January 2025

153 Articles

No Section

Hydroxychloroquine use in patients with primary immune thrombocytopenia and antiphospholipid antibodies

13 January 2025
Author(s): Fernando Porto, Artur Saldanha, Erica Okazaki, Paula Villaça, Fernanda A. Orsi

The prevalence of antiphospholipid antibodies (aPL) among patients with immune thrombocytopenia (ITP) is high, at 20 % or higher according to previous studies [1,2].

Beyond the Guidelines

Elevated blood pressure and hypertension in older persons: A comment on the recent ESC guidelines

23 October 2024
Author(s): Giulia Rivasi, Enrico Brunetti, Roberto Presta, Niccolò Marchionni, Giovambattista Desideri, Mario Bo, Italian Society of Geriatric Cardiology (SICGe)

The recently published European Society of Cardiology (ESC) Guidelines (GLs) for the management of elevated blood pressure (BP) and hypertension [1] introduced substantial changes in recommendations... more

Clinical Insights

Redefining giant cell arteritis: From current practices to future paradigms

9 December 2024
Author(s): Alessandro Tomelleri, Nicola Farina, Lorenzo Dagna

The management of patients with giant cell arteritis (GCA), the most common vasculitis in adults, has undergone significant transformation over the past decade [1]. This shift has been primarily... more

The assessment, interpretation and implementation of lung ultrasound examinations in Heart Failure: Current evidence and gaps in knowledge

17 October 2024
Author(s): Alberto Palazzuoli, Matteo Beltrami, Nicolas Girerd, Anna Maw, Gaetano Ruocco, Elke Platz

Pulmonary congestion is a common finding of volume overload or volume shift in heart failure (HF) and its detection is essential to facilitate timely therapy initiation or adjustment prior to frank... more

The screening of cognitive impairment in the emergency department: A valuable clinical and epidemiological goal

14 October 2024
Author(s): Raffaele Antonelli-Incalzi, Camillo Marra

The screening of cognitive impairment is a critical and underestimated problem in the Emergency Department (ED). Overall, dementia remains unrecognized in more than a half of the Italian population,... more

Commentary

Sodium bicarbonate in metabolic acidosis: A never-ending story?

24 December 2024
Author(s): Giovanna Guiotto

Is it useful to treat metabolic acidosis with bicarbonate or not? This question is still one of the hot topics that doctors deal with in their daily clinical practice, mainly due to the lack of clear... more

Pulmonary metastases and bleeding in the anticoagulated oncology patient with thrombosis: is the risk solely influenced by the location of distant disease?

20 December 2024
Author(s): Manuel Sánchez Cánovas, Javier López Robles

The article by García-García V et al. [1], published in this issue of the European Journal of Internal Medicine,provides a valuable exploration of hemorrhagic complications in cancer-associated... more

Primordial prevention of hypertension

8 December 2024
Author(s): Claudio Ferri

Periculum in mora

Hypertension and heart failure: A dangerous relationship with clinical implications

29 November 2024
Author(s): Nicola Riccardo Pugliese, Simona Buralli, Stefano Taddei

Heart failure (HF) is currently classified into three categories, according to left ventricular (LV) ejection fraction (LVEF): HF with reduced ejection fraction (HFrEF; LVEF <40%), HF with mid-... more

Risk factors for community-acquired acute kidney injury: Challenges and perspectives

29 November 2024
Author(s): Elisa Russo, Francesca Cappadona, Pasquale Esposito

Acute kidney injury (AKI), even in its milder forms, significantly contributes to increased morbidity and mortality among both hospitalized and non-hospitalized individuals. However, AKI is now... more

Exploring predictors of pulmonary embolism in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease

17 November 2024
Author(s): Javier de Miguel-Díez, Zichen Ji

In this issue of the European Journal of Internal Medicine, Mismetti et al. published an original article titled "Predictors of pulmonary embolism in chronic obstructive pulmonary diseases patients... more

Hypertension management: The lesson from the SARS-CoV-2 pandemic

9 November 2024
Author(s): Lanfranco D'Elia

Hypertension is a major risk factor for cardiovascular diseases and a major cause of premature death worldwide [1]. Its regular monitoring is crucial for reducing cardiovascular risk, since it is the... more

“Obesity management in the older age, new understanding for old challenges”

7 November 2024
Author(s): Dror Dicker, Nursel Çalık Başaran, Volkan Demirhan Yumuk

Obesity, a silent pandemic, is rapidly spreading across all age groups and populations worldwide. >1 billion individuals are expected to be living with obesity by 2030 [1]. Parallel to the obesity... more

The new ESC 2024 guidelines on the management of peripheral arterial and aortic diseases: Lights and shadows

5 November 2024
Author(s): Claudio Cimminiello, Mauro Molteni

The new guidelines on the management of peripheral arterial and aortic diseases have been released at the European Society of Cardiology (ESC) Annual Congress 2024 and published simultaneously [1].... more

Hyperhomocysteinaemia and MASLD: Causal relationship or spurious correlation?

4 November 2024
Author(s): Thomas van Sloten, Willem Pieter Brouwer, Jurgen H. Runge, Karel J. van Erpecum

Metabolic dysfunction-associated liver disease (MASLD) is the most common chronic liver disease worldwide and a leading cause of liver-related morbidity and mortality, affecting one-third-of the... more

Linking functional capacity and heart failure outcomes: Easy assessment, major implications

9 October 2024
Author(s): Maria Perotto, Enrico Fabris, Gianfranco Sinagra

Heart failure (HF) is a global pandemic that affects nearly 60 million people worldwide. Despite continuous and significant advances in treatment, HF continues to be associated with poor prognosis... more

Realizing the scope of venous and arterial thrombosis in cyclin-dependent kinase 4/6 inhibitors in hormone positive breast cancer

7 October 2024
Author(s): Cy R. Wilkins, Jeffrey I. Zwicker

In hormone positive, human epidermal growth factor receptor 2 (HER2)-negative advanced and metastatic breast cancer, the cyclin-dependent kinase (CDK) 4/6 inhibitors palbociclib, ribociclib and... more

Treatment of systemic lupus erythematosus in real life

1 October 2024
Author(s): Giuseppe Barilaro, Ricard Cervera

The study by Du et al., published in this issue of the European Journal of Internal Medicine [1] adds significant information regarding the treatment patterns in systemic lupus erythematosus (SLE),... more

Editorial

A new era in optimization of anti-infective therapy: Current challenges and priorities

23 November 2024
Author(s): Jordi Rello, Virginie Prendki, Grant W. Waterer

Managing infectious diseases is an ever increasing challenge keeping pace with rising antimicrobial resistance, emerging pathogens and changing treatment paradigms. In a changing world, COVID-19,... more

Two recent European guidelines on hypertension

27 October 2024
Author(s): Paolo Verdecchia, Fabio Angeli, Giacomo Pucci, Giovanni de Simone, Gianpaolo Reboldi

During the past year, two influential Hypertension Guidelines from Europe have been released. The first, published in year 2023, was issued by the European Society of Hypertension [1]. The second,... more

Internal Medicine Flashcard

A 73-year-old man with purpura and fever

15 January 2025
Author(s): Ivânia Soares, Inês Pereira Amaral, Paulo Filipe

A 73-year-old man presented to our dermatology department with a four-week history of palpable purpura on the lower limbs. His medical history included a suspicion of polymyalgia rheumatica based on... more

An uncommon and unexpected cause of chest pain: When stockings become trauma

9 January 2025
Author(s): Janneke JC Bastings, Renée Brüggemann, Bart Spaetgens

An 80-year-old woman presented to the emergency department (ED) with acute sternal pain that began after removing her compression stockings. Three days earlier, she experienced a similar episode... more

Female patient with telangiectasia, epistaxis and pulmonary arteriovenous malformation

9 December 2024
Author(s): Fırat Akagunduz, Feride Yagmur Akagunduz, Fergun Yılmaz, Haner Direskeneli

A 55-years-old female patient was admitted to our clinic with a long-standing complaint of epistaxis. She had no medical history and was not taking any medications. Both her children had nosebleeds.... more

