Evidence on viral mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent causing the coronavirus disease, 2019 (COVID-19), suggests the involvement of several receptors, being the surface receptor for S1 of the angiotensin-converting enzyme 2 (ACE2) or transmembrane protease serine‑2 (TMPRSS2) receptors the most investigated [1]. The role of single nucleotid polymorpshims (SNPs) of ACE2 and TMPRSS2 genes in severe COVID-19 has received particular attention, being the ACE2 rs2285666 and TMPRSS2 rs12329760 the SNPs most commonly investigated, although with heterogeneous associations [2–4].
