We read with a great interest the article of Sansanayudh et al. about mean platelet volume (MPV) and cardiovascular risk factors [1]. They found that the higher MPV associated with some cardiovascular risk factors like female gender, diabetes mellitus, metabolic syndrome, serum triglyceride, hypertension and pre-hypertension in data of the Electricity Generating Authority of Thailand (EGAT) cohort. We would like to comment on this paper.