Generalized bullous fixed drug eruption

3 December 2024
Author(s): Li Chen, Junfeng Zhou, Lei Yao

A 73-year-old female presented with a diffuse rash accompanied by itching for 3 days. She had taken levofloxacin orally for a cough one day before the rash developed. She had a 16-year history of... more

Esophagitis in an immunocompetent patient: A diagnostic challenge

3 December 2024
Author(s): Shiori Kitaya, Takahiro Yoshinobu, Hajime Kanamori

A 65-year-old man with Parkinson's disease was admitted to hospital for continuous subcutaneous infusion of levodopa/carbidopa. On day 6 of hospitalization, he developed pharyngalgia, sensation of... more

Man with red eyes

1 December 2024
Author(s): Naoya Ishibashi, Tomotaka Takanosu

A 71-year-old male presented to our hospital with vertigo. The supine roll test induced vertigo, leading to a diagnosis of left horizontal semicircular canal benign paroxysmal positional vertigo (... more

Coronary artery pulsatile ectasia and multiple occlusion in an adolescent male

30 November 2024
Author(s): Junwen Wang, Xuefeng Chen, Yong Peng

An adolescent male was referred to our hospital due to dyspnea persisting for over a month. He has no previous medical illness and is not taking any medications. There was no history of smoking or... more

Hemiatrophy of the face and limb

30 November 2024
Author(s): Jiahao Wei, Xi Liu, Lifen Chen

A 64-year-old man presented to the Department of Neurology with recurrent head discomfort for over eight years and right-side facial and limb atrophy for five years. The head discomfort usually... more

A woman with unconsciousness and tachycardia after drug overdose.

13 November 2024
Author(s): Minori Kuromiya, Junpei Komagamine

A 44-year-old female was brought to our emergency department due to impaired consciousness. On arrival, her Glasgow Coma Scale score was 6. Her blood pressure was 102/60 mmHg, her heart rate was 132... more

A tiny green lesion mimicking a big problem

15 October 2024
Author(s): Luis Gorospe, Rosa Mariela Mirambeaux-Villalona, Paola Arrieta

A 75-year-old smoker patient presented to our hospital with shortness of breath and mild hemoptysis. A chest radiograph demonstrated a suspicious left parahilar opacity (Fig. 1A). A thoracic computed... more

Reversible polyneuropathy with multiple hypochromic lesions, digital ulcers and onychodystrophy

14 October 2024
Author(s): María Ezquerra-Marigómez, Mercedes Misiego, Javier Riancho

A 40-year-old Brazilian woman with a medical history of a subclinical hypothyroidism came to our clinic because of progressive distal numbness, weakness and polyarthralgia. She denied fever nor... more

Invited Review Article

Behaviour therapy for obesity in older adults

1 November 2024
Author(s): Meltem Koca, Laurence J Dobbie, Andreea Ciudin, Meltem Halil

Obesity is a major public health concern, with global data highlighting that 650 million adults are living with obesity and 1.9 billion adults are living with overweight [1]. Current epidemiological... more

Treat the patient, not the disease: The embolic stroke of undetermined source as an opportunity to optimize cardiovascular prevention in a holistic approach

23 October 2024
Author(s): George Ntaios, Mayank Dalakoti

“It is much more important to know what sort of patient has a disease than what sort of disease a patient has.”“The good physician treats the disease; the great physician treats the patient who has... more

Pharmacotherapy for older people with obesity

18 June 2024
Author(s): Luke D. Boyle, Feray Akbas, Dilek Yazıcı, Barbara M. McGowan, Volkan Yumuk

The prevalence of obesity continues to rise in Europe, particularly in adults aged between 60 and 74 years [1]. Despite this rising prevalence of obesity in older adults, use of medication for weight... more

Letter to the Editor

Trends in industry-sponsored research payments to internist principal investigators

17 January 2025
Author(s): Aurora J. Grutman, Zeyad Hammadeh, Joseph G. Cheaib, Evans K.H. Brown, Misop Han

In the United States, the Physician Payments Sunshine Act, passed by Congress as part of the 2010 Affordable Care Act, has brought greater transparency to financial relationships between industry and... more

Optimal BMI cutoff for lean MASLD/MetALD and adverse hepatic outcomes in East-Asian populations

13 January 2025
Author(s): Byungyoon Yun, Juyeon Oh, Heejoo Park, Beom Kyung Kim, Jin-Ha Yoon

Nonalcoholic fatty liver disease (NAFLD) is a primary contributor to hepatocellular carcinoma (HCC)/liver cirrhosis (LC), affecting ∼30 % of the global population. Its incidence is rising parallel to... more

Refining insights into rheumatoid arthritis-associated liver dysfunction: Opportunities for methodological advancements and clinical implications

13 January 2025
Author(s): Zhongxing Liu, Peng Guo, Guohong Xiang, Lincheng Duan

We read with great interest the article by Arias-de la Rosa et al., published in the European Journal of Internal Medicine [1]. This study provides valuable evidence that patients with rheumatoid... more

Vaginal self-sampling for human papillomavirus to improve cervical cancer screening in patients with immune-mediated inflammatory diseases

12 January 2025
Author(s): Tiphaine Goulenok, Chrystelle François, Valentine Marie Ferré, Arthur Mageau, Karim Sacré, APOSY Study Group

Dear Editor,

Reevaluating hypoxia and cancer as determinants of prognosis in COPD and Takotsubo syndrome

12 January 2025
Author(s): Gonzalo García-Martí, Ravi Vazirani, Hernán Mejía-Rentería, Iván J. Núñez-Gil

Dear Editor,

Internists at the frontline of epidemic viral illnesses: From tiredness to preparedness

9 January 2025
Author(s): Fabian Patauner, Raffaella Gallo, Emanuele Durante-Mangoni, Lorenzo Bertolino

In the wake of the coronavirus disease 2019 (COVID-19) pandemic, who would reasonably declare that a time will ever come «to close the book on infectious diseases»? Indeed, new viral threats are... more

The evolving role of head up tilt test: New protocol and indications for optimizing the care of syncope patients

3 January 2025
Author(s): Vincenzo Russo, Erika Parente, Angelo Comune, Gerardo Nigro, Michele Brignole

Dear Editor, we read with great interest the metanalysis by Guida et al. [1] about the diagnostic held of head up tilt test (HUTT) in patients with suspected vasovagal (VVS) syncope. The authors... more

Rituximab in Immune-mediated thrombotic thrombocytopenic purpura

2 January 2025
Author(s): Jie Li, Jiashuo Guo, Ruirui Yuan, Liying Xue

Thrombotic thrombocytopenic purpura (TTP) is a rare and potentially fatal thrombotic microangiopathy, defined by a mechanical hemolytic anemia, severe thrombocytopenia, and visceral ischemia due to... more

Associations of cardiovascular health and exercise capacity with moderate-to-vigorous physical activity prior to enrolment to cardiac rehabilitation in coronary artery disease patients

30 December 2024
Author(s): Tim Kambič, Esmée A. Bakker, Thijs M.H. Eijsvogels, Vedran Hadžić, Mitja Lainscak

Exercise training is a core component of cardiac rehabilitation (CR) and is associated with improvement in (sub)maximal exercise capacity, quality of life, and a reduction in the risk of re-... more

Refining the understanding of cardiovascular risk following COPD exacerbations: Opportunities for stratified and multidisciplinary approaches

24 December 2024
Author(s): Rujian Yu, Lamei Zou

We have carefully reviewed the article by Calabria et al., published in the European Journal of Internal Medicine [1]. This study, based on a comprehensive database analysis, highlights the... more

Refining risk assessment for intra-abdominal infections in immunocompromised intensive care unit patients

24 December 2024
Author(s): Yinfang Wu, Qi Zhao

The study by Paiva and colleagues [1] provides valuable insights into intra-abdominal infections (IAI) in immunocompromised intensive care unit (ICU) patients, highlighting similarities and... more

Analysis of “characteristics of familial mediterranean fever disease after 65 years of age”

