January 2016

32 Articles

No Section

Adverse drug reactions and organ damage: The liver

27 January 2016
Author(s): Anna Licata

Drug-induced liver injury (DILI) is among the most challenging acute or chronic liver conditions to be handled by physicians. Despite its low incidence in the general population, DILI is a frequent... more

Developments in Internal Medicine

A case of familial partial lipodystrophy caused by a novel lamin A/C () mutation in exon 1 (D47N)

7 January 2016
Author(s): Nilufer Ozdemir Kutbay, Banu Sarer Yurekli, Huseyin Onay, Canan Tuncer Altay, Tahir Atik, Zeliha Hekimsoy, Fusun Saygili, Baris Akinci

Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective lack of subcutaneous fat which is associated with insulin resistant diabetes. The Dunnigan variety (FPL2) is... more

Letter to the Editor

Profile of serum biomarkers in eosinophilic disorders

19 January 2016
Author(s): Grzegorz Helbig, Tomasz Francuz, Marek Hus, Katarzyna Wiśniewska-Piąty, Sławomira Kyrcz-Krzemień

The term hypereosinophilia (HE) refers to persistent and marked blood eosinophilia which is documented on two occasions, with or without an additional tissue eosinophilia. The persistence of HE... more

Efficacy and effectiveness of sublingual immunotherapy for grass pollen allergy: Reply to the letter of Marcucci F

15 January 2016
Author(s): Corrao Salvatore

I have read the letter of Marcucci [1] with great attention. First of all, It could be useful to underline that the criticized paper is an editorial, not surprisingly written by an editor, and, in... more

Direct new oral anticoagulants in the emergency department: Experience in everyday clinical practice at a Swiss university hospital

5 January 2016
Author(s): Thomas C. Sauter, Anna-Lea Amylidi, Meret E. Ricklin, Beat Lehmann, Aristomenis K. Exadaktylos

Since 2009, an increasing number of patients presenting to emergency departments (ED) are on anticoagulant medication with the newer direct oral anticoagulants (NOAC), such as rivaroxaban (Xarelto),... more

Disease severity scoring system for non-transfusion-dependent thalassemia

4 January 2016
Author(s): Somsri Wiwanitkit, Viroj Wiwanitkit

The recent report on “disease severity scoring system for non-transfusion-dependent thalassemia (NTDT)” is very interesting [1]. Cappellini et al. proposed for a new system and concluded that “this... more

Letters to the Editor

Therapeutic behavior of primary care physicians in patients with atrial fibrillation taking vitamin K antagonists not adequately controlled

27 January 2016
Author(s): Carlos Escobar, Vivencio Barrios, Luis Prieto

In the majority of patients with atrial fibrillation (AF), long-term oral anticoagulation is necessary to reduce the risk of stroke. Although effective, vitamin K antagonists (VKAs) exhibit many... more

Carbon monoxide poisoning and risk for ischemic stroke

19 January 2016
Author(s): Neil B. Hampson, Lindell K. Weaver

As specialists in carbon monoxide (CO) poisoning, we noted with interest the paper in European Journal of Internal Medicine this year by Kao and co-workers examining the diagnosis of other diseases... more

V/Q scan or CTPA for the detection of pulmonary embolism?

18 January 2016
Author(s): Sophy Hitchen, Jacqueline James, Jecko Thachil

Competing interests: None.

Utility of NT-proBNP in predicting infarct scar and left ventricular dysfunction at a chronic stage after myocardial infarction

8 January 2016
Author(s): Sebastian Johannes Reinstadler, Hans-Josef Feistritzer, Martin Reindl, Gert Klug, Bernhard Metzler

Infarct healing is a dynamic process, characterized by a marked reduction of infarct size within the first months, followed by a more gradual reduction through the first year after STEMI [1]. CMR... more

Association of troponin levels below the 99th percentile with outcomes in patients with acute chest pain

7 January 2016
Author(s): Alberto Bouzas-Mosquera, Jesús Peteiro, Ignacio Pedro Constanso, Nemesio Álvarez-García, José Manuel Vázquez-Rodríguez

We thank Drs. Lippi and Cervellin for their interest in our report [1] and for their thoughtful comments [2]. We agree that patients with suspected acute coronary syndromes and serial cardiac... more

Training programs throughout Europe in Internal Medicine: Are there critical differences between northern and southern countries? An international survey

6 January 2016
Author(s): Pablo Ruiz Sada, Itziar Garmendia Antía, Miriam López Martínez

There is a lack of current data about training programs in Internal Medicine as well as disparity in their approaches. A 69 item survey was carried out and given to 39 residents of Internal Medicine... more

