December 2017

17 Articles

No Section

Resistant hypertension: Renal denervation or intensified medical treatment?

27 December 2017
Author(s): Alberto Morganti, Giuseppe Mancia

Resistant hypertension (RH) can be diagnosed if blood pressure (BP) is not controlled with the combination of three antihypertensive drugs, including a diuretic, all at effective doses. Patients... more

Comparison of survival between hemodialysis and peritoneal dialysis patients with end-stage renal disease in the era of icodextrin treatment

3 December 2017
Author(s): I-Kuan Wang, Cheng-Li Lin, Tzung-Hai Yen, Shih-Yi Lin, Fung-Chang Sung

Icodextrin could reduce the risk of technique failure and improve patient survival in peritoneal dialysis (PD) patients. This study compared the survival between incident hemodialysis (HD) and PD... more

Letter to the Editor

Chronic obstructive pulmonary disease and community acquired pneumonia: Much more to clarify

27 December 2017
Author(s): María del Carmen Santos, Fernando Tornero, María José Núñez Orantos, Esther Rodríguez Adrada, Juan González del Castillo

Recently, De Miguel Diez et al. [1] have published an interesting study concluding that the incidence of hospitalizations for community acquired pneumonia (CAP) increased over time in patients with... more

What is the significance, if any, of the increased incidence of stent thrombosis with dual therapy of dabigatran 110mg twice daily and clopidogrel in the RE-DUAL PCI trial?

22 December 2017
Author(s): Andrea Rubboli

In the recent RE-DUAL PCI trial [1] where dual therapy of dabigatran, at the dose of both 110 and 150mg twice daily, and clopidogrel was compared with conventional triple therapy of warfarin, aspirin... more

Etiology of discharge hyponatremia in decompensated heart failure and normal admission Na+: Effect of diuretics

21 December 2017
Author(s): Hesham R. Omar, Maya Guglin

Hyponatremia is the commonest electrolyte abnormality in hospitalized patients [1]. Patients with decompensated heart failure (HF) commonly have electrolyte abnormalities, due to the activation of... more

Thyroid replacement therapy might undermine hypothyroidism-related longevity

18 December 2017
Author(s): Oscar M.P. Jolobe

The observation that thyroid replacement therapy increases mortality in elderly subjects with subclinical hypothyroidism [1] has, as its converse, the documentation of an association between... more

Renal function evaluation in liver cirrhosis: Preliminary report on the effect of the Royal Free Hospital Cirrhosis Glomerular Filtration Rate on the Model for End-Stage Liver Disease (MELD)

16 December 2017
Author(s): Gaetano Bergamaschi, Michela Masotti, Gino Roberto Corazza

Serum creatinine and estimated glomerular filtration rate (eGFR), determined using the Modification of Diet Renal Disease (MDRD)-4, the MDRD-6 or the Chronic Kidney Disease Epidemiology Collaboration... more

The Kampala declaration on sepsis – The recognition and treatment of severe illness starts at the bedside by recording vital signs

15 December 2017
Author(s): Emmanuel Fru Nsutebu, John Kellett

“Improving prevention and management of sepsis involves providing basic health care services such as recording vital signs and other necessary measures for all patients in order to identify and... more

Risk scores for outpatient management of febrile neutropenia: Is the MASCC slipping?

4 December 2017
Author(s): Tim Cooksley, Shin Ahn, Thomas Knight, Terry W. Rice

In response to our recent narrative review [1], Carmona-Bayonas et al. question whether the Clinical Index of Stable Febrile Neutropenia (CISNE) or Multinational Association of Supportive Care in... more

External validation of mortality prognostic indices after hospital discharge in older adults

2 December 2017
Author(s): Alberto Socorro García, María de la Puente Martín, Juan J. Baztán

Prognostic indices of mortality in the elderly population may be useful to the clinician: they provide a mortality objective estimation that complements clinical judgment when giving information to... more

Pope Francis and the end-of-life: Time for serious reflection

2 December 2017
Author(s): A. Perciaccante, P. Charlier, A. Coralli, S. Deo

On November 16, 2017 Pope Francis intervened at the European regional meeting of World Medical Association by sending a message about the complex subject of “end of life” [1]. Already in 1957, Pope... more

Immunohistochemistry as confirmatory test for current Helicobacter pylori infection in patients treated with proton pump inhibitors

1 December 2017
Author(s): Anca Negovan, Mihaela Iancu, Simona Mocan, Claudia Banescu

We would like to thank Dr. Davide Giuseppe Ribaldone and colleagues for their interest in our article “The contribution of clinical and pathological predisposing factors to severe gastro-duodenal... more

Pneumocystis jirovecii pneumonia in patients treated with rituximab for systemic diseases: Report of 11 cases and review of the literature

30 November 2017
Author(s): K. Alexandre, S. Ingen-Housz-Oro, M. Versini, L. Sailler, Y. Benhamou

During the last decades, the number of Pneumocystis jirovecii pneumonia (PJP) has grown in HIV-negative patients due to the increasing use of organ transplantation, immunosuppressive drugs and... more

Original Article

Multifaceted intervention to curb in-hospital over-prescription of proton pump inhibitors: A longitudinal multicenter quasi-experimental before-and-after study

20 December 2017
Author(s): Rosaria Del Giorno, Alessandro Ceschi, Michela Pironi, Anna Zasa, Angela Greco, Luca Gabutti

Proton pump inhibitors (PPIs) are indicated for a restricted number of clinical conditions, and their misuse can lead to several adverse effects. Despite that, the proportion of overuse is alarmingly... more

Comparison of the effect of allopurinol and febuxostat on urinary 2,8-dihydroxyadenine excretion in patients with APRT deficiency: A clinical trial

12 December 2017
Author(s): Vidar O. Edvardsson, Hrafnhildur L. Runolfsdottir, Unnur A. Thorsteinsdottir, Inger M. Sch. Agustsdottir, G. Steinunn Oddsdottir, Finnur Eiriksson, David S. Goldfarb, Margret Thorsteinsdottir, Runolfur Palsson

Adenine phosphoribosyltransferase (APRT) deficiency is a rare, but significant, cause of kidney stones and progressive chronic kidney disease. The optimal treatment has not been established. The... more

Pretransplant coronary artery disease is a predictor for myocardial infarction and cardiac death after liver transplantation

8 December 2017
Author(s): F. Darstein, M. Hoppe-Lotichius, J. Vollmar, V. Weyer-Elberich, A. Zimmermann, J. Mittler, G. Otto, H. Lang, P.R. Galle, T. Zimmermann

Cardiovascular disease is a serious problem of liver transplant (LT) recipients because of increased cardiovascular risk due to immunosuppressive therapy, higher age, intraoperative risk and... more

Endocrine and metabolic assessment in adults with Langerhans cell histiocytosis

29 November 2017
Author(s): L. Montefusco, S. Harari, D. Elia, A. Rossi, C. Specchia, O. Torre, G. Adda, M. Arosio

Diabetes insipidus (DI) is one of most common complications of Langerhans cell histiocytosis (LCH) but prevalence of anterior pituitary deficiencies and metabolic alterations have not been clearly... more


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