18 December 2024
Author(s): Kazim Besirli

I have read the article “Characteristics of Familial Mediterranean fever (FMF) after 65 years of age” with great interest. The study provides valuable insights into the clinical features and... more

The potential impact of educational attainment on NAFLD risk. Author's reply

14 December 2024
Author(s): Florian Koutny, Elmar Aigner, Bernhard Wernly

We thank Ke-qian Chen et al. and the European Journal of Internal Medicine for the opportunity to engage in a constructive discussion about the relationship between educational attainment and non-... more

Revisiting the association between air pollution and peripheral artery disease: Evidence from mendelian randomization analysis

14 December 2024
Author(s): Zhen Deng, Lincheng Duan, Kai Wang

We read with great interest the article by Di Blasi et al., published in the European Journal of Internal Medicine [1]. This well-designed study provides significant evidence on the association... more

Hypertension – a global problem requiring a comprehensive approach

12 December 2024
Author(s): Agnieszka Zalewska, Anna Litwińska-Kmiecik, Alicja Wiśniewska

We read with great interest a recently published study by Rikuta Hamaya, Molin Wang, Ellen Hertzmark, et al. regarding modifiable lifestyle factors in the primordial prevention of hypertension [1].... more

Risk for hospital-treated infections in dermatitis herpetiformis and coeliac disease

12 December 2024
Author(s): Camilla Pasternack, Matti Karppelin, Kaisa Hervonen, Katri Kaukinen, Teea Salmi, Celiac Disease Study Group

Dear Editor,

Risk of injurious falls in older people with atrial fibrillation

10 December 2024
Author(s): Anna Litwińska-Kmiecik, Agnieszka Zalewska

Dear editor,

Use of betablockers in post-myocardial infarction patients in a real-world setting

9 December 2024
Author(s): Marta Baviera, Anna Zanovello, Luisa Ojeda-Fernández, Mauro Molteni, Claudio Cimminiello

For many years, the main guidelines have been recommending the use of betablocker therapy in patients after myocardial infarction (MI) [1,2]. This recommendation entails a high class and grade for... more

Prognostic impact of different triggers in patients with Takotsubo syndrome and chronic obstructive pulmonary disease. Author's reply

9 December 2024
Author(s): Luca Arcari, Giacomo Tini, Beatrice Musumeci, Emanuele Barbato, Luca Cacciotti

We thank the authors for the interest in our study recently published in the journal [1]. In that, we focused specifically on patients with takotsubo syndrome (TTS) and chronic obstructive pulmonary... more

High-risk allogeneic stem cells transplantation in advanced age patients with uncontrolled sickle cell disease

8 December 2024
Author(s): Frederic Garban, Caroline Makowski, Claude Eric Bulabois, Laurence Bouillet, Mathieu Meunier

Sickle cell disease (SCD) is a recessive monogenic disease where a single nucleotide mutation of the HBB gene, encoding the β-globin chain of hemoglobin (Hb), leads to the synthesis of HbS.... more

Measuring the risk of clinical adverse events (RISK ACE) by quantifying liver function: A patient-centric model

4 December 2024
Author(s): John Kittelson, Michael P. McRae, Gregory T. Everson

Identifying the patients with compensated advanced chronic liver disease (cACLD) who are at risk for clinical decompensation is a goal of clinical management [1]. Early detection of those at risk for... more

Clarifications and enhancements for cardiovascular risk study in metabolic dysfunction-associated steatotic liver disease

3 December 2024
Author(s): Yinfang Wu, Weixing Xu

This study by Shibata et al. [1] investigated the risk of major adverse cardiac events (MACE) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and employed a... more

Extra-articular manifestations in rheumatoid arthritis: Incidence and predisposing factors

2 December 2024
Author(s): Jiaxu Wang, Jigong Wu, Liqi Li

The research by Lotta Ljung et al. [1] offers valuable insights into extra-articular manifestations (ExRA) in rheumatoid arthritis (RA) yet has room for improvement. The questionnaire-based approach... more

Seasonality of diabetic ketoacidosis in hot climate

28 November 2024
Author(s): Fahmi Abu Ghalion, Mai Ofri, Victor Novack, Lena Novack

Diabetic ketoacidosis (DKA) is a life-threatening condition arising from an absolute or relative insulin deficiency, leading to hyperglycemia and ketone body accumulation in the blood with metabolic... more

Prognostic impact of different triggers in patients with Takotsubo syndrome and chronic obstructive pulmonary disease

28 November 2024
Author(s): Anna Litwińska-Kmiecik, Agnieszka Zalewska, Alicja Wiśniewska

We read with great interest a recently published study by Luca Arcari, Giacomo Tini, Michela Zuccanti, et al. regarding clinical characteristics and outcomes of Takotsubo syndrome (TTS) in patients... more

Diagnostic yield of head-up tilt testing in suspected vasovagal syncope

28 November 2024
Author(s): Pietro Guida, Federica Troisi, Antonio Di Monaco, Massimo Iacoviello, Massimo Grimaldi

Vasovagal syncope (VVS) is the most frequent form of syncopal spells characterized by a reflex causing hypotension and often bradycardia, usually elicited by prolonged standing or exposure to... more

Validating ChatGPT's role in systematic reviews and meta-analyses: A case study on GLP-1 receptor agonists and all-cause mortality

28 November 2024
Author(s): Lefteris Teperikidis, Paschalis Karakasis, Dimitrios Patoulias, Aristi Boulmpou, Dimitrios Kouzoukas, AIMES – AI for Meta-Analysis and Evidence Synthesis

Dear Editor,

Enhancing cardiovascular risk management in rheumatoid arthritis: From medication adherence to multidisciplinary interventions

26 November 2024
Author(s): Shulin Dou, Wei Fang, Wei Wang, Hailiang Wang

We carefully read the article by Cacciapaglia et al. published in the European Journal of Internal Medicine [1]. This study reveals the suboptimal adherence to lipid-lowering therapy prescriptions in... more

Enhancing hypertension prevention research: Insights and opportunities for social work interventions

25 November 2024
Author(s): Ruyi Zhou, Senlin Ye, Jinli Liu, Lincheng Duan

We read with great interest the recent article by Hamaya et al. published in the European Journal of Internal Medicine [1]. The Authors conducted a comprehensive analysis of the impact of lifestyle... more

GLP-1 receptor agonists for the treatment of obstructive sleep apnea and obesity

15 November 2024
Author(s): Livia Romariz, Beatriz Araújo, Lucas M. Barbosa, Riddhi Jain, Carolina C. Porto Silva Janovsky, Obesity Study Group

Obstructive sleep apnea (OSA) syndrome is a common disorder of repeated upper airway collapse during sleep, leading to recurrent hypoxia and hypercapnia [1]. Continuous positive airway pressure (CPAP... more

Switching from hospital centered to community based, person centered and integrated social health and care systems; Mission impossible or key objective?