The new task for medical scientists

5 January 2016
Author(s): Maurizio Bifulco

Not just solid knowledge and pronounced attitude to research: currently, the ability to communicate regarding health and disease problems seems to be a required quality in the scientific community.... more

Original Article

Cognitive ability in Swedish conscripts and future risk of venous thromboembolism: A co-relative prospective national study

27 January 2016
Author(s): Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist

Cognitive ability measured via an IQ-test (intelligence quotient) has been associated with cardiovascular (CVD) incidence. Whether cognitive ability is associated with risk of venous thromboembolism... more

Systemic mastocytosis: A cohort study on clinical characteristics of 136 patients in a large tertiary centre

22 January 2016
Author(s): Maud A.W. Hermans, Mark J.A. Rietveld, Jan A.M. van Laar, Virgil A.S.H. Dalm, Maurice Verburg, Suzanne G.M.A. Pasmans, Roy Gerth van Wijk, P. Martin van Hagen, Paul L.A. van Daele

Systemic mastocytosis (SM) is a rare heterogeneous disease which is characterized by the aberrant proliferation of mast cells. It can be divided into various subtypes with different phenotypes and... more

Acute pancreatitis in elderly patients: A retrospective evaluation at hospital admission

21 January 2016
Author(s): Giuseppe Losurdo, Andrea Iannone, Mariabeatrice Principi, Michele Barone, Nunzio Ranaldo, Enzo Ierardi, Alfredo Di Leo

Acute pancreatitis (AP) in elderly may have an aggressive course due to co-morbidity high rate and severe presentation. We retrospectively evaluated AP severity and its underlying factors in a group... more

New Atlanta Classification of acute pancreatitis in intensive care unit: Complications and prognosis

20 January 2016
Author(s): María-Consuelo Pintado, María Trascasa, Cristina Arenillas, Yaiza Ortiz de Zárate, Ana Pardo, Aaron Blandino, Raúl de Pablo

The updated Atlanta Classification of acute pancreatitis (AP) in adults defined three levels of severity according to the presence of local and/or systemic complications and presence and length of... more

Renal insufficiency and mortality in coronary artery disease with reduced ejection fraction

19 January 2016
Author(s): Yong Peng, Tian-Li Xia, Wei Liu, Bao-Tao Huang, Zhen-Gang Zhao, Fang-Yang Huang, Chen Zhang, Yan-Biao Liao, Hua Chai, Xiao-Lin Luo, Qiao Li, Yuan-Ning Xu, Chi Chen, Qing-Tao Meng, Mao Chen, De-Jia Huang

Despite strong evidence linking decreased estimated glomerular filtration rate (eGFR) to worse cardiovascular outcome, the impact of eGFR on mortality in coronary artery disease (CAD) patients with... more

Chronic kidney disease referral practices among non-nephrology specialists: A single-centre experience

19 January 2016
Author(s): Jesmar Buttigieg, Liam Mercieca, Arielle Saliba, Simon Aquilina, Emanuel Farrugia, Stephen Fava

Early referral of CKD patients to nephrology teams (NT) is vital to identify patients most likely to progress, delay decline of excretory function, and provide planned RRT. Unfortunately, many are... more

Impact of left ventricular remodeling and renal function on 24h-ECG recordings and cardiovascular outcome in elderly hypertensive patients

15 January 2016
Author(s): Agata Buonacera, Marouane Boukhris, Salvatore D. Tomasello, Andrea Campagna, Chiara Cilia, Giovanni Tripepi, Salvatore Di Marca, Valentina Terranova, Marcella Pisano, Gianluca Mastrosimone, Alfredo R. Galassi, Benedetta Stancanelli, Alessandro Cataliotti, Lorenzo Malatino

The prognostic role of left ventricular remodeling and renal function in elderly hypertensive patients has been so far scarcely investigated.

Changes in lipid and carbohydrate metabolism under mTOR- and calcineurin-based immunosuppressive regimen in adult patients after liver transplantation

14 January 2016
Author(s): Anca Zimmermann, Christina Zobeley, M.M. Weber, H. Lang, Peter R. Galle, Tim Zimmermann

Cardiovascular disease is a leading cause of long-term mortality after liver transplantation (LT). Life long immunosuppression harbors the risk of metabolic alterations. We aimed to analyze the... more

Exploring the preventable causes of unplanned readmissions using root cause analysis: Coordination of care is the weakest link

13 January 2016
Author(s): K.S. Fluitman, L.S. van Galen, H. Merten, S.M. Rombach, M. Brabrand, T. Cooksley, C.H. Nickel, C.P. Subbe, M.H.H. Kramer, P.W.B. Nanayakkara, On behalf of the safer@home consortium

Unplanned readmissions within 30days are a common phenomenon in everyday practice and lead to increasing costs. Although many studies aiming to analyze the probable causes leading to unplanned... more

