong, Huang Zhong, Hui-Mei Xu, Xiong-Chang Liu, Liang-Ping Li, De-Kui Zhang

With the increasing prevalence of obesity and metabolic deterioration, nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of liver diseases worldwide [1]. The disease spectrum... more

How epigenetics impacts on human diseases

3 June 2023
Author(s): Antonella Farsetti, Barbara Illi, Carlo Gaetano

The evidence that DNA was organized in a peculiar structure named "chromatin" and associated with proteins of unknown function was a very early finding. The term "chromatin" was first introduced by... more

Comparative analysis of level of evidence and class of recommendation for 50 clinical practice guidelines released by the European Society of Cardiology from 2011 to 2022

9 May 2023
Author(s): Giuseppe Boriani, Andrea Venturelli, Jacopo F Imberti, Niccolò Bonini, Davide A Mei, Marco Vitolo

The term “Evidence-based Medicine” (EBM) first appeared in medical literature in 1991 when Gordon Guyatt, a faculty member at McMaster Medical School in Hamilton, Ontario, published an Editorial... more


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