14 November 2024
Author(s): Lavinia Gentile, Giuseppe Liotta, Edoardo Carnevale, Stefano Orlando, Leonardo Palombi

Length of Stay (LOS) is a widely recorded metric used in hospital management and considered an important indicator of healthcare efficiency [1]. Despite its strategic value and one of the longest... more

Vaccination trends and recent therapeutics to encounter resurgence of monkeypox

12 November 2024
Author(s): Nawal Fatima, Muhammad Ahmad, Ishtiaq Ahmed, Mohammed Hussen Bule

The World Health Organization (WHO) declared a public health emergency of international concern (PHEIC) on the resurgence of monkeypox after the 2022–2023 epidemic, a zoonotic ailment with primary... more

The potential impact of educational attainment on NAFLD risk

11 November 2024
Author(s): Ke-qian Chen, Shu-zhi Wang, Zong-bao Wang, Hai-bo Lei, Xiang Liu

We read with great interest the article by Florian Koutny and his colleagues, recently published in the European Journal of Internal Medicine [1]. In this article, Florian Koutny and his colleagues... more

Refining metabolic health assessment in inflammatory bowel disease risk prediction

29 October 2024
Author(s): Yinfang Wu, Weixing Xu

Mi et al.'s investigation [1], drawing upon the United Kingdom (UK) Biobank resource, delves into the interplay between metabolic health and genetic predisposition to inflammatory bowel disease (IBD... more

Characteristics of familial Mediterranean fever after 65 years of age

29 October 2024
Author(s): François Rodrigues, Léa Savey, Marion Delplanque, Laurence Cuisset, Sophie Georgin-Lavialle

Dear Editor,

External factors affecting weight loss during intermittent fasting. Author's reply

14 October 2024
Author(s): M. Khalil, H. Abdallah, G. Garruti, A.Di Ciaula, P. Portincasa

Dear Editor,

Comparative safety and efficacy analysis of GLP-1 receptor agonists and SGLT-2 inhibitors among frail individuals with type 2 diabetes in the era of continuous population ageing

2 October 2024
Author(s): Paschalis Karakasis, Dimitrios Patoulias, Ieva Ruža, Alberto Maria Marra, Ricardo Gómez-Huelgas

Dear Editor,

Co-management hospitalist services for neurosurgery. Where are we?

27 September 2024
Author(s): Ombretta Para, Joel Byju Valuparampil, Alberto Parenti, Carlo Nozzoli, Alessandro Della Puppa

Dear Editor, the increase in the average age of the population and in the prevalence of chronic comorbidities has made healthcare extremely difficult and sometimes with difficult home management [1,2... more

Clinical significance of the anti-Nucleolar Organizer Region 90 antibodies (NOR90) in systemic sclerosis

26 September 2024
Author(s): Wanyi Lin, Chenhan Jia, Hanlin Yin, Liangjing Lu

We read with great interest the article by Dima et al. on the clinical significance of the anti-Nucleolar Organizer Region antibodies (NOR90) in systemic sclerosis (SSc) [1]. The authors conducted a... more

Factors associated to multiple chronic conditions in internal medicine patients

20 September 2024
Author(s): Marco Vincenzo Lenti, Carmine Frenna, Alice Silvia Brera, Catherine Klersy, Gino Roberto Corazza, SMAC Study group

Dealing with patients with multiple chronic conditions (MCC) is certainly one of the most compelling healthcare challenges [1]. Most of the available data about MCC derive from large administrative... more

The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive. Author's reply

18 September 2024
Author(s): S.S.A. Simon, A.M.C. van Vliet, L. Vogt, G. Lindner, R.H.G. Olde Engberink

We thank Jaguszewski et al. [1] for their interest in our article [2] and their thoughtful comments.

FIB-4 score association with operative outcomes, truth or fibs?

12 September 2024
Author(s): Brandon Stretton, Joshua Kovoor, Edmund Tse, Guy Maddern, Stephen Bacchi, Study group investigators

In recent years, liver disease has become established as a significant predictor of poor perioperative outcomes [1]. Despite declining rates of hepatitis B and hepatitis C-related morbidity and... more

External factors affecting weight loss during intermittent fasting

11 September 2024
Author(s): Anna Litwińska-Kmiecik, Kamil Mrówczyński

we read with great interest a recently published study by Mohamad Khalil, Hala Abdallah, et al. regarding distinct biophysiological effects of Ramadan fasting and traditional intermittent fasting on... more

Diagnostic value of pleural calprotectin in differentiating complex parapneumonic effusions

6 September 2024
Author(s): Ourania S. Kotsiou, Nikolaos D. Karakousis, Dimitrios Papagiannnis, Garyfallia Perlepe, Konstantinos I. Gourgoulianis

Dear Editor,

Oh no, all we needed was monkeypox!

3 September 2024
Author(s): Giuseppe Lippi

Four years after the spread of the coronavirus disease 2019 (COVID-19) pandemic, with a worldwide epidemiology largely under control thanks to widespread immunity against severe acute respiratory... more

A bibliometric analysis of awake prone positioning for non-intubated patients

2 September 2024
Author(s): Hong Li, Yun Peng, Xixi Wan, Jiming Cai

The global coronavirus disease 2019 (COVID-19) pandemic led to severe medical, economic, and social challenges, including a critical shortage of mechanical ventilators and intensive care unit beds [1... more

Enhancing immunization strategies in heart failure: A call to action

29 August 2024
Author(s): José Guilherme Assis

Heart failure (HF) is a severe cardiovascular pathology with escalating prevalence and notable morbidity and mortality on a global scale. Addressing this condition presents an imperative, in order to... more

DNA methylation levels of the ACE2 promoter are not associated with symptoms-severity and related-disability in previously hospitalized COVID-19 survivors

24 August 2024
Author(s): César Fernández-de-las-Peñas, Gema Díaz-Gil, Antonio Gil-Crujera, Stella M. Gómez-Sánchez, Silvia Ambite-Quesada

The presence of long-lasting symptoms after suffering an acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has recently extensive attention in the last years. One of the first meta-... more

Compassion in medicine: Are we failing our future doctors?

21 August 2024
Author(s): Daniela Martins-Mendes

Dear editor,

Empagliflozin controls cirrhotic refractory ascites along with improvement of natriuresis and circulatory, cardiac, and renal function: A pilot study

20 August 2024
Author(s): Georgios Kalambokis, Ilias Tsiakas, Sebastien Filippas-Ntekouan, Maria Christaki, Haralampos Milionis

Ascites is the most common decompensating event in cirrhosis [1]. Its pathophysiology involves splanchnic arterial vasodilation and reduced effective arterial blood volume, which activate potent... more

Combining L-arginine and vitamin C improves physical frailty in hypertensive elders

20 August 2024
Author(s): Pasquale Mone, Valentina Trimarco, Maria Morgante, Bruno Trimarco, Gaetano Santulli

Hypertension is one of the most common comorbidities which has been suggested to play a pivotal role in the transition to pre-frailty and physical frailty (hereafter called frailty), especially in... more

The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive

15 August 2024
Author(s): Milosz J. Jaguszewski, Michal Pruc, Lukasz Szarpak

We read with great interest the article by Simon et al. entitled "Prediction of plasma sodium changes in the acutely ill patients: the potential role of tissue sodium content"[1]. The study focuses... more

Immune heterogeneity associated with disease severity and activity in eosinophilic granulomatosis with polyangiitis patients

10 August 2024
Author(s): Lijuan Hua, Mengyao Guo, Wenxue Bai, Dongyuan Wang, Min Xie

Dear Editor,

Atrial fibrillation-related mortality trends among adults with comorbid chronic obstructive pulmonary disease in the United States from 1999 to 2020

6 August 2024
Author(s): Usama Qamar, Waleed Qamar, Siddharth Agarwal

Atrial fibrillation-related mortality in adults with comorbid chronic obstructive pulmonary disease in the United States from 1999 to 2020.

Effect of tirzepatide on leptin and adiponectin levels

31 July 2024
Author(s): Luis E. Simental-Mendía, Mario Simental-Mendía, Laura Jazel Barragán-Zúñiga, Litzy Navarro-Tinoco

In the field of innovative treatments for type 2 diabetes, tirzepatide emerges as a novel dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide... more

Clinical trial landscape for immune thrombocytopenia: Progress and the long road ahead

31 July 2024
Author(s): Hui Li, Qin Guo, Shufen Zhou, Chengshan Guo

Immune thrombocytopenia (ITP) has seen the development and evaluation of several breakthroughs in recent clinical trials [1-4]. The clinical trial landscape for ITP provides valuable insights into... more

Integrated care and lean management in internal medicine: An ideal mix for a functioning health system?

24 July 2024
Author(s): Livio Garattini, Marco Badinella Martini, Antonino Mazzone

Many European health systems are still under pressure in the post pandemic period, mainly because of the long-term trend of ageing people requiring more and more health care. Therefore, a rational... more

Precision medicine in COPD: A possible contribution of vitamin D?

22 July 2024
Author(s): Gianluca Azzellino, Lia Ginaldi, Massimo De Martinis

we read the interesting review by Gilda Varricchi and Remo Poto on the most innovative and recent therapeutic approaches for COPD [1].