Temporal trends in the outcomes of patients with acute myocardial infarction associated with renal dysfunction over the past decade

13 January 2016
Author(s): David Rott, Robert Klempfner, Ilan Goldenberg, Shlomo Matetzky, Avishay Elis

Patients with renal dysfunction (RD) who present with acute myocardial infarction (AMI) are at a high risk for subsequent cardiovascular morbidity and mortality. We sought to evaluate changes in the... more

Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults

9 January 2016
Author(s): Leyre Riancho-Zarrabeitia, Mayte García-Unzueta, Jair A. Tenorio, Juan A. Gómez-Gerique, Víctor L. Ruiz Pérez, Karen E. Heath, Pablo Lapunzina, José A. Riancho

Low serum levels of alkaline phosphatase (ALP) are a hallmark of hypophosphatasia. However, the clinical significance and the underlying genetics of low ALP in unselected populations are unclear.

Ankle brachial index most important to identify polyvascular disease in patients with non-ST elevation or ST-elevation myocardial infarction

8 January 2016
Author(s): Birgitta Jönelid, Nina Johnston, Lars Berglund, Bertil Andrén, Björn Kragsterman, Christina Christersson

Atherosclerosis is a systemic disease. In patients with acute myocardial infarction (MI) the extent of polyvascular disease (PvD) is largely unknown. In this study we investigate the prevalence and... more

A risk score for prediction of recurrence in patients with unprovoked venous thromboembolism (DAMOVES)

7 January 2016
Author(s): A.I. Franco Moreno, M.J. García Navarro, J. Ortiz Sánchez, R.M. Martín Díaz, E. Madroñal Cerezo, C.L. de Ancos Aracil, N. Cabello Clotet, I. Perales Fraile, S. Gimeno García, C. Montero Hernández, A. Zapatero Gaviria, J.M. Ruiz Giardín

In patients with unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is anchored on estimating the risk of disease recurrence. We aimed to develop a simple risk... more

Therapy modifications during hospitalization in patients with chronic heart failure

7 January 2016
Author(s): Andreja Detiček, Igor Locatelli, Tina Roblek, Aleš Mrhar, Mitja Lainscak

Background: Guidelines on suggested pharmacological treatments for heart failure (HF) are not optimally implemented in clinical practice and whether pharmacotherapy adjustment actually happens in... more

Renin–angiotensin–aldosterone system inhibitors lower hemoglobin and hematocrit only in renal transplant recipients with initially higher levels

7 January 2016
Author(s): I. Mikolasevic, L. Zaputovic, L. Zibar, I. Begic, M. Zutelija, A. Klanac, I. Majurec, T. Simundic, M. Minazek, L. Orlic

We have analyzed the effects of renin–angiotensin–aldosterone system (RAAS) inhibitors on evolution of hemoglobin (Hb) and hematocrit (Htc) levels as well as on the evaluation of kidney graft... more

The alertness, gait and mortality of severely ill patients at two months after admission to a resource poor sub-Saharan hospital—Why is post-discharge surveillance not routine everywhere?

6 January 2016
Author(s): Barbara Nabayigga, John Kellett, Martin Otyek Opio

Mortality, the first level of the first tier of the Outcomes Measures Hierarchy used to assess the value of health care, is the only hospital outcome usually measured. Gait and alertness after... more

The association between mean platelet volume and cardiovascular risk factors

6 January 2016
Author(s): Nakarin Sansanayudh, Dittapol Muntham, Sukit Yamwong, Piyamitr Sritara, Tawatchai Akrawichien, Ammarin Thakkinstian

Mean platelet volume (MPV) correlates with platelet activation and has recently emerged as a potential marker of cardiovascular diseases. Previous publications also suggest possible association... more

High on-aspirin platelet reactivity predicts cardiac death in acute coronary syndrome patients undergoing PCI

4 January 2016
Author(s): Anna Maria Gori, Elisa Grifoni, Renato Valenti, Betti Giusti, Rita Paniccia, Guido Parodi, Angela Migliorini, David Antoniucci, Rosanna Abbate, Gian Franco Gensini, Rossella Marcucci

To evaluate the possible role of high on-aspirin platelet reactivity (HaPR) in a prospective cohort of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI).

Review Article

Kounis syndrome: A concise review with focus on management

12 January 2016
Author(s): Filippo Fassio, Laura Losappio, Dario Antolin-Amerigo, Silvia Peveri, Gianni Pala, Donatella Preziosi, Ilaria Massaro, Gabriele Giuliani, Chiara Gasperini, Marco Caminati, Enrico Heffler

Kounis syndrome is defined as the co-incidental occurrence of an acute coronary syndrome with hypersensitivity reactions following an allergenic event and was first described by Kounis and Zavras in... more


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