Published: 28 June 2025
Author(s): Irene Mattioli, Michela Gasparotto, Alberto Bergamini, Alessandra Bortoluzzi, Francesco Ciccia, Fabrizio Conti, Maria Antonietta D'agostino, Micaela Fredi, Roberto Giacomelli, Florenzo Iannone, Ilaria Mormile, Matteo Piga, Luca Quartuccio, Gian Domenico Sebastiani, Chiara Tani, Angelo Vacca, Margherita Zen, Alessandra Bettiol, Giacomo Emmi, ESCULAPIO consortium
Issue: July 2025
Section: Original Article

Systemic Lupus Erythematosus (SLE) is a multifaceted systemic autoimmune disorder distinguished by a diverse array of clinical manifestations that can potentially impact any organ or system in the body. The disease exhibits a broad spectrum of severity and clinical trajectories, predominantly presenting as persistently active, relapsing-remitting, or frequently flaring phenotypes [1]. Understanding the complexity of SLE is essential, as it not only poses significant challenges for diagnosis and management, but also entails a considerable burden on healthcare systems worldwide.

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