Sudden death in congenitally corrected transposition of the great vessels

19 July 2024
Author(s): Antonis A. Manolis, Theodora A. Manolis, Antonis S. Manolis

Transposition of the great arteries (TGA) comprises dextro-TGA and levo-TGA (L-TGA). In dextro-TGA, the aorta, arising from the right ventricle (RV), is positioned to the right of the pulmonary... more

Impact of an active case-finding strategy in autoimmune gastritis

16 July 2024
Author(s): Marco Vincenzo Lenti, Emanuela Miceli, Shamim Joudaki, Antonella Gentile, Antonio Di Sabatino, Autoimmune Gastritis Team

Dear Editor,

Sodium–Glucose Co-transporter 2 Inhibitors treatment improve pancreatic β-cells function and insulin resistance in patients with Type 2 diabetes

12 July 2024
Author(s): Fang-Hong Shi, Li Xu, Long Shen, Min-Jia Cao, Hao Li

Diabetes is a leading cause of death and disability [1]. Approximately, more than 1.31 billion people will have diabetes by 2050 [1,2]. Insulin resistance in target tissues and insufficient insulin... more

Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors combination therapy versus monotherapy and major adverse cardiovascular events: Do the benefits add up?

8 July 2024
Author(s): Paschalis Karakasis, Dimitrios Patoulias, Nikolaos Fragakis, María Rosa Bernal-López, Ricardo Gómez-Huelgas

Dear Editor,

Original Article

What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? – A systematic review

15 January 2025
Author(s): Joana Teixeira, Inês Pereira, Miguel Castanho, Frederico Simões do Couto

Cognitive impairments, frequently observed in Alcohol Use Disorder (AUD) patients, range from severe memory impairment with other cognitive functions relatively preserved seen in Korsakoff's Syndrome... more

Effects of population-based screening for atrial fibrillation on quality of life

12 January 2025
Author(s): Emilie Katrine Kongebro, Christian Kronborg, Lucas Yixi Xing, Ketil Jørgen Haugan, Claus Graff, Søren Højberg, Morten S Olesen, Derk Krieger, Axel Brandes, Lars Køber, Jesper Hastrup Svendsen, Søren Zöga Diederichsen

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with an increased risk of stroke, heart failure, and mortality [1]. Many cases of AF remain undetected due to no or... more

The impact of hypoalbuminemia on the long-term prognosis of patients with acute heart failure: The modifying role of carbohydrate antigen 125

3 January 2025
Author(s): Pau Llàcer, François Croset, Rafael de la Espriella, Marina García, Gema Miñana, Jorge Campos, Enrique Santas, Carlos Pérez, Miguel Lorenzo, Alberto Pérez, Gonzalo Núñez, Esteban Pérez, Luis Manzano, Julio Núñez

The main novelty of the present study is:

Adverse effects of late sleep on physical health in a large cohort of community-dwelling adults

31 December 2024
Author(s): Renske Lok, Lara Weed, Joseph Winer, Jamie M. Zeitzer

Human health is influenced by a myriad of factors, including genetics, environment, and behavior. One behavior that has received significant recent attention is the impact of sleep on human health.... more

Prevalence and impact of multidrug resistance in a cohort of patients admitted to emergency department for urinary tract-infections: The UTILY study, a prospective multicentre study

30 December 2024
Author(s): Lorenzo Onorato, Enrico Allegorico, Margherita Macera, Caterina Monari, Biagio Migliaccio, Carmine Nasta, Maria Teresa Florio, Roberta Sciorio, Fabio Giuliano Numis, Giovanna Guiotto, Mauro Giordano, Rosa Raucci, Ferdinando Dello Vicario, Rodolfo Nasti, Antonio Voza, Nicola Coppola, for UTILY study group

Urinary tract infections (UTIs) are among the most frequent bacterial infections both in community and healthcare settings [1]. The Global Burden of Diseases (GBD) has estimated an incidence of 0.4... more

The effect of a new thinking guidance of OPACCUS for shock on the 30-day mortality: A multicenter, prospective, observational, cohort study

26 December 2024
Author(s): Yi Li, Tongjuan Zou, Xueying Zeng, Yao Qin, Ran Zhou, Lianghai Cao, Jian Hu, Xianying Lei, Qionglan Dong, Yiwei Qin, Ge Zhang, Yan Kang, Bo Wang, Zhongwei Zhang, Xiaoting Wang, Yangong Chao, Wanhong Yin, Critical Care Ultrasound Study Group (CCUSG); Committee on Critical Care Ultrasound and Hemodynamics (CCUSH, SCIMEA)

Shock is the final common pathway before death and a constant focus of ICU physicians due to its high morbidity and mortality [1] (ranging from 27 % to 60 %) in critically ill patients. Recent... more

Effects of valsartan vs amlodipine and achieved lower blood pressure on the incidence of end-stage kidney disease: The VALUE Trial

18 December 2024
Author(s): Eirik Olsen, Kenneth Jamerson, Roland E. Schmieder, Camilla L. Søraas, Julian E. Mariampillai, Giuseppe Mancia, Sverre E. Kjeldsen, Sondre Heimark, Maria H. Mehlum, Knut Liestøl, Anne C.K. Larstorp, Lene V. Halvorsen, Aud Høieggen, Michel Burnier, Morten Rostrup, Stevo Julius, Michael A. Weber

There is a strong relationship between high blood pressure (BP) and the risk of developing chronic kidney disease (CKD) [1–8]. In people with CKD, a high BP is associated with a faster decline of... more

Length of hospital stay, delayed pneumonia diagnosis and post-discharge mortality. The Pneumonia in Italian Acute Care for Elderly units (PIACE)-SIGOT study

18 December 2024
Author(s): Filippo Luca Fimognari, Paolo Fabbietti, Francesco Baffa Bellucci, Andrea Corsonello, Roberto Ricchio, Massimo Rizzo, Olga Cuccurullo, Alberto Ferrari, Lorenzo Palleschi, PIACE-SIGOT Investigators

The ageing of populations in high-income countries has increased the number of vulnerable older persons requesting medical care, including care for acute and complex illnesses that warrant medical... more

Effect of continuous positive airway pressure on non-fatal stroke and paroxysmal atrial fibrillation recurrence in obstructive sleep apnoea elderly patients

16 December 2024
Author(s): Valentino Condoleo, Giandomenico Severini, Giuseppe Armentaro, Mattea Francica, Giulia Crudo, Mario De Marco, Francesco Maruca, Guglielmo Ciaccio, Carlo Fuoco, Carlo Alberto Pastura, Marcello Divino, Corrado Pelaia, Egidio Imbalzano, Mario Bo, Andrea Ungar, Angela Sciacqua

Obstructive sleep apnoea (OSA) is a respiratory disorder characterised by repeated events of upper airway collapse leading to airflow limitation [1]. OSA is often under-recognised, and if untreated,... more

Exploring phenotypes to improve long-term mortality risk stratification in obstructive sleep apnea through a machine learning approach: an observational cohort study

16 December 2024
Author(s): Pasquale Tondo, Giulia Scioscia, Sebastien Bailly, Roberto Sabato, Terence Campanino, Piera Soccio, Maria Pia Foschino Barbaro, Crescenzio Gallo, Jean-Louis Pépin, Donato Lacedonia

Obstructive sleep apnea (OSA) is a highly prevalent [1] and heterogeneous sleep disorder [2], characterized by frequent collapses of the upper airway that induce intermittent hypoxia and sleep... more

Evaluations of metabolic and innate immunity profiles in subjects with familial hypercholesterolemia with or without subclinical atherosclerosis

13 December 2024
Author(s): Giosiana Bosco, Francesco Di Giacomo Barbagallo, Maurizio Di Marco, Sabrina Scilletta, Nicoletta Miano, Stefania Capuccio, Marco Musmeci, Stefania Di Mauro, Agnese Filippello, Alessandra Scamporrino, Antonino Di Pino, Luis Masana, Francesco Purrello, Salvatore Piro, Roberto Scicali

Atherosclerosis is a chronic and progressive process promoted by several environmental and genetic factors [1,2]; among these, low-density lipoprotein cholesterol (LDL-C) has been recognized to have... more

Long-term follow-up of hereditary hemorrhagic telangiectasia patients without significant pulmonary right-to-left shunt at screening

11 December 2024
Author(s): Bernat Villanueva, Miguel Ángel Sánchez-Corral, Esther Alba, Queralt Ordi, Yolanda Ruiz, Raquel Torres-Iglesias, Alejandro Portillo, Adriana Iriarte, Cristina Monforte, Enric Gamundí, Xavier Pintó, Jesús Ribas, Antoni Riera-Mestre

Hereditary hemorrhagic telangiectasia (HHT) is a vascular genetic rare disease (ORPHA: 774) characterized by systemic telangiectases and larger vascular malformations [1]. HHT can be diagnosed using... more

Different impact of chronic kidney disease in older patients with heart failure according to frailty

7 December 2024
Author(s): Pablo Díez-Villanueva, César Jiménez-Méndez, Ángel Pérez-Rivera, Eduardo Barge Caballero, Javier López, Carolina Ortiz, Clara Bonanad, Josebe Goirigolzarri, Alberto Esteban Fernández, Marta Cobo, Nuria Montes, Albert Ariza-Solé, Manuel Martínez-Sellés, Fernando Alfonso

Chronic kidney disease (CKD) affects up to 10 % of the general population, being one-third of these individuals over 65 years old [1]. A bidirectional interaction, has been described between CKD and... more

Association between long-term exposure to air pollution and incidence of peripheral artery disease: Evidence from a longitudinal study

5 December 2024
Author(s): Chiara Di Blasi, Federica Nobile, Alberto Maria Settembrini, Massimo Stafoggia, Marina Davoli, Paola Michelozzi, Matteo Renzi, Pier Mannuccio Mannucci

Cardiovascular disease (CVD) is one the most frequent cause of death and disability globally, including Europe. CVD causes 3.9 million annual deaths in the European Union and the loss of 26 million... more

Comorbidity patterns and the risk of injurious falls in older people with atrial fibrillation: Findings from a Swedish nation-wide population-based study

30 November 2024
Author(s): Caterina Trevisan, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Jonas W. Wastesson, Kristina Johnell, Cheïma Amrouch, Graziano Onder, Alessandra Marengoni, Riccardo Proietti, Gregory Y H Lip, Søren P Johnsen, Mirko Petrovic, Davide Liborio Vetrano, on behalf of the AFFIRMO Consortium

Atrial fibrillation (AF) is the most common arrhythmia in the general population, increasing by 30 % over the last 20 years primarily as a result of the better diagnostics and ageing population [1],... more

Clinical characteristics and outcomes of Takotsubo syndrome in patients with chronic obstructive pulmonary disease

7 November 2024
Author(s): Luca Arcari, Giacomo Tini, Michela Zuccanti, Giovanni Camastra, Alessandro Cianca, Emanuela Belmonte, Giulio Montefusco, Riccardo Scirpa, Claudia Malerba, Fabrizio Lupparelli, Matteo Sclafani, Viviana Maestrini, Beatrice Musumeci, Emanuele Barbato, Luca Cacciotti

Takotsubo syndrome (TTS) is an acute heart failure syndrome characterized by a transient impairment of systolic function [1]. Adverse outcomes have been described both in the acute phase and, despite... more

Modifiable lifestyle factors in the primordial prevention of hypertension in three US cohorts

6 November 2024
Author(s): Rikuta Hamaya, Molin Wang, Ellen Hertzmark, Nancy R Cook, JoAnn E Manson, Qi Sun, Meir J Stampfer, Kenneth J. Mukamal, Gary Curhan, Eric B Rimm

Hypertension is a leading cause of cardiovascular diseases (CVD). The prevalence has doubled from 1990 to 2019 [1] and now impacts almost half of the US adult population [2], and the condition... more

Adherence to the 2019 ESC/EAS guidelines for dyslipidaemia management in a large rheumatoid arthritis cohort: Data from the CORDIS Study Group of the Italian Society of Rheumatology

5 November 2024
Author(s): Fabio Cacciapaglia, Francesca Romana Spinelli, Gian Luca Erre, Matteo Piga, Garifallia Sakellariou, Andreina Manfredi, Marco Fornaro, Ombretta Viapiana, Simone Perniola, Elisa Gremese, Fabiola Atzeni, Elena Bartoloni

The evidence that several variables, including inflammation, autoimmunity and traditional cardiovascular (CV) risk factors, closely interact to enhance atherosclerotic risk burden in rheumatoid... more

Association of non-cardiac comorbidities and sex with long-term Re-hospitalization for heart failure

31 October 2024
Author(s): Antonio E. Pontiroli, Elena Tagliabue, Fabiana Madotto, Olivia Leoni, Barbara Antonelli, Erberto Carluccio, Francesco Bandera, Giuseppe Galati, Pierpaolo Pellicori, Lars H. Lund, Giuseppe Ambrosio

Heart failure (HF) is a complex clinical syndrome, the course of which is usually complicated by concomitant comorbidities [1–6]. However, in spite of this long-held notion, the impact of non-cardiac... more

Hyperhomocysteinemia is linked to MASLD

30 October 2024
Author(s): Carlo De Matteis, Lucilla Crudele, Ersilia Di Buduo, Salvatore Cantatore, Raffaella Maria Gadaleta, Marica Cariello, Patrizia Suppressa, Gianfranco Antonica, Elsa Berardi, Giusi Graziano, Antonio Moschetta

Arterial Hypertension

Clinically relevant bleeding according to location of metastases in cancer-associated thrombosis

28 October 2024
Author(s): Victor Garcia-Garcia, Maria Barca-Hernando, Sergio Lopez-Ruz, Carmen Rosa-Linares, Teresa Elias-Hernandez, Remedios Otero-Candelera, Henry Andrade-Ruiz, Luis Jara-Palomares

Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a frequent complication in patients with cancer [1]. It is estimated that 20–30 % of VTE cases are... more

Systolic blood pressure, a predictor of mortality and life expectancy following heart failure hospitalization, 2010–2023

21 October 2024
Author(s): Mohammed Yousufuddin, Zeliang Ma, Ebrahim Barkoudah, Muhammad Waqas Tahir, Meltiady Issa, Zhen Wang, Fatmaelzahraa Badr, Ibrahim A. Gomaa, Sara Aboelmaaty, Ahmed A. Al-Anii, Sarah L. Gerard, Ahmed D. Abdalrhim, Sumit Bhagra, Arshad Jahangir, Rehan Qayyum, Gregg C. Fonarow, Mohamad H. Yamani

Each year, over 1 million Americans are admitted to hospitals with heart failure (HF) as the primary discharge diagnosis [1]. Hospitalization for acute decompensated HF (ADHF) represents a critical... more

Association between trajectory of systolic blood pressure and outcomes in heart failure patients with preserved ejection fraction (HFpEF)

17 October 2024
Author(s): Xiao Liu, Hong Pan, Yuan Jiang, Yue Wang, Ayiguli Abudukeremu, Zhengyu Cao, Maoxiong Wu, Wanbing He, Minghai Zhang, Zhiwei Yan, Qingyuan Gao, Wengen Zhu, Haifeng Zhang, Yuling Zhang, Yangxin Chen, Jingfeng Wang

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease which accounts for 50 % of all heart failure [1–3]. Currently, treatment for HFpEF not only focuses on improving... more

TLR4 and TNF-α single nucleotide polymorphisms in patients with brucellosis: Association with infection complications

16 October 2024
Author(s): Efthymia Giannitsioti, Angelos Stefos, Georgia Damoraki, Sarah Georgiadou, Maria Pavlaki, Evangelos J. Giamarellos-Bourboulis, George Dalekos

Brucellosis is a zoonotic infectious disease caused by Brucella spp, an intracellular facultative anaerobe Gram negative bacteria transmitted to humans by domestic (cattle, goats, sheep, swine, dogs... more

External validation of a prognostic score to identify low-risk outpatients with acute deep venous thrombosis in the lower limbs

14 October 2024
Author(s): Francisco Galeano-Valle, Rubén Alonso-Beato, Sergio Moragón-Ledesma, Tatiana Pire-García, Olaya Huergo-Fernández, Lucía Ordieres-Ortega, Crhistian-Mario Oblitas, Luis Antonio Alvarez-Sala Walther, Pablo Demelo-Rodríguez

Deep vein thrombosis (DVT) and pulmonary embolism (PE) stand as the primary manifestations of venous thromboembolism (VTE) [1-3]. Nonetheless, the absence of national surveillance systems for VTE... more

Hyperchloremic metabolic acidosis potentially benefiting sodium bicarbonate therapy: A multi-center cohort study

11 October 2024
Author(s): Lingfei Tong, Shuiyan Wu, Deping Li, Yanmei Cao, Huaqing Liu

Metabolic acidosis is a type of acid-base imbalance that significantly impacts prognosis. It can be caused by poisoning, infections, surgeries, acute and chronic renal failure, diabetic ketosis, and... more

Prediction of left ventricular thrombus after myocardial infarction: a cardiac magnetic resonance-based prospective registry

8 October 2024
Author(s): Carlos Bertolin-Boronat, Víctor Marcos-Garcés, Hector Merenciano-González, Nerea Perez, Candelas Pérez del Villar, Jose Gavara, Maria P. Lopez-Lereu, Jose V. Monmeneu, Cristian Herrera Flores, Blanca Domenech-Ximenos, Francisco Jesús López-Fornás, Cesar Rios-Navarro, Elena de Dios, David Moratal, Jose T. Ortiz-Pérez, Antoni Bayes-Genis, Jose F Rodríguez-Palomares, Julio Nuñez, Pedro L. Sánchez, Juan Sanchis, Vicente Bodi

Left ventricular thrombus (LVTh) is a rare but serious complication following ST-segment elevation myocardial infarction (STEMI) [1–4]. During the prethrombolytic era, LVTh was detected in up to 60%... more

Prospective study of risk factors for community-acquired acute kidney injury

4 October 2024
Author(s): Telma H Ragnarsdotttir, Margret Kristjansdottir, Gisli Gislason, Vicente Sanchez-Brunete, Margret O Tomasdottir, Olafur H Samuelsson, Runolfur Palsson, Olafur S Indridason

Acute kidney injury (AKI) is a common condition, both in hospital and outpatient settings, and is associated with increased mortality, prolonged hospital stay, progressive chronic kidney disease (CKD... more

A large language model-based clinical decision support system for syncope recognition in the emergency department: A framework for clinical workflow integration

28 September 2024
Author(s): Alessandro Giaj Levra, Mauro Gatti, Roberto Mene, Dana Shiffer, Giorgio Costantino, Monica Solbiati, Raffaello Furlan, Franca Dipaola

Syncope is a common presenting symptom in the emergency department (ED), [1,2] the management of which poses inherent challenges, starting from recognition. Crucial information is collected during... more

Carotid plaque offsets sex-related differences in cardiovascular risk of young hypertensive patients

17 September 2024
Author(s): Costantino Mancusi, Christian Basile, Eva Gerdts, Ilaria Fucile, Maria Virginia Manzi, Maria Lembo, Daniela Pacella, Giuseppe Giugliano, Grazia Canciello, Raffaele Piccolo, Alessandra Spinelli, Carmine Morisco, Nicola De Luca, Bruno Trimarco, Giovanni de Simone, Eduardo Bossone, Raffaele Izzo, Maria Angela Losi, Giovanni Esposito

Risk for cardiovascular disease (CVD), in particular risk for coronary artery disease and acute coronary syndrome, is lifelong higher in men than in women [1], although this difference is attenuated... more

Impaired insulin sensitivity measured by estimated glucose disposal rate is associated with decreased myocardial mechano-energetic efficiency in non-diabetic individuals

16 September 2024
Author(s): Chiara M.A. Cefalo, Alessia Riccio, Teresa Vanessa Fiorentino, Elena Succurro, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti

Atherosclerotic cardiovascular diseases encompassing coronary artery disease, and stroke, remain major causes of death worldwide regardless the substantial advances in the prevention and treatment of... more

The impact of the COVID-19 Pandemic on hypertension phenotypes (ESH ABPM COVID-19 study)

10 September 2024
Author(s): Aleksandra Ostrowska, Wiktoria Wojciechowska, Marek Rajzer, Thomas Weber, Michael Bursztyn, Alexandre Persu, George Stergiou, Grzegorz Kiełbasa, Marzena Chrostowska, Michaelis Doumas, Gianfranco Parati, Grzegorz Bilo, Guido Grassi, Giuseppe Mancia, Andrzej Januszewicz, Reinhold Kreutz, ESH ABPM COVID-19 Study Investigators

The COVID-19 pandemic had a significant impact on various aspects of public health. The imposed restrictions forced people to spend more time at home, which may have resulted in a decline in physical... more

Predictors of pulmonary embolism in chronic obstructive pulmonary diseases patients admitted for worsening respiratory symptoms: An individual participant data meta-analyses

9 September 2024
Author(s): Valentine Mismetti, Francis Couturaud, Olivier Sanchez, Raquel Morillo, Edouard Ollier, Carmen Rodriguez, Pierre-Marie Roy, Pedro Ruiz-Artacho, Frédéric Gagnadoux, Raphael Le-Mao, Eva Tabernero, Michel Nonent, Jeannot Schmidt, Laurent Bertoletti, David Jimenez

Chronic obstructive pulmonary disease (COPD) is a widespread condition with significant morbidity and mortality [1,2]. It is one of the leading causes of death and is already expected to experience a... more

Thrombosis in breast cancer patients on cyclin-dependent kinase inhibitors: Survival impact and predictive factors - A study by the cancer and thrombosis group of the spanish society of medical oncology (SEOM)

20 August 2024
Author(s): Manuel Sánchez Cánovas, Javier López Robles, Evdochia Adoamnei, Diego Cacho Lavin, Carmen Diaz Pedroche, Eva Coma Salvans, Teresa Quintanar Verduguez, Francisco José García Verdejo, Mónica Cejuela Solís, Silvia García Adrián, Berta Obispo Portero, Alberto Garrido Fernández, Carmen Salvador Coloma, María Purificación Martínez del Prado, Jaime Mendiola, Andres J. Muñoz Martín

TESEO registry data indicate that breast cancer ranks third in cases of cancer-associated thrombosis [1]. This cannot be solely attributed to the prevalence of malignant breast pathology, as a study... more

Towards a comprehensive approach to the management and prognosis of systemic sclerosis's patients: The role of comorbidities in the SPRING-SIR registry

14 August 2024
Author(s): Martina Orlandi, Silvia Bellando-Randone, Rossella De Angelis, Clodoveo Ferri, Dilia Giuggioli, Fabio Cacciapaglia, Luca Magnani, Giovanna Cuomo, Antonietta Gigante, Veronica Codullo, Corrado Campochiaro, Alarico Ariani, Rosario Foti, Serena Guiducci, Marco Matucci-Cerinic, Cosimo Bruni, SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society of Rheumatology) coworkers

In systemic sclerosis (SSc), widespread skin and visceral fibrosis are associated with poor outcome and increased mortality [1]. For this reason, SSc management remains a challenge due to clinical... more

Treatment of systemic lupus erythematosus: Analysis of treatment patterns in adult and paediatric patients across four European countries

11 August 2024
Author(s): Mike Du, Francesco Dernie, Martí Català, Antonella Delmestri, Wai Yi Man, James T. Brash, Hanne van Ballegooijen, Núria Mercadé-Besora, Talita Duarte-Salles, Miguel-Angel Mayer, Angela Leis, Juan Manuel Ramírez-Anguita, Romain Griffier, Guillaume Verdy, Albert Prats-Uribe, Alexandra Pacurariu, Daniel R. Morales, Roberto De Lisa, Sara Galluzzo, Gunter F. Egger, Daniel Prieto-Alhambra, Eng Hooi Tan

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder of connective tissue with a highly variable clinical presentation, disease course and prognosis [1]. SLE is characterised by... more

Prevalence and clinical determinants of rapid eGFR decline among patients with newly diagnosed type 2 diabetes

10 August 2024
Author(s): Giuseppina Tiziana Russo, Annalisa Giandalia, Giuseppe Lucisano, Maria Chiara Rossi, Pamela Piscitelli, Roberto Pontremoli, Francesca Viazzi, Alberto Rocca, Valeria Manicardi, Graziano Di Cianni, Riccardo Candido, Antonio Nicolucci, Salvatore De Cosmo, AMD Annals Study Group

Diabetic kidney disease (DKD) is the most common cause of end-stage kidney disease (ESKD) in the western world, accounting for more than 40 % of patients that require kidney replacement therapy [1].... more

Prevalence and clinical predictors of vasodepressor syncope during head up tilt test

7 August 2024
Author(s): Vincenzo Russo, Moiz Tariq, Erika Parente, Angelo Comune, Anna Rago, Andrea Antonio Papa, Gerardo Nigro, Michele Brignole

Head-up tilt test (HUTT) is a useful diagnostic tool for patients with suspected reflex syncope after initial clinical assessment [1]. When using the Italian protocol, HUTT allows to confirm the... more

Prognostic role of gait speed in worsening heart failure

7 August 2024
Author(s): Camilla Cirelli, Raul Limonta, Greta Carioli, Emilia D'Elia, Pietro Ameri, Riccardo Maria Inciardi, Arianna Ghirardi, Luca Fazzini, Ferdinando Perra, Ginevra Rizzola, Erika Chiesa, Laura Tomasoni, Roberta Montisci, Antonello Gavazzi, Michele Senni, Mauro Gori

Heart failure (HF) is a progressive disease, affecting more than 60 million people worldwide [1]. Despite advances in treatment options, HF is associated with a high risk of mortality and morbidity.... more

Functional limitation predicts mortality in heart failure with preserved ejection fraction

31 July 2024
Author(s): Domenico Scrutinio, Pietro Guida, Andrea Passantino

Globally, more than 64 million people are affected by HF [1]. The estimated prevalence of HF is 1 % to 3 % in Europe and 2.1 % in the USA [2,3]. The estimated incidence is 1 to 4 cases per 1000... more

Distribution and prognostic impact of different heart failure etiologies in patients with heart failure with mildly reduced ejection fraction

18 July 2024
Author(s): Tobias Schupp, Alexander Schmitt, Felix Lau, Marielen Reinhardt, Noah Abel, Mohammad Abumayyaleh, Mohamed Ayoub, Kambis Mashayekhi, Muharrem Akin, Jonas Rusnak, Kathrin Weidner, Ibrahim Akin, Michael Behnes

As a result of ongoing demographic changes and an ageing population, the overall number of patients with heart failure (HF) has significantly increased. It is estimated that more than 60 million... more

Practice Guidelines

Treatment of hospitalized patient with hyperglycemia: An EFIM critically appraised and adapted guideline

9 December 2024
Author(s): Oğuz Abdullah Uyaroğlu, Ieva Ruza, Jan Skrha, Dimitrios Patoulias, Sebastjan Bevc, Biljana Ivanovska Bojadjiev, Ricardo Gómez-Huelgas, Jörg Bojunga, Wiktoria Lesniak, Juana Carretero-Gómez, Julio Wacker, Luis M. Pérez-Belmonte, Dror Dicker, Tadej Petreski, Ignacio Marín-León

Over the past decade, diabetes mellitus (DM) has emerged as a growing epidemic with an estimated global prevalence of 10.5 % (537 million people) in 2021, according to the International Diabetes... more

Review Article

Chronic obstructive pulmonary disease: A narrative synthesis of its hallmarks for palliative care clinicians

9 January 2025
Author(s): Jacopo D'Andria Ursoleo, Alice Bottussi, Donald R. Sullivan, Corrado D'Andria, Natalia Smirnova, William E. Rosa, Stefano Nava, Fabrizio Monaco

Chronic obstructive pulmonary disease (COPD) accounts for approximately 55 % of cases of respiratory diseases and is now the third cause of both death and morbidity worldwide [1]. Its prevalence is... more

Practical management of severe acute pancreatitis

29 November 2024
Author(s): Karim Hamesch, Marcus Hollenbach, Lucía Guilabert, Tobias Lahmer, Alexander Koch

Diagnosis of acute pancreatitis (AP) is based on the Revised Atlanta Classification[1] (Table 1) requiring at least two of three criteria: i) typical epigastric pain radiating to the back, ii) serum... more

Transforming organ donation and transplantation: Strategies for increasing donor participation and system efficiency

20 November 2024
Author(s): David B. Olawade, Sheila Marinze, Nabeel Qureshi, Kusal Weerasinghe, Jennifer Teke

Organ transplantation stands as one of the most significant advancements in modern medicine, providing life-saving solutions for patients with end-stage organ failure [1]. From the first successful... more

Translating evidence into practice: Managing electrolyte imbalances and iron deficiency in heart failure

9 November 2024
Author(s): Ryosuke Sato, Michael J. Koziolek, Stephan von Haehling

Heart failure (HF) is defined as a clinical syndrome with symptoms and/or signs caused by a structural and/or functional cardiac abnormality, corroborated by elevated natriuretic peptides and/or... more

New strategies for the treatment of hyperkalemia

2 November 2024
Author(s): Stefano Masi, Herman Dalpiaz, Sara Piludu, Federica Piani, Giulia Fiorini, Claudio Borghi

Potassium (K+) is the most abundant cation in the body (50–75 mEq/L/kg body weight). Under physiological conditions, approximately 98 % of total body K+ is located in the intracellular space and only... more

Triglyceride glucose (TyG) index: A promising biomarker for diagnosis and treatment of different diseases

28 October 2024
Author(s): Yuting Sun, Hangyu Ji, Wenjie Sun, Xuedong An, Fengmei Lian

Insulin resistance (IR) is a metabolic condition in which insulin levels are elevated due to insensitivity to insulin and associated with elevated triglyceride levels. Hypertriglyceridemia leads to... more

Chronic obstructive pulmonary disease's eosinophilic phenotype: Clinical characteristics, biomarkers and biotherapy

22 October 2024
Author(s): Mauro Maniscalco, Claudio Candia, Pasquale Ambrosino, Antonio Iovine, Salvatore Fuschillo

COPD is a complex, heterogeneous, and chronic inflammatory disorder of the airways characterized by persistent and poorly reversible airflow limitation, along with significant respiratory symptoms... more

Gliflozines use in heart failure patients. Focus on renal actions and overview of clinical experience

21 September 2024
Author(s): Edoardo Gronda, Massimo Iacoviello, Arduino Arduini, Manuela Benvenuto, Domenico Gabrielli, Mario Bonomini, Luigi Tavazzi

In the past decades impressive progress in heart failure (HF) treatment has been achieved by adoption of therapeutic tools ranging from renin angiotensin system antagonists to beta blocking agents,... more

Diet and physical exercise in elderly people with obesity: The state of the art

18 August 2024
Author(s): Francesca Battista, Silvia Bettini, Ludovica Verde, Luca Busetto, Luigi Barrea, Giovanna Muscogiuri

“Obesity and ageing: two side of the same coin” in 2020 Tam et al. have summarised the complex pathophysiological interaction and mutual relationship between obesity and ageing in a comprehensive... more

Metabolic Bariatric surgery in People with Obesity aged ≥65 Years

30 March 2024
Author(s): Nursel Çalık Başaran, Dana Marcoviciu, Dror Dicker

The World Health Organization (WHO) estimated that 1.4 billion people in the world will be aged 60 years and older in 2030 and 2.1 billion by 2050, comprising 12–22 % of the global population [1].